Understanding Hyaluronan Receptor (CD44) Interaction, HA-CD44 Activated Potential Targets in Cancer Therapeutics

Cancer is a complex mechanism involving a series of cellular events. The glycoproteins such as hyaluronan (HA) are a significant element of extracellular matrix (ECM), involve in the onset of cancer developmental process. The pivotal roles of HA in cancer progression depend on dysregulated expressio...

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Autores principales:	Gul-e-Saba Chaudhry, Abdah Akim, Muhammad Naveed Zafar, Naila Safdar, Yeong Yik Sung, Tengku Sifzizul Tengku Muhammad
Formato:	article
Lenguaje:	EN
Publicado:	Tabriz University of Medical Sciences 2020
Materias:	apoptosis cancer pathways cd44 cell proliferation hyaluronan targeted therapeutics tumor progression nanotechnology Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/b9068a3dba5b4993b03cd39078e01767
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spelling	oai:doaj.org-article:b9068a3dba5b4993b03cd39078e017672021-12-05T09:40:16ZUnderstanding Hyaluronan Receptor (CD44) Interaction, HA-CD44 Activated Potential Targets in Cancer Therapeutics2228-58812251-730810.34172/apb.2021.050https://doaj.org/article/b9068a3dba5b4993b03cd39078e017672020-07-01T00:00:00Zhttps://apb.tbzmed.ac.ir/PDF/apb-11-426.pdfhttps://doaj.org/toc/2228-5881https://doaj.org/toc/2251-7308Cancer is a complex mechanism involving a series of cellular events. The glycoproteins such as hyaluronan (HA) are a significant element of extracellular matrix (ECM), involve in the onset of cancer developmental process. The pivotal roles of HA in cancer progression depend on dysregulated expression in various cancer. HA, also gain attention due to consideration as a primary ligand of CD44 receptor. The CD44, complex transmembrane receptor protein, due to alternative splicing in the transcription process, various CD44 isoforms predominantly exist. The overexpression of distinct CD44 isoforms (CD44v) standard (CD44s) depends on the tumour type and stage. The receptor proteins, CD44 engage in a variety of biological processes, including cell growth, apoptosis, migration, and angiogenesis. HA-CD44 interaction trigger survival pathways that result in cell proliferation, invasion ultimately complex metastasis. The interaction and binding of ligand-receptor HA-CD44 regulate the downstream cytoskeleton pathways involve in cell survival or cell death. Thus, targeting HA, CD44 (variant and standard) isoform, and HA-CD44 binding consider as an attractive and useful approach towards cancer therapeutics. The use of various inhibitors of HA, hyaluronidases (HYALs), and utilizing targeted Nano-delivery of anticancer agents and antibodies against CD44, peptides gives promising results in vitro and in vivo. However, they are in clinical trials with favourable and unfavourable outcomes, which reflects the need for various modifications in targeting agents and a better understanding of potential targets in tumour progression pathways.Gul-e-Saba ChaudhryAbdah AkimMuhammad Naveed ZafarNaila SafdarYeong Yik SungTengku Sifzizul Tengku MuhammadTabriz University of Medical Sciences articleapoptosiscancer pathwayscd44cell proliferationhyaluronantargeted therapeuticstumor progressionnanotechnologyTherapeutics. PharmacologyRM1-950ENAdvanced Pharmaceutical Bulletin, Vol 11, Iss 3, Pp 426-438 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	apoptosis cancer pathways cd44 cell proliferation hyaluronan targeted therapeutics tumor progression nanotechnology Therapeutics. Pharmacology RM1-950
spellingShingle	apoptosis cancer pathways cd44 cell proliferation hyaluronan targeted therapeutics tumor progression nanotechnology Therapeutics. Pharmacology RM1-950 Gul-e-Saba Chaudhry Abdah Akim Muhammad Naveed Zafar Naila Safdar Yeong Yik Sung Tengku Sifzizul Tengku Muhammad Understanding Hyaluronan Receptor (CD44) Interaction, HA-CD44 Activated Potential Targets in Cancer Therapeutics
description	Cancer is a complex mechanism involving a series of cellular events. The glycoproteins such as hyaluronan (HA) are a significant element of extracellular matrix (ECM), involve in the onset of cancer developmental process. The pivotal roles of HA in cancer progression depend on dysregulated expression in various cancer. HA, also gain attention due to consideration as a primary ligand of CD44 receptor. The CD44, complex transmembrane receptor protein, due to alternative splicing in the transcription process, various CD44 isoforms predominantly exist. The overexpression of distinct CD44 isoforms (CD44v) standard (CD44s) depends on the tumour type and stage. The receptor proteins, CD44 engage in a variety of biological processes, including cell growth, apoptosis, migration, and angiogenesis. HA-CD44 interaction trigger survival pathways that result in cell proliferation, invasion ultimately complex metastasis. The interaction and binding of ligand-receptor HA-CD44 regulate the downstream cytoskeleton pathways involve in cell survival or cell death. Thus, targeting HA, CD44 (variant and standard) isoform, and HA-CD44 binding consider as an attractive and useful approach towards cancer therapeutics. The use of various inhibitors of HA, hyaluronidases (HYALs), and utilizing targeted Nano-delivery of anticancer agents and antibodies against CD44, peptides gives promising results in vitro and in vivo. However, they are in clinical trials with favourable and unfavourable outcomes, which reflects the need for various modifications in targeting agents and a better understanding of potential targets in tumour progression pathways.
format	article
author	Gul-e-Saba Chaudhry Abdah Akim Muhammad Naveed Zafar Naila Safdar Yeong Yik Sung Tengku Sifzizul Tengku Muhammad
author_facet	Gul-e-Saba Chaudhry Abdah Akim Muhammad Naveed Zafar Naila Safdar Yeong Yik Sung Tengku Sifzizul Tengku Muhammad
author_sort	Gul-e-Saba Chaudhry
title	Understanding Hyaluronan Receptor (CD44) Interaction, HA-CD44 Activated Potential Targets in Cancer Therapeutics
title_short	Understanding Hyaluronan Receptor (CD44) Interaction, HA-CD44 Activated Potential Targets in Cancer Therapeutics
title_full	Understanding Hyaluronan Receptor (CD44) Interaction, HA-CD44 Activated Potential Targets in Cancer Therapeutics
title_fullStr	Understanding Hyaluronan Receptor (CD44) Interaction, HA-CD44 Activated Potential Targets in Cancer Therapeutics
title_full_unstemmed	Understanding Hyaluronan Receptor (CD44) Interaction, HA-CD44 Activated Potential Targets in Cancer Therapeutics
title_sort	understanding hyaluronan receptor (cd44) interaction, ha-cd44 activated potential targets in cancer therapeutics
publisher	Tabriz University of Medical Sciences
publishDate	2020
url	https://doaj.org/article/b9068a3dba5b4993b03cd39078e01767
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Understanding Hyaluronan Receptor (CD44) Interaction, HA-CD44 Activated Potential Targets in Cancer Therapeutics

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