In silico design and optimization of selective membranolytic anticancer peptides
Abstract Membranolytic anticancer peptides represent a potential strategy in the fight against cancer. However, our understanding of the underlying structure-activity relationships and the mechanisms driving their cell selectivity is still limited. We developed a computational approach as a step tow...
Enregistré dans:
Auteurs principaux: | Gisela Gabernet, Damian Gautschi, Alex T. Müller, Claudia S. Neuhaus, Lucas Armbrecht, Petra S. Dittrich, Jan A. Hiss, Gisbert Schneider |
---|---|
Format: | article |
Langue: | EN |
Publié: |
Nature Portfolio
2019
|
Sujets: | |
Accès en ligne: | https://doaj.org/article/b8f8603aa1a34be985c452e189d9f671 |
Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
Documents similaires
-
Structure-Activity Relationships of Holothuroid’s Triterpene Glycosides and Some In Silico Insights Obtained by Molecular Dynamics Study on the Mechanisms of Their Membranolytic Action
par: Elena A. Zelepuga, et autres
Publié: (2021) -
In silico optimization of a guava antimicrobial peptide enables combinatorial exploration for peptide design
par: William F. Porto, et autres
Publié: (2018) -
Combination of irreversible electroporation with sustained release of a synthetic membranolytic polymer for enhanced cancer cell killing
par: Samuel M. Hanson, et autres
Publié: (2021) -
In Vitro and In Silico Studies of Quercetin and Daidzin as Selective Anticancer Agents
par: Muhammad Sulaiman Zubair, et autres
Publié: (2021) -
In silico approach for predicting toxicity of peptides and proteins.
par: Sudheer Gupta, et autres
Publié: (2013)