The antidiabetic effects of a dry powder of dietary vegetable and fruit mixtures in diabetic db/db mice

Chung-Man Yeung1, Yi Tan1, Sidney Tam2, Liwei Lu3, King-Hung Ko3, Pai-Hao Yang1,4, Hsiang-Fu Kung4, Marie C Lin11Department of Chemistry, Open Laboratory of Chemical Biology of the Institute of Molecular Technology,&nbsp;2Clinical Biochemistry Unit, 3Department of Pathology, The University o...

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Autores principales:	Chung-Man Yeung, Yi Tan, Sidney Tam, Liwei Lu, King-Hung Ko, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/b907c5f403c1498998b4bee6be778da6
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spelling	oai:doaj.org-article:b907c5f403c1498998b4bee6be778da62021-12-02T00:50:25ZThe antidiabetic effects of a dry powder of dietary vegetable and fruit mixtures in diabetic db/db mice1177-54751177-5491https://doaj.org/article/b907c5f403c1498998b4bee6be778da62008-09-01T00:00:00Zhttp://www.dovepress.com/the-antidiabetic-effects-of-a-dry-powder-of-dietary-vegetable-and-frui-a2306https://doaj.org/toc/1177-5475https://doaj.org/toc/1177-5491Chung-Man Yeung1, Yi Tan1, Sidney Tam2, Liwei Lu3, King-Hung Ko3, Pai-Hao Yang1,4, Hsiang-Fu Kung4, Marie C Lin11Department of Chemistry, Open Laboratory of Chemical Biology of the Institute of Molecular Technology,&nbsp;2Clinical Biochemistry Unit, 3Department of Pathology, The University of Hong Kong, Hong Kong, China; 4Centre of Emerging Infectious Diseases, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, ChinaAbstract: We evaluated the antidiabetic effects of a mixed vegetable powder-formula I (MVP-FI), which is a dry powder mixture of over 65 kinds of vegetables and fruits, using the db/db type 2 diabetes mouse model. The db/db mice at 8&ndash;10 weeks of age were randomly divided into three groups: vehicle treatment, 1.575 g/kg MVP-FI treatment, and 3.15 g/kg MVP-FI treatment. During 12 days of treatment, we measured food intake and body weight changes, fasting blood glucose levels, and plasma lipid levels. Our results showed that the food intake and the body weight of MVP-FI-treated group were decreased gradually. Moreover, the fasting blood glucose level of the treated group was significantly dropped to a normal level comparable to that of the lean mice. Furthermore, we also found that the plasma triglyceride level in the treated group was dropped, whereas the high-density lipoprotein (HDL) level was increased and total cholesterol/HDL-cholesterol ratio was decreased. Taken together, these results suggest that the diabetic conditions of the db/db mice have been improved after 12 days treatment with MVP-FI. The antihyperglycemic and antiobese activities of the MVP-FI, as demonstrated in the present study, may have important clinical implications for improving the management of type 2 diabetic patients.Keywords: traditional Chinese medicine (TCM), db/db mice, diabetes Chung-Man YeungYi TanSidney TamLiwei LuKing-Hung Koet alDove Medical PressarticleMedicine (General)R5-920ENBiologics: Targets & Therapy, Vol 2008, Iss Issue 3, Pp 571-576 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Chung-Man Yeung Yi Tan Sidney Tam Liwei Lu King-Hung Ko et al The antidiabetic effects of a dry powder of dietary vegetable and fruit mixtures in diabetic db/db mice
description	Chung-Man Yeung1, Yi Tan1, Sidney Tam2, Liwei Lu3, King-Hung Ko3, Pai-Hao Yang1,4, Hsiang-Fu Kung4, Marie C Lin11Department of Chemistry, Open Laboratory of Chemical Biology of the Institute of Molecular Technology,&nbsp;2Clinical Biochemistry Unit, 3Department of Pathology, The University of Hong Kong, Hong Kong, China; 4Centre of Emerging Infectious Diseases, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, ChinaAbstract: We evaluated the antidiabetic effects of a mixed vegetable powder-formula I (MVP-FI), which is a dry powder mixture of over 65 kinds of vegetables and fruits, using the db/db type 2 diabetes mouse model. The db/db mice at 8&ndash;10 weeks of age were randomly divided into three groups: vehicle treatment, 1.575 g/kg MVP-FI treatment, and 3.15 g/kg MVP-FI treatment. During 12 days of treatment, we measured food intake and body weight changes, fasting blood glucose levels, and plasma lipid levels. Our results showed that the food intake and the body weight of MVP-FI-treated group were decreased gradually. Moreover, the fasting blood glucose level of the treated group was significantly dropped to a normal level comparable to that of the lean mice. Furthermore, we also found that the plasma triglyceride level in the treated group was dropped, whereas the high-density lipoprotein (HDL) level was increased and total cholesterol/HDL-cholesterol ratio was decreased. Taken together, these results suggest that the diabetic conditions of the db/db mice have been improved after 12 days treatment with MVP-FI. The antihyperglycemic and antiobese activities of the MVP-FI, as demonstrated in the present study, may have important clinical implications for improving the management of type 2 diabetic patients.Keywords: traditional Chinese medicine (TCM), db/db mice, diabetes
format	article
author	Chung-Man Yeung Yi Tan Sidney Tam Liwei Lu King-Hung Ko et al
author_facet	Chung-Man Yeung Yi Tan Sidney Tam Liwei Lu King-Hung Ko et al
author_sort	Chung-Man Yeung
title	The antidiabetic effects of a dry powder of dietary vegetable and fruit mixtures in diabetic db/db mice
title_short	The antidiabetic effects of a dry powder of dietary vegetable and fruit mixtures in diabetic db/db mice
title_full	The antidiabetic effects of a dry powder of dietary vegetable and fruit mixtures in diabetic db/db mice
title_fullStr	The antidiabetic effects of a dry powder of dietary vegetable and fruit mixtures in diabetic db/db mice
title_full_unstemmed	The antidiabetic effects of a dry powder of dietary vegetable and fruit mixtures in diabetic db/db mice
title_sort	antidiabetic effects of a dry powder of dietary vegetable and fruit mixtures in diabetic db/db mice
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/b907c5f403c1498998b4bee6be778da6
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The antidiabetic effects of a dry powder of dietary vegetable and fruit mixtures in diabetic db/db mice

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