A chemical biology toolbox to study protein methyltransferases and epigenetic signaling

Protein methyltransferases (PMTs) are epigenetic regulatory enzymes with significant therapeutic relevance. Here the authors describe a collection of chemical inhibitors and antagonists to modulate most of the key methylation marks on histones H3 and H4, and use the collection to study of the role o...

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Autores principales:	Sebastian Scheer, Suzanne Ackloo, Tiago S. Medina, Matthieu Schapira, Fengling Li, Jennifer A. Ward, Andrew M. Lewis, Jeffrey P. Northrop, Paul L. Richardson, H. Ümit Kaniskan, Yudao Shen, Jing Liu, David Smil, David McLeod, Carlos A. Zepeda-Velazquez, Minkui Luo, Jian Jin, Dalia Barsyte-Lovejoy, Kilian V. M. Huber, Daniel D. De Carvalho, Masoud Vedadi, Colby Zaph, Peter J. Brown, Cheryl H. Arrowsmith
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b9017f82fb1d46769b1e67347ec72d39
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spelling	oai:doaj.org-article:b9017f82fb1d46769b1e67347ec72d392021-12-02T17:02:07ZA chemical biology toolbox to study protein methyltransferases and epigenetic signaling10.1038/s41467-018-07905-42041-1723https://doaj.org/article/b9017f82fb1d46769b1e67347ec72d392019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07905-4https://doaj.org/toc/2041-1723Protein methyltransferases (PMTs) are epigenetic regulatory enzymes with significant therapeutic relevance. Here the authors describe a collection of chemical inhibitors and antagonists to modulate most of the key methylation marks on histones H3 and H4, and use the collection to study of the role of PMTs in mouse and human T cell differentiation.Sebastian ScheerSuzanne AcklooTiago S. MedinaMatthieu SchapiraFengling LiJennifer A. WardAndrew M. LewisJeffrey P. NorthropPaul L. RichardsonH. Ümit KaniskanYudao ShenJing LiuDavid SmilDavid McLeodCarlos A. Zepeda-VelazquezMinkui LuoJian JinDalia Barsyte-LovejoyKilian V. M. HuberDaniel D. De CarvalhoMasoud VedadiColby ZaphPeter J. BrownCheryl H. ArrowsmithNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sebastian Scheer Suzanne Ackloo Tiago S. Medina Matthieu Schapira Fengling Li Jennifer A. Ward Andrew M. Lewis Jeffrey P. Northrop Paul L. Richardson H. Ümit Kaniskan Yudao Shen Jing Liu David Smil David McLeod Carlos A. Zepeda-Velazquez Minkui Luo Jian Jin Dalia Barsyte-Lovejoy Kilian V. M. Huber Daniel D. De Carvalho Masoud Vedadi Colby Zaph Peter J. Brown Cheryl H. Arrowsmith A chemical biology toolbox to study protein methyltransferases and epigenetic signaling
description	Protein methyltransferases (PMTs) are epigenetic regulatory enzymes with significant therapeutic relevance. Here the authors describe a collection of chemical inhibitors and antagonists to modulate most of the key methylation marks on histones H3 and H4, and use the collection to study of the role of PMTs in mouse and human T cell differentiation.
format	article
author	Sebastian Scheer Suzanne Ackloo Tiago S. Medina Matthieu Schapira Fengling Li Jennifer A. Ward Andrew M. Lewis Jeffrey P. Northrop Paul L. Richardson H. Ümit Kaniskan Yudao Shen Jing Liu David Smil David McLeod Carlos A. Zepeda-Velazquez Minkui Luo Jian Jin Dalia Barsyte-Lovejoy Kilian V. M. Huber Daniel D. De Carvalho Masoud Vedadi Colby Zaph Peter J. Brown Cheryl H. Arrowsmith
author_facet	Sebastian Scheer Suzanne Ackloo Tiago S. Medina Matthieu Schapira Fengling Li Jennifer A. Ward Andrew M. Lewis Jeffrey P. Northrop Paul L. Richardson H. Ümit Kaniskan Yudao Shen Jing Liu David Smil David McLeod Carlos A. Zepeda-Velazquez Minkui Luo Jian Jin Dalia Barsyte-Lovejoy Kilian V. M. Huber Daniel D. De Carvalho Masoud Vedadi Colby Zaph Peter J. Brown Cheryl H. Arrowsmith
author_sort	Sebastian Scheer
title	A chemical biology toolbox to study protein methyltransferases and epigenetic signaling
title_short	A chemical biology toolbox to study protein methyltransferases and epigenetic signaling
title_full	A chemical biology toolbox to study protein methyltransferases and epigenetic signaling
title_fullStr	A chemical biology toolbox to study protein methyltransferases and epigenetic signaling
title_full_unstemmed	A chemical biology toolbox to study protein methyltransferases and epigenetic signaling
title_sort	chemical biology toolbox to study protein methyltransferases and epigenetic signaling
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/b9017f82fb1d46769b1e67347ec72d39
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A chemical biology toolbox to study protein methyltransferases and epigenetic signaling

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