Total biosynthesis of opiates by stepwise fermentation using engineered Escherichia coli

Opiates—the gold standard for pain relief—are currently produced by extraction from opium poppies. Here the authors show that bacteria can serve as an efficient and flexible platform for the production of opiates by demonstrating the total synthesis of Thebaine and hydrocodone from stepwise fermenta...

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Autores principales:	Akira Nakagawa, Eitaro Matsumura, Takashi Koyanagi, Takane Katayama, Noriaki Kawano, Kayo Yoshimatsu, Kenji Yamamoto, Hidehiko Kumagai, Fumihiko Sato, Hiromichi Minami
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b8e95cfdf252483ab4dd74f7d9237b19
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spelling	oai:doaj.org-article:b8e95cfdf252483ab4dd74f7d9237b192021-12-02T17:31:36ZTotal biosynthesis of opiates by stepwise fermentation using engineered Escherichia coli10.1038/ncomms103902041-1723https://doaj.org/article/b8e95cfdf252483ab4dd74f7d9237b192016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10390https://doaj.org/toc/2041-1723Opiates—the gold standard for pain relief—are currently produced by extraction from opium poppies. Here the authors show that bacteria can serve as an efficient and flexible platform for the production of opiates by demonstrating the total synthesis of Thebaine and hydrocodone from stepwise fermentation in E. coli.Akira NakagawaEitaro MatsumuraTakashi KoyanagiTakane KatayamaNoriaki KawanoKayo YoshimatsuKenji YamamotoHidehiko KumagaiFumihiko SatoHiromichi MinamiNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Akira Nakagawa Eitaro Matsumura Takashi Koyanagi Takane Katayama Noriaki Kawano Kayo Yoshimatsu Kenji Yamamoto Hidehiko Kumagai Fumihiko Sato Hiromichi Minami Total biosynthesis of opiates by stepwise fermentation using engineered Escherichia coli
description	Opiates—the gold standard for pain relief—are currently produced by extraction from opium poppies. Here the authors show that bacteria can serve as an efficient and flexible platform for the production of opiates by demonstrating the total synthesis of Thebaine and hydrocodone from stepwise fermentation in E. coli.
format	article
author	Akira Nakagawa Eitaro Matsumura Takashi Koyanagi Takane Katayama Noriaki Kawano Kayo Yoshimatsu Kenji Yamamoto Hidehiko Kumagai Fumihiko Sato Hiromichi Minami
author_facet	Akira Nakagawa Eitaro Matsumura Takashi Koyanagi Takane Katayama Noriaki Kawano Kayo Yoshimatsu Kenji Yamamoto Hidehiko Kumagai Fumihiko Sato Hiromichi Minami
author_sort	Akira Nakagawa
title	Total biosynthesis of opiates by stepwise fermentation using engineered Escherichia coli
title_short	Total biosynthesis of opiates by stepwise fermentation using engineered Escherichia coli
title_full	Total biosynthesis of opiates by stepwise fermentation using engineered Escherichia coli
title_fullStr	Total biosynthesis of opiates by stepwise fermentation using engineered Escherichia coli
title_full_unstemmed	Total biosynthesis of opiates by stepwise fermentation using engineered Escherichia coli
title_sort	total biosynthesis of opiates by stepwise fermentation using engineered escherichia coli
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/b8e95cfdf252483ab4dd74f7d9237b19
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Total biosynthesis of opiates by stepwise fermentation using engineered Escherichia coli

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