Effect of travoprost on 24-hour intraocular pressure in normal tension glaucoma

Effect of travoprost on 24-hour intraocular pressure in normal tension glaucoma

Yuya Nomura1, Shunsuke Nakakura2, Mitsuyasu Moriwaki1, Yasuhiro Takahashi1, Kunihiko Shiraki11Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, Osaka City University, Japan; 2Department of Ophthalmology, Saiseikai Gose Hospital, JapanPurpose: The effect of travoprost 0.00...

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Autores principales: Yuya Nomura, Shunsuke Nakakura, Mitsuyasu Moriwaki, et al
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2010
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Ophthalmology
RE1-994
Acceso en línea:https://doaj.org/article/b8f4cc3346f24a1c8c0d6265ab354a9e
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spelling oai:doaj.org-article:b8f4cc3346f24a1c8c0d6265ab354a9e2021-12-02T03:55:32ZEffect of travoprost on 24-hour intraocular pressure in normal tension glaucoma1177-54671177-5483https://doaj.org/article/b8f4cc3346f24a1c8c0d6265ab354a9e2010-07-01T00:00:00Zhttp://www.dovepress.com/effect-of-travoprost-on-24-hour-intraocular-pressure-in-normal-tension-a4902https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Yuya Nomura1, Shunsuke Nakakura2, Mitsuyasu Moriwaki1, Yasuhiro Takahashi1, Kunihiko Shiraki11Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, Osaka City University, Japan; 2Department of Ophthalmology, Saiseikai Gose Hospital, JapanPurpose: The effect of travoprost 0.004% on 24-hour intraocular pressure (IOP) was examined in patients with normal tension glaucoma (NTG).Subjects and methods: This study included 17 patients with newly diagnosed unilateral NTG. IOP was measured at three-hour intervals over 24 hours by Goldman applanation tonometer in patients taking topical travoprost 0.004% and was compared retrospectively with 24-hour IOP data in untreated eyes.Results: IOP values were significantly reduced at individual time points after treatment (P < 0.01). Mean 24-hour IOP, maximum 24-hour IOP, minimum 24-hour IOP, and 24-hour IOP fluctuations at baseline (mean ± SD) were 12.9 ± 2.2 mmHg, 15.4 ± 2.7 mmHg, 10.5 ± 2.2 mmHg, and 4.9 ± 1.2 mmHg, respectively, and were significantly reduced to 10.3 ± 2.0 mmHg, 12.4 ± 2.5 mmHg, 8.5 ± 1.9 mmHg (all P < 0.001), and 3.9 ± 1.5 mmHg (P < 0.05), respectively, after treatment. The rate of IOP reduction greater than 20% was 58.8% (10 eyes) for maximum 24-hour IOP and 53.0% (nine eyes) for mean 24-hour IOP.Conclusion: Travoprost reduced IOP throughout the 24-hour study period, with over half of the eyes examined showing IOP reduction exceeding 20%.Keywords: 24-hour intraocular pressure, fluctuation, normal tension glaucoma, travoprost, Travatan Z Yuya NomuraShunsuke NakakuraMitsuyasu Moriwakiet alDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2010, Iss default, Pp 643-647 (2010)
institution DOAJ
collection DOAJ
language EN
topic Ophthalmology
RE1-994
spellingShingle Ophthalmology
RE1-994
Yuya Nomura
Shunsuke Nakakura
Mitsuyasu Moriwaki
et al
Effect of travoprost on 24-hour intraocular pressure in normal tension glaucoma
description Yuya Nomura1, Shunsuke Nakakura2, Mitsuyasu Moriwaki1, Yasuhiro Takahashi1, Kunihiko Shiraki11Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, Osaka City University, Japan; 2Department of Ophthalmology, Saiseikai Gose Hospital, JapanPurpose: The effect of travoprost 0.004% on 24-hour intraocular pressure (IOP) was examined in patients with normal tension glaucoma (NTG).Subjects and methods: This study included 17 patients with newly diagnosed unilateral NTG. IOP was measured at three-hour intervals over 24 hours by Goldman applanation tonometer in patients taking topical travoprost 0.004% and was compared retrospectively with 24-hour IOP data in untreated eyes.Results: IOP values were significantly reduced at individual time points after treatment (P < 0.01). Mean 24-hour IOP, maximum 24-hour IOP, minimum 24-hour IOP, and 24-hour IOP fluctuations at baseline (mean ± SD) were 12.9 ± 2.2 mmHg, 15.4 ± 2.7 mmHg, 10.5 ± 2.2 mmHg, and 4.9 ± 1.2 mmHg, respectively, and were significantly reduced to 10.3 ± 2.0 mmHg, 12.4 ± 2.5 mmHg, 8.5 ± 1.9 mmHg (all P < 0.001), and 3.9 ± 1.5 mmHg (P < 0.05), respectively, after treatment. The rate of IOP reduction greater than 20% was 58.8% (10 eyes) for maximum 24-hour IOP and 53.0% (nine eyes) for mean 24-hour IOP.Conclusion: Travoprost reduced IOP throughout the 24-hour study period, with over half of the eyes examined showing IOP reduction exceeding 20%.Keywords: 24-hour intraocular pressure, fluctuation, normal tension glaucoma, travoprost, Travatan Z
format article
author Yuya Nomura
Shunsuke Nakakura
Mitsuyasu Moriwaki
et al
author_facet Yuya Nomura
Shunsuke Nakakura
Mitsuyasu Moriwaki
et al
author_sort Yuya Nomura
title Effect of travoprost on 24-hour intraocular pressure in normal tension glaucoma
title_short Effect of travoprost on 24-hour intraocular pressure in normal tension glaucoma
title_full Effect of travoprost on 24-hour intraocular pressure in normal tension glaucoma
title_fullStr Effect of travoprost on 24-hour intraocular pressure in normal tension glaucoma
title_full_unstemmed Effect of travoprost on 24-hour intraocular pressure in normal tension glaucoma
title_sort effect of travoprost on 24-hour intraocular pressure in normal tension glaucoma
publisher Dove Medical Press
publishDate 2010
url https://doaj.org/article/b8f4cc3346f24a1c8c0d6265ab354a9e
work_keys_str_mv AT yuyanomura effectoftravoproston24hourintraocularpressureinnormaltensionglaucoma
AT shunsukenakakura effectoftravoproston24hourintraocularpressureinnormaltensionglaucoma
AT mitsuyasumoriwaki effectoftravoproston24hourintraocularpressureinnormaltensionglaucoma
AT etal effectoftravoproston24hourintraocularpressureinnormaltensionglaucoma
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