Dietary cholesterol-induced post-testicular infertility.

This work shows that an overload of dietary cholesterol causes complete infertility in dyslipidemic male mice (the Liver X Receptor-deficient mouse model). Infertility resulted from post-testicular defects affecting the fertilizing potential of spermatozoa. Spermatozoa of cholesterol-fed lxr-/- anim...

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Autores principales:	Aurélia Ouvrier, Georges Alves, Christelle Damon-Soubeyrand, Geoffroy Marceau, Rémi Cadet, Laurent Janny, Florence Brugnon, Ayhan Kocer, Aurélien Pommier, Jean-Marc A Lobaccaro, Joël R Drevet, Fabrice Saez
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b8eb6fbebb10451fb286bd6504bdb642
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spelling	oai:doaj.org-article:b8eb6fbebb10451fb286bd6504bdb6422021-11-18T07:35:09ZDietary cholesterol-induced post-testicular infertility.1932-620310.1371/journal.pone.0026966https://doaj.org/article/b8eb6fbebb10451fb286bd6504bdb6422011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22073227/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203This work shows that an overload of dietary cholesterol causes complete infertility in dyslipidemic male mice (the Liver X Receptor-deficient mouse model). Infertility resulted from post-testicular defects affecting the fertilizing potential of spermatozoa. Spermatozoa of cholesterol-fed lxr-/- animals were found to be dramatically less viable and motile, and highly susceptible to undergo a premature acrosome reaction. We also provide evidence, that this lipid-induced infertility is associated with the accelerated appearance of a highly regionalized epididymal phenotype in segments 1 and 2 of the caput epididymidis that was otherwise only observed in aged LXR-deficient males. The epididymal epithelial phenotype is characterized by peritubular accumulation of cholesteryl ester lipid droplets in smooth muscle cells lining the epididymal duct, leading to their transdifferentiation into foam cells that eventually migrate through the duct wall, a situation that resembles the inflammatory atherosclerotic process. These findings establish the high level of susceptibility of epididymal sperm maturation to dietary cholesterol overload and could partly explain reproductive failures encountered by young dyslipidemic men as well as ageing males wishing to reproduce.Aurélia OuvrierGeorges AlvesChristelle Damon-SoubeyrandGeoffroy MarceauRémi CadetLaurent JannyFlorence BrugnonAyhan KocerAurélien PommierJean-Marc A LobaccaroJoël R DrevetFabrice SaezPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 11, p e26966 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Aurélia Ouvrier Georges Alves Christelle Damon-Soubeyrand Geoffroy Marceau Rémi Cadet Laurent Janny Florence Brugnon Ayhan Kocer Aurélien Pommier Jean-Marc A Lobaccaro Joël R Drevet Fabrice Saez Dietary cholesterol-induced post-testicular infertility.
description	This work shows that an overload of dietary cholesterol causes complete infertility in dyslipidemic male mice (the Liver X Receptor-deficient mouse model). Infertility resulted from post-testicular defects affecting the fertilizing potential of spermatozoa. Spermatozoa of cholesterol-fed lxr-/- animals were found to be dramatically less viable and motile, and highly susceptible to undergo a premature acrosome reaction. We also provide evidence, that this lipid-induced infertility is associated with the accelerated appearance of a highly regionalized epididymal phenotype in segments 1 and 2 of the caput epididymidis that was otherwise only observed in aged LXR-deficient males. The epididymal epithelial phenotype is characterized by peritubular accumulation of cholesteryl ester lipid droplets in smooth muscle cells lining the epididymal duct, leading to their transdifferentiation into foam cells that eventually migrate through the duct wall, a situation that resembles the inflammatory atherosclerotic process. These findings establish the high level of susceptibility of epididymal sperm maturation to dietary cholesterol overload and could partly explain reproductive failures encountered by young dyslipidemic men as well as ageing males wishing to reproduce.
format	article
author	Aurélia Ouvrier Georges Alves Christelle Damon-Soubeyrand Geoffroy Marceau Rémi Cadet Laurent Janny Florence Brugnon Ayhan Kocer Aurélien Pommier Jean-Marc A Lobaccaro Joël R Drevet Fabrice Saez
author_facet	Aurélia Ouvrier Georges Alves Christelle Damon-Soubeyrand Geoffroy Marceau Rémi Cadet Laurent Janny Florence Brugnon Ayhan Kocer Aurélien Pommier Jean-Marc A Lobaccaro Joël R Drevet Fabrice Saez
author_sort	Aurélia Ouvrier
title	Dietary cholesterol-induced post-testicular infertility.
title_short	Dietary cholesterol-induced post-testicular infertility.
title_full	Dietary cholesterol-induced post-testicular infertility.
title_fullStr	Dietary cholesterol-induced post-testicular infertility.
title_full_unstemmed	Dietary cholesterol-induced post-testicular infertility.
title_sort	dietary cholesterol-induced post-testicular infertility.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/b8eb6fbebb10451fb286bd6504bdb642
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Dietary cholesterol-induced post-testicular infertility.

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