Cholecystectomy and subsequent risk of Parkinson’s disease: a nationwide retrospective cohort study

Abstract Growing evidence has suggested that the gut-brain axis plays an important role in the pathogenesis of Parkinson’s disease (PD), and that this role is mediated by the interactions between bile acids (BAs) and intestinal microbiota. Given that cholecystectomy can lead to alterations in BAs an...

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Autores principales:	Ryul Kim, Jee-Young Lee, Sanghyun Park, Kyungdo Han, Cheol Min Shin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/b900a3fd4e8a411595a94d225f948fca
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spelling	oai:doaj.org-article:b900a3fd4e8a411595a94d225f948fca2021-11-21T12:26:43ZCholecystectomy and subsequent risk of Parkinson’s disease: a nationwide retrospective cohort study10.1038/s41531-021-00245-z2373-8057https://doaj.org/article/b900a3fd4e8a411595a94d225f948fca2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41531-021-00245-zhttps://doaj.org/toc/2373-8057Abstract Growing evidence has suggested that the gut-brain axis plays an important role in the pathogenesis of Parkinson’s disease (PD), and that this role is mediated by the interactions between bile acids (BAs) and intestinal microbiota. Given that cholecystectomy can lead to alterations in BAs and gut microbiota, we investigated whether cholecystectomy is linked to a higher risk of PD. We constructed a cohort of patients with an operation code of cholecystectomy from 2010 to 2015 (n = 161,838) and age- and sex-matched control subjects without cholecystectomy (n = 286,135) using the National Health Insurance Service database. Incident PD was traced over a maximum observation period of 7 years. We identified 1404 incident PD cases during 1,631,265 person-years of follow-up. The cholecystectomy group showed an elevated risk of PD compared to the control group, even after adjusting for potential confounding factors (adjusted hazard ratio [HR] 1.14, 95% confidence interval [CI] 1.02–1.27). When the data were split by sex, the risk elevation was significant in men (adjusted HR 1.22, 95% CI 1.06–1.41), but not in women (adjusted HR 1.03, 95% CI 0.88–1.22). Our results provide evidence that cholecystectomy is associated with an increased risk of developing PD. This association differed between men and women, suggesting sex-specific effects of cholecystectomy on the risk of PD.Ryul KimJee-Young LeeSanghyun ParkKyungdo HanCheol Min ShinNature PortfolioarticleNeurology. Diseases of the nervous systemRC346-429ENnpj Parkinson's Disease, Vol 7, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurology. Diseases of the nervous system RC346-429 Ryul Kim Jee-Young Lee Sanghyun Park Kyungdo Han Cheol Min Shin Cholecystectomy and subsequent risk of Parkinson’s disease: a nationwide retrospective cohort study
description	Abstract Growing evidence has suggested that the gut-brain axis plays an important role in the pathogenesis of Parkinson’s disease (PD), and that this role is mediated by the interactions between bile acids (BAs) and intestinal microbiota. Given that cholecystectomy can lead to alterations in BAs and gut microbiota, we investigated whether cholecystectomy is linked to a higher risk of PD. We constructed a cohort of patients with an operation code of cholecystectomy from 2010 to 2015 (n = 161,838) and age- and sex-matched control subjects without cholecystectomy (n = 286,135) using the National Health Insurance Service database. Incident PD was traced over a maximum observation period of 7 years. We identified 1404 incident PD cases during 1,631,265 person-years of follow-up. The cholecystectomy group showed an elevated risk of PD compared to the control group, even after adjusting for potential confounding factors (adjusted hazard ratio [HR] 1.14, 95% confidence interval [CI] 1.02–1.27). When the data were split by sex, the risk elevation was significant in men (adjusted HR 1.22, 95% CI 1.06–1.41), but not in women (adjusted HR 1.03, 95% CI 0.88–1.22). Our results provide evidence that cholecystectomy is associated with an increased risk of developing PD. This association differed between men and women, suggesting sex-specific effects of cholecystectomy on the risk of PD.
format	article
author	Ryul Kim Jee-Young Lee Sanghyun Park Kyungdo Han Cheol Min Shin
author_facet	Ryul Kim Jee-Young Lee Sanghyun Park Kyungdo Han Cheol Min Shin
author_sort	Ryul Kim
title	Cholecystectomy and subsequent risk of Parkinson’s disease: a nationwide retrospective cohort study
title_short	Cholecystectomy and subsequent risk of Parkinson’s disease: a nationwide retrospective cohort study
title_full	Cholecystectomy and subsequent risk of Parkinson’s disease: a nationwide retrospective cohort study
title_fullStr	Cholecystectomy and subsequent risk of Parkinson’s disease: a nationwide retrospective cohort study
title_full_unstemmed	Cholecystectomy and subsequent risk of Parkinson’s disease: a nationwide retrospective cohort study
title_sort	cholecystectomy and subsequent risk of parkinson’s disease: a nationwide retrospective cohort study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b900a3fd4e8a411595a94d225f948fca
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Cholecystectomy and subsequent risk of Parkinson’s disease: a nationwide retrospective cohort study

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