Ethnicity influences the gut microbiota of individuals sharing a geographical location: a cross-sectional study from a middle-income country

Abstract No studies have investigated the influence of ethnicity in a multi-ethnic middle-income country with a long-standing history of co-habitation. Stool samples from 214 Malaysian community members (46 Malay, 65 Chinese, 49 Indian, and 54 Jakun) were collected. The gut microbiota of the partici...

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Autores principales:	Jacky Dwiyanto, M. H. Hussain, D. Reidpath, K. S. Ong, A. Qasim, S. W. H. Lee, S. M. Lee, S. C. Foo, C. W. Chong, Sadequr Rahman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b90c60805ec64281a49e14233dafbd24
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spelling	oai:doaj.org-article:b90c60805ec64281a49e14233dafbd242021-12-02T10:47:55ZEthnicity influences the gut microbiota of individuals sharing a geographical location: a cross-sectional study from a middle-income country10.1038/s41598-021-82311-32045-2322https://doaj.org/article/b90c60805ec64281a49e14233dafbd242021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82311-3https://doaj.org/toc/2045-2322Abstract No studies have investigated the influence of ethnicity in a multi-ethnic middle-income country with a long-standing history of co-habitation. Stool samples from 214 Malaysian community members (46 Malay, 65 Chinese, 49 Indian, and 54 Jakun) were collected. The gut microbiota of the participants was investigated using 16S amplicon sequencing. Ethnicity exhibited the largest effect size across participants (PERMANOVA Pseudo-F = 4.24, R2 = 0.06, p = 0.001). Notably, the influence of ethnicity on the gut microbiota was retained even after controlling for all demographic, dietary factors and other covariates which were significantly associated with the gut microbiome (PERMANOVA Pseudo-F = 1.67, R2 = 0.02, p = 0.002). Our result suggested that lifestyle, dietary, and uncharacterized differences collectively drive the gut microbiota variation across ethnicity, making ethnicity a reliable proxy for both identified and unidentified lifestyle and dietary variation across ethnic groups from the same community.Jacky DwiyantoM. H. HussainD. ReidpathK. S. OngA. QasimS. W. H. LeeS. M. LeeS. C. FooC. W. ChongSadequr RahmanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jacky Dwiyanto M. H. Hussain D. Reidpath K. S. Ong A. Qasim S. W. H. Lee S. M. Lee S. C. Foo C. W. Chong Sadequr Rahman Ethnicity influences the gut microbiota of individuals sharing a geographical location: a cross-sectional study from a middle-income country
description	Abstract No studies have investigated the influence of ethnicity in a multi-ethnic middle-income country with a long-standing history of co-habitation. Stool samples from 214 Malaysian community members (46 Malay, 65 Chinese, 49 Indian, and 54 Jakun) were collected. The gut microbiota of the participants was investigated using 16S amplicon sequencing. Ethnicity exhibited the largest effect size across participants (PERMANOVA Pseudo-F = 4.24, R2 = 0.06, p = 0.001). Notably, the influence of ethnicity on the gut microbiota was retained even after controlling for all demographic, dietary factors and other covariates which were significantly associated with the gut microbiome (PERMANOVA Pseudo-F = 1.67, R2 = 0.02, p = 0.002). Our result suggested that lifestyle, dietary, and uncharacterized differences collectively drive the gut microbiota variation across ethnicity, making ethnicity a reliable proxy for both identified and unidentified lifestyle and dietary variation across ethnic groups from the same community.
format	article
author	Jacky Dwiyanto M. H. Hussain D. Reidpath K. S. Ong A. Qasim S. W. H. Lee S. M. Lee S. C. Foo C. W. Chong Sadequr Rahman
author_facet	Jacky Dwiyanto M. H. Hussain D. Reidpath K. S. Ong A. Qasim S. W. H. Lee S. M. Lee S. C. Foo C. W. Chong Sadequr Rahman
author_sort	Jacky Dwiyanto
title	Ethnicity influences the gut microbiota of individuals sharing a geographical location: a cross-sectional study from a middle-income country
title_short	Ethnicity influences the gut microbiota of individuals sharing a geographical location: a cross-sectional study from a middle-income country
title_full	Ethnicity influences the gut microbiota of individuals sharing a geographical location: a cross-sectional study from a middle-income country
title_fullStr	Ethnicity influences the gut microbiota of individuals sharing a geographical location: a cross-sectional study from a middle-income country
title_full_unstemmed	Ethnicity influences the gut microbiota of individuals sharing a geographical location: a cross-sectional study from a middle-income country
title_sort	ethnicity influences the gut microbiota of individuals sharing a geographical location: a cross-sectional study from a middle-income country
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b90c60805ec64281a49e14233dafbd24
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Ethnicity influences the gut microbiota of individuals sharing a geographical location: a cross-sectional study from a middle-income country

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