Long-term repair of porcine articular cartilage using cryopreservable, clinically compatible human embryonic stem cell-derived chondrocytes

Abstract Osteoarthritis (OA) impacts hundreds of millions of people worldwide, with those affected incurring significant physical and financial burdens. Injuries such as focal defects to the articular surface are a major contributing risk factor for the development of OA. Current cartilage repair st...

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Autores principales:	Frank A. Petrigliano, Nancy Q. Liu, Siyoung Lee, Jade Tassey, Arijita Sarkar, Yucheng Lin, Liangliang Li, Yifan Yu, Dawei Geng, Jiankang Zhang, Ruzanna Shkhyan, Jacob Bogdanov, Ben Van Handel, Gabriel B. Ferguson, Youngjoo Lee, Svenja Hinderer, Kuo-Chang Tseng, Aaron Kavanaugh, J. Gage Crump, April D. Pyle, Katja Schenke-Layland, Fabrizio Billi, Liming Wang, Jay Lieberman, Mark Hurtig, Denis Evseenko
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/b8f0ca6279f04f559470bd64f3f242af
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spelling	oai:doaj.org-article:b8f0ca6279f04f559470bd64f3f242af2021-11-28T12:38:27ZLong-term repair of porcine articular cartilage using cryopreservable, clinically compatible human embryonic stem cell-derived chondrocytes10.1038/s41536-021-00187-32057-3995https://doaj.org/article/b8f0ca6279f04f559470bd64f3f242af2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41536-021-00187-3https://doaj.org/toc/2057-3995Abstract Osteoarthritis (OA) impacts hundreds of millions of people worldwide, with those affected incurring significant physical and financial burdens. Injuries such as focal defects to the articular surface are a major contributing risk factor for the development of OA. Current cartilage repair strategies are moderately effective at reducing pain but often replace damaged tissue with biomechanically inferior fibrocartilage. Here we describe the development, transcriptomic ontogenetic characterization and quality assessment at the single cell level, as well as the scaled manufacturing of an allogeneic human pluripotent stem cell-derived articular chondrocyte formulation that exhibits long-term functional repair of porcine articular cartilage. These results define a new potential clinical paradigm for articular cartilage repair and mitigation of the associated risk of OA.Frank A. PetriglianoNancy Q. LiuSiyoung LeeJade TasseyArijita SarkarYucheng LinLiangliang LiYifan YuDawei GengJiankang ZhangRuzanna ShkhyanJacob BogdanovBen Van HandelGabriel B. FergusonYoungjoo LeeSvenja HindererKuo-Chang TsengAaron KavanaughJ. Gage CrumpApril D. PyleKatja Schenke-LaylandFabrizio BilliLiming WangJay LiebermanMark HurtigDenis EvseenkoNature PortfolioarticleMedicineRENnpj Regenerative Medicine, Vol 6, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Frank A. Petrigliano Nancy Q. Liu Siyoung Lee Jade Tassey Arijita Sarkar Yucheng Lin Liangliang Li Yifan Yu Dawei Geng Jiankang Zhang Ruzanna Shkhyan Jacob Bogdanov Ben Van Handel Gabriel B. Ferguson Youngjoo Lee Svenja Hinderer Kuo-Chang Tseng Aaron Kavanaugh J. Gage Crump April D. Pyle Katja Schenke-Layland Fabrizio Billi Liming Wang Jay Lieberman Mark Hurtig Denis Evseenko Long-term repair of porcine articular cartilage using cryopreservable, clinically compatible human embryonic stem cell-derived chondrocytes
description	Abstract Osteoarthritis (OA) impacts hundreds of millions of people worldwide, with those affected incurring significant physical and financial burdens. Injuries such as focal defects to the articular surface are a major contributing risk factor for the development of OA. Current cartilage repair strategies are moderately effective at reducing pain but often replace damaged tissue with biomechanically inferior fibrocartilage. Here we describe the development, transcriptomic ontogenetic characterization and quality assessment at the single cell level, as well as the scaled manufacturing of an allogeneic human pluripotent stem cell-derived articular chondrocyte formulation that exhibits long-term functional repair of porcine articular cartilage. These results define a new potential clinical paradigm for articular cartilage repair and mitigation of the associated risk of OA.
format	article
author	Frank A. Petrigliano Nancy Q. Liu Siyoung Lee Jade Tassey Arijita Sarkar Yucheng Lin Liangliang Li Yifan Yu Dawei Geng Jiankang Zhang Ruzanna Shkhyan Jacob Bogdanov Ben Van Handel Gabriel B. Ferguson Youngjoo Lee Svenja Hinderer Kuo-Chang Tseng Aaron Kavanaugh J. Gage Crump April D. Pyle Katja Schenke-Layland Fabrizio Billi Liming Wang Jay Lieberman Mark Hurtig Denis Evseenko
author_facet	Frank A. Petrigliano Nancy Q. Liu Siyoung Lee Jade Tassey Arijita Sarkar Yucheng Lin Liangliang Li Yifan Yu Dawei Geng Jiankang Zhang Ruzanna Shkhyan Jacob Bogdanov Ben Van Handel Gabriel B. Ferguson Youngjoo Lee Svenja Hinderer Kuo-Chang Tseng Aaron Kavanaugh J. Gage Crump April D. Pyle Katja Schenke-Layland Fabrizio Billi Liming Wang Jay Lieberman Mark Hurtig Denis Evseenko
author_sort	Frank A. Petrigliano
title	Long-term repair of porcine articular cartilage using cryopreservable, clinically compatible human embryonic stem cell-derived chondrocytes
title_short	Long-term repair of porcine articular cartilage using cryopreservable, clinically compatible human embryonic stem cell-derived chondrocytes
title_full	Long-term repair of porcine articular cartilage using cryopreservable, clinically compatible human embryonic stem cell-derived chondrocytes
title_fullStr	Long-term repair of porcine articular cartilage using cryopreservable, clinically compatible human embryonic stem cell-derived chondrocytes
title_full_unstemmed	Long-term repair of porcine articular cartilage using cryopreservable, clinically compatible human embryonic stem cell-derived chondrocytes
title_sort	long-term repair of porcine articular cartilage using cryopreservable, clinically compatible human embryonic stem cell-derived chondrocytes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b8f0ca6279f04f559470bd64f3f242af
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Long-term repair of porcine articular cartilage using cryopreservable, clinically compatible human embryonic stem cell-derived chondrocytes

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