Highlighting the Place of Metastasis-Directed Therapy in Isolated Liver Metastases in Prostate Cancer: A Case Report

Metastatic prostate cancer remains a challenge for clinicians. Metastases involve mainly the bone compartment and can manifest as oligometastatic disease. In this setting, the role of metastasis-directed therapies (MDT) including surgery and/or stereotactic body radiotherapy is currently evaluated....

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Autores principales:	Anne-Emmanuella Yeo, Aurore Hendrix, Caterina Confente, Nicolas Christian, Baudouin Mansvelt, Géraldine Pairet, Emmanuel Seront
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	metastasis-directed therapy liver metastasis oligometastatic prostate cancer abiraterone acetate case report Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/b90790968d3b4f01a901ac349ae313f9
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id	oai:doaj.org-article:b90790968d3b4f01a901ac349ae313f9
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spelling	oai:doaj.org-article:b90790968d3b4f01a901ac349ae313f92021-11-17T05:32:12ZHighlighting the Place of Metastasis-Directed Therapy in Isolated Liver Metastases in Prostate Cancer: A Case Report2234-943X10.3389/fonc.2021.764758https://doaj.org/article/b90790968d3b4f01a901ac349ae313f92021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.764758/fullhttps://doaj.org/toc/2234-943XMetastatic prostate cancer remains a challenge for clinicians. Metastases involve mainly the bone compartment and can manifest as oligometastatic disease. In this setting, the role of metastasis-directed therapies (MDT) including surgery and/or stereotactic body radiotherapy is currently evaluated. Visceral metastases are less common and have very poor prognosis in mPC. Whether treating isolated visceral metastases such as liver metastases with MDT could increase the prognosis remains unknown. We report the management of a prostate cancer patient who progressed on androgen deprivation therapy with apparition of two liver metastases. We describe the feasibility of combining MDT with abiraterone acetate and prednisone in a patient with metastatic castration-resistant prostate cancer. MDT allowed the interruption of abiraterone acetate, preventing cumulative toxicity of this agent.Anne-Emmanuella YeoAurore HendrixCaterina ConfenteNicolas ChristianBaudouin MansveltGéraldine PairetEmmanuel SerontFrontiers Media S.A.articlemetastasis-directed therapyliver metastasisoligometastaticprostate cancerabiraterone acetatecase reportNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	metastasis-directed therapy liver metastasis oligometastatic prostate cancer abiraterone acetate case report Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	metastasis-directed therapy liver metastasis oligometastatic prostate cancer abiraterone acetate case report Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Anne-Emmanuella Yeo Aurore Hendrix Caterina Confente Nicolas Christian Baudouin Mansvelt Géraldine Pairet Emmanuel Seront Highlighting the Place of Metastasis-Directed Therapy in Isolated Liver Metastases in Prostate Cancer: A Case Report
description	Metastatic prostate cancer remains a challenge for clinicians. Metastases involve mainly the bone compartment and can manifest as oligometastatic disease. In this setting, the role of metastasis-directed therapies (MDT) including surgery and/or stereotactic body radiotherapy is currently evaluated. Visceral metastases are less common and have very poor prognosis in mPC. Whether treating isolated visceral metastases such as liver metastases with MDT could increase the prognosis remains unknown. We report the management of a prostate cancer patient who progressed on androgen deprivation therapy with apparition of two liver metastases. We describe the feasibility of combining MDT with abiraterone acetate and prednisone in a patient with metastatic castration-resistant prostate cancer. MDT allowed the interruption of abiraterone acetate, preventing cumulative toxicity of this agent.
format	article
author	Anne-Emmanuella Yeo Aurore Hendrix Caterina Confente Nicolas Christian Baudouin Mansvelt Géraldine Pairet Emmanuel Seront
author_facet	Anne-Emmanuella Yeo Aurore Hendrix Caterina Confente Nicolas Christian Baudouin Mansvelt Géraldine Pairet Emmanuel Seront
author_sort	Anne-Emmanuella Yeo
title	Highlighting the Place of Metastasis-Directed Therapy in Isolated Liver Metastases in Prostate Cancer: A Case Report
title_short	Highlighting the Place of Metastasis-Directed Therapy in Isolated Liver Metastases in Prostate Cancer: A Case Report
title_full	Highlighting the Place of Metastasis-Directed Therapy in Isolated Liver Metastases in Prostate Cancer: A Case Report
title_fullStr	Highlighting the Place of Metastasis-Directed Therapy in Isolated Liver Metastases in Prostate Cancer: A Case Report
title_full_unstemmed	Highlighting the Place of Metastasis-Directed Therapy in Isolated Liver Metastases in Prostate Cancer: A Case Report
title_sort	highlighting the place of metastasis-directed therapy in isolated liver metastases in prostate cancer: a case report
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/b90790968d3b4f01a901ac349ae313f9
work_keys_str_mv	AT anneemmanuellayeo highlightingtheplaceofmetastasisdirectedtherapyinisolatedlivermetastasesinprostatecanceracasereport AT aurorehendrix highlightingtheplaceofmetastasisdirectedtherapyinisolatedlivermetastasesinprostatecanceracasereport AT caterinaconfente highlightingtheplaceofmetastasisdirectedtherapyinisolatedlivermetastasesinprostatecanceracasereport AT nicolaschristian highlightingtheplaceofmetastasisdirectedtherapyinisolatedlivermetastasesinprostatecanceracasereport AT baudouinmansvelt highlightingtheplaceofmetastasisdirectedtherapyinisolatedlivermetastasesinprostatecanceracasereport AT geraldinepairet highlightingtheplaceofmetastasisdirectedtherapyinisolatedlivermetastasesinprostatecanceracasereport AT emmanuelseront highlightingtheplaceofmetastasisdirectedtherapyinisolatedlivermetastasesinprostatecanceracasereport
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Highlighting the Place of Metastasis-Directed Therapy in Isolated Liver Metastases in Prostate Cancer: A Case Report

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