The difference in prolonged continuous and intermittent Pringle maneuver during complex hepatectomy for hepatocellular carcinoma patients with chronic liver disease: A retrospective cohort study

Abstract Purpose To explore the differences between prolonged continuous Pringle maneuver (CPM) and prolonged intermittent Pringle maneuver (IPM) in patients with hepatocellular carcinoma (HCC), who underwent complex hepatectomy. Methods This retrospective cohort study performed between June 2014 an...

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Autores principales:	Jianwei Liu, Wei Wang, Chunchao Shi, Chenqi Li, Feng Xue, Lei Hu, Yi Wang, Ruiliang Ge
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	bleeding complications continuous Pringle maneuver intermittent Pringle maneuver liver function Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/b8ec7e7a348347f89c4c42027b0250e1
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spelling	oai:doaj.org-article:b8ec7e7a348347f89c4c42027b0250e12021-12-01T04:49:15ZThe difference in prolonged continuous and intermittent Pringle maneuver during complex hepatectomy for hepatocellular carcinoma patients with chronic liver disease: A retrospective cohort study2045-763410.1002/cam4.4361https://doaj.org/article/b8ec7e7a348347f89c4c42027b0250e12021-12-01T00:00:00Zhttps://doi.org/10.1002/cam4.4361https://doaj.org/toc/2045-7634Abstract Purpose To explore the differences between prolonged continuous Pringle maneuver (CPM) and prolonged intermittent Pringle maneuver (IPM) in patients with hepatocellular carcinoma (HCC), who underwent complex hepatectomy. Methods This retrospective cohort study performed between June 2014 and May 2016 included 142 patients who underwent complex hepatectomy for HCC and concomitant chronic liver disease but with good liver function. Patients were categorized into CPM (n = 69) and IPM groups (n = 73). The differences in these aspects were compared between the two groups which include operation time, intraoperative bleeding, perioperative transfusion, postoperative complications, liver function injury, postoperative overall survival (OS), and tumor recurrence. Results The cumulative clamping time, operation time, intraoperative bleeding, and perioperative transfusion rates were 38.0, 132 min, 300 ml, and 17.4% in CPM and 40.0, 145 min, 400 ml, and 32.9% in IPM, respectively. There were significant intergroup differences in operation time (p = 0.018), intraoperative bleeding (p < 0.001), and perioperative transfusion rates (p = 0.034). Besides, the postoperative complications and postoperative liver function injury of the CPM group were better than those of IPM. There was no significant intergroup difference in OS (p = 0.908) and tumor recurrence (p = 0.671) between two groups. Conclusion Compared with IPM, CPM with a cumulative clamping time between 30 and 50 min can shorten operation time, reduce intraoperative bleeding and perioperative transfusion, and reduce postoperative complications and postoperative liver function injury in patients who underwent complex hepatectomy for HCC and concomitant liver disease but with good liver function. There was no significant difference in OS and tumor recurrence between two groups.Jianwei LiuWei WangChunchao ShiChenqi LiFeng XueLei HuYi WangRuiliang GeWileyarticlebleedingcomplicationscontinuous Pringle maneuverintermittent Pringle maneuverliver functionNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancer Medicine, Vol 10, Iss 23, Pp 8507-8517 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bleeding complications continuous Pringle maneuver intermittent Pringle maneuver liver function Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	bleeding complications continuous Pringle maneuver intermittent Pringle maneuver liver function Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Jianwei Liu Wei Wang Chunchao Shi Chenqi Li Feng Xue Lei Hu Yi Wang Ruiliang Ge The difference in prolonged continuous and intermittent Pringle maneuver during complex hepatectomy for hepatocellular carcinoma patients with chronic liver disease: A retrospective cohort study
description	Abstract Purpose To explore the differences between prolonged continuous Pringle maneuver (CPM) and prolonged intermittent Pringle maneuver (IPM) in patients with hepatocellular carcinoma (HCC), who underwent complex hepatectomy. Methods This retrospective cohort study performed between June 2014 and May 2016 included 142 patients who underwent complex hepatectomy for HCC and concomitant chronic liver disease but with good liver function. Patients were categorized into CPM (n = 69) and IPM groups (n = 73). The differences in these aspects were compared between the two groups which include operation time, intraoperative bleeding, perioperative transfusion, postoperative complications, liver function injury, postoperative overall survival (OS), and tumor recurrence. Results The cumulative clamping time, operation time, intraoperative bleeding, and perioperative transfusion rates were 38.0, 132 min, 300 ml, and 17.4% in CPM and 40.0, 145 min, 400 ml, and 32.9% in IPM, respectively. There were significant intergroup differences in operation time (p = 0.018), intraoperative bleeding (p < 0.001), and perioperative transfusion rates (p = 0.034). Besides, the postoperative complications and postoperative liver function injury of the CPM group were better than those of IPM. There was no significant intergroup difference in OS (p = 0.908) and tumor recurrence (p = 0.671) between two groups. Conclusion Compared with IPM, CPM with a cumulative clamping time between 30 and 50 min can shorten operation time, reduce intraoperative bleeding and perioperative transfusion, and reduce postoperative complications and postoperative liver function injury in patients who underwent complex hepatectomy for HCC and concomitant liver disease but with good liver function. There was no significant difference in OS and tumor recurrence between two groups.
format	article
author	Jianwei Liu Wei Wang Chunchao Shi Chenqi Li Feng Xue Lei Hu Yi Wang Ruiliang Ge
author_facet	Jianwei Liu Wei Wang Chunchao Shi Chenqi Li Feng Xue Lei Hu Yi Wang Ruiliang Ge
author_sort	Jianwei Liu
title	The difference in prolonged continuous and intermittent Pringle maneuver during complex hepatectomy for hepatocellular carcinoma patients with chronic liver disease: A retrospective cohort study
title_short	The difference in prolonged continuous and intermittent Pringle maneuver during complex hepatectomy for hepatocellular carcinoma patients with chronic liver disease: A retrospective cohort study
title_full	The difference in prolonged continuous and intermittent Pringle maneuver during complex hepatectomy for hepatocellular carcinoma patients with chronic liver disease: A retrospective cohort study
title_fullStr	The difference in prolonged continuous and intermittent Pringle maneuver during complex hepatectomy for hepatocellular carcinoma patients with chronic liver disease: A retrospective cohort study
title_full_unstemmed	The difference in prolonged continuous and intermittent Pringle maneuver during complex hepatectomy for hepatocellular carcinoma patients with chronic liver disease: A retrospective cohort study
title_sort	difference in prolonged continuous and intermittent pringle maneuver during complex hepatectomy for hepatocellular carcinoma patients with chronic liver disease: a retrospective cohort study
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/b8ec7e7a348347f89c4c42027b0250e1
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The difference in prolonged continuous and intermittent Pringle maneuver during complex hepatectomy for hepatocellular carcinoma patients with chronic liver disease: A retrospective cohort study

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