Genetic risk score of NOS gene variants associated with myocardial infarction correlates with coronary incidence across Europe.

Coronary artery disease (CAD) mortality and morbidity is present in the European continent in a four-fold gradient across populations, from the South (Spain and France) with the lowest CAD mortality, towards the North (Finland and UK). This observed gradient has not been fully explained by classical...

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Autores principales:	Robert Carreras-Torres, Suman Kundu, Daniela Zanetti, Esther Esteban, Marc Via, Pedro Moral
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b901cd7149d6404396dd7da6540c01c3
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spelling	oai:doaj.org-article:b901cd7149d6404396dd7da6540c01c32021-11-18T08:20:20ZGenetic risk score of NOS gene variants associated with myocardial infarction correlates with coronary incidence across Europe.1932-620310.1371/journal.pone.0096504https://doaj.org/article/b901cd7149d6404396dd7da6540c01c32014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24806096/?tool=EBIhttps://doaj.org/toc/1932-6203Coronary artery disease (CAD) mortality and morbidity is present in the European continent in a four-fold gradient across populations, from the South (Spain and France) with the lowest CAD mortality, towards the North (Finland and UK). This observed gradient has not been fully explained by classical or single genetic risk factors, resulting in some cases in the so called Southern European or Mediterranean paradox. Here we approached population genetic risk estimates using genetic risk scores (GRS) constructed with single nucleotide polymorphisms (SNP) from nitric oxide synthases (NOS) genes. These SNPs appeared to be associated with myocardial infarction (MI) in 2165 cases and 2153 controls. The GRSs were computed in 34 general European populations. Although the contribution of these GRS was lower than 1% between cases and controls, the mean GRS per population was positively correlated with coronary incidence explaining 65-85% of the variation among populations (67% in women and 86% in men). This large contribution to CAD incidence variation among populations might be a result of colinearity with several other common genetic and environmental factors. These results are not consistent with the cardiovascular Mediterranean paradox for genetics and support a CAD genetic architecture mainly based on combinations of common genetic polymorphisms. Population genetic risk scores is a promising approach in public health interventions to develop lifestyle programs and prevent intermediate risk factors in certain subpopulations with specific genetic predisposition.Robert Carreras-TorresSuman KunduDaniela ZanettiEsther EstebanMarc ViaPedro MoralPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 5, p e96504 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Robert Carreras-Torres Suman Kundu Daniela Zanetti Esther Esteban Marc Via Pedro Moral Genetic risk score of NOS gene variants associated with myocardial infarction correlates with coronary incidence across Europe.
description	Coronary artery disease (CAD) mortality and morbidity is present in the European continent in a four-fold gradient across populations, from the South (Spain and France) with the lowest CAD mortality, towards the North (Finland and UK). This observed gradient has not been fully explained by classical or single genetic risk factors, resulting in some cases in the so called Southern European or Mediterranean paradox. Here we approached population genetic risk estimates using genetic risk scores (GRS) constructed with single nucleotide polymorphisms (SNP) from nitric oxide synthases (NOS) genes. These SNPs appeared to be associated with myocardial infarction (MI) in 2165 cases and 2153 controls. The GRSs were computed in 34 general European populations. Although the contribution of these GRS was lower than 1% between cases and controls, the mean GRS per population was positively correlated with coronary incidence explaining 65-85% of the variation among populations (67% in women and 86% in men). This large contribution to CAD incidence variation among populations might be a result of colinearity with several other common genetic and environmental factors. These results are not consistent with the cardiovascular Mediterranean paradox for genetics and support a CAD genetic architecture mainly based on combinations of common genetic polymorphisms. Population genetic risk scores is a promising approach in public health interventions to develop lifestyle programs and prevent intermediate risk factors in certain subpopulations with specific genetic predisposition.
format	article
author	Robert Carreras-Torres Suman Kundu Daniela Zanetti Esther Esteban Marc Via Pedro Moral
author_facet	Robert Carreras-Torres Suman Kundu Daniela Zanetti Esther Esteban Marc Via Pedro Moral
author_sort	Robert Carreras-Torres
title	Genetic risk score of NOS gene variants associated with myocardial infarction correlates with coronary incidence across Europe.
title_short	Genetic risk score of NOS gene variants associated with myocardial infarction correlates with coronary incidence across Europe.
title_full	Genetic risk score of NOS gene variants associated with myocardial infarction correlates with coronary incidence across Europe.
title_fullStr	Genetic risk score of NOS gene variants associated with myocardial infarction correlates with coronary incidence across Europe.
title_full_unstemmed	Genetic risk score of NOS gene variants associated with myocardial infarction correlates with coronary incidence across Europe.
title_sort	genetic risk score of nos gene variants associated with myocardial infarction correlates with coronary incidence across europe.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/b901cd7149d6404396dd7da6540c01c3
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Genetic risk score of NOS gene variants associated with myocardial infarction correlates with coronary incidence across Europe.

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