The beneficial role of Asian-based RecurIndex test in the prognostic prediction in Chinese male breast cancer patients
Abstract RecurIndex, a multigene profiling assay, can predict the risk of local recurrence and distant metastasis in female breast cancer (FBC), but its role in male breast cancer (MBC) remains unclear. In this study, the clinicopathological data of 43 consecutive MBC patients undergoing surgeries b...
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Nature Portfolio
2021
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oai:doaj.org-article:b8f9bf0eb917417294743488db621f332021-12-02T14:17:19ZThe beneficial role of Asian-based RecurIndex test in the prognostic prediction in Chinese male breast cancer patients10.1038/s41598-021-87267-y2045-2322https://doaj.org/article/b8f9bf0eb917417294743488db621f332021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87267-yhttps://doaj.org/toc/2045-2322Abstract RecurIndex, a multigene profiling assay, can predict the risk of local recurrence and distant metastasis in female breast cancer (FBC), but its role in male breast cancer (MBC) remains unclear. In this study, the clinicopathological data of 43 consecutive MBC patients undergoing surgeries between 2009 and 2018 were retrospectively analysed. Their paraffin-embedded tissue sections were examined by RecurIndex test which comprised 2 models: recurrence index for local recurrence (RI-LR) and recurrence index for distant recurrence (RI-DR). Of 43 patients, there were 26 low-risk and 17 high-risk patients assessed by RI-LR, while 17 low-risk and 26 high-risk patients by RI-DR. For RI-LR, tumor N stage showed statistically significant (P < 0.001) between low- and high-risk patients; for RI-DR, differences were pronounced in tumor grade (P = 0.033), T stage (P = 0.043) and N stage (P = 0.003). In terms of clinical outcomes, the overall survival (OS) of low- and high-risk patients stratified by RI-LR showed no statistically significant differences (P = 0.460), while high-risk patients identified by RI-DR had a significantly worse distant recurrence-free survival (DRFS) (P = 0.035), progression-free survival (PFS) (P = 0.019) and OS (P = 0.044) than low-risk patients. Overall, RI-DR can effectively predict the DRFS, PFS and OS of MBC patients and identify those at low risk of recurrence, which may serve as a potential prognostic tool for MBC.Shuo ZhangBeichen LiuMengli ZhouJintian WangJinzhao LiuLi WangChao YangYueping LiuShuyao NiuFurong DuXiaohua DuNing WangJiyu TangChao SongYunjiang LiuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021) |
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Medicine R Science Q Shuo Zhang Beichen Liu Mengli Zhou Jintian Wang Jinzhao Liu Li Wang Chao Yang Yueping Liu Shuyao Niu Furong Du Xiaohua Du Ning Wang Jiyu Tang Chao Song Yunjiang Liu The beneficial role of Asian-based RecurIndex test in the prognostic prediction in Chinese male breast cancer patients |
| description |
Abstract RecurIndex, a multigene profiling assay, can predict the risk of local recurrence and distant metastasis in female breast cancer (FBC), but its role in male breast cancer (MBC) remains unclear. In this study, the clinicopathological data of 43 consecutive MBC patients undergoing surgeries between 2009 and 2018 were retrospectively analysed. Their paraffin-embedded tissue sections were examined by RecurIndex test which comprised 2 models: recurrence index for local recurrence (RI-LR) and recurrence index for distant recurrence (RI-DR). Of 43 patients, there were 26 low-risk and 17 high-risk patients assessed by RI-LR, while 17 low-risk and 26 high-risk patients by RI-DR. For RI-LR, tumor N stage showed statistically significant (P < 0.001) between low- and high-risk patients; for RI-DR, differences were pronounced in tumor grade (P = 0.033), T stage (P = 0.043) and N stage (P = 0.003). In terms of clinical outcomes, the overall survival (OS) of low- and high-risk patients stratified by RI-LR showed no statistically significant differences (P = 0.460), while high-risk patients identified by RI-DR had a significantly worse distant recurrence-free survival (DRFS) (P = 0.035), progression-free survival (PFS) (P = 0.019) and OS (P = 0.044) than low-risk patients. Overall, RI-DR can effectively predict the DRFS, PFS and OS of MBC patients and identify those at low risk of recurrence, which may serve as a potential prognostic tool for MBC. |
| format |
article |
| author |
Shuo Zhang Beichen Liu Mengli Zhou Jintian Wang Jinzhao Liu Li Wang Chao Yang Yueping Liu Shuyao Niu Furong Du Xiaohua Du Ning Wang Jiyu Tang Chao Song Yunjiang Liu |
| author_facet |
Shuo Zhang Beichen Liu Mengli Zhou Jintian Wang Jinzhao Liu Li Wang Chao Yang Yueping Liu Shuyao Niu Furong Du Xiaohua Du Ning Wang Jiyu Tang Chao Song Yunjiang Liu |
| author_sort |
Shuo Zhang |
| title |
The beneficial role of Asian-based RecurIndex test in the prognostic prediction in Chinese male breast cancer patients |
| title_short |
The beneficial role of Asian-based RecurIndex test in the prognostic prediction in Chinese male breast cancer patients |
| title_full |
The beneficial role of Asian-based RecurIndex test in the prognostic prediction in Chinese male breast cancer patients |
| title_fullStr |
The beneficial role of Asian-based RecurIndex test in the prognostic prediction in Chinese male breast cancer patients |
| title_full_unstemmed |
The beneficial role of Asian-based RecurIndex test in the prognostic prediction in Chinese male breast cancer patients |
| title_sort |
beneficial role of asian-based recurindex test in the prognostic prediction in chinese male breast cancer patients |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/b8f9bf0eb917417294743488db621f33 |
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