Curcumin prevents formation of polyglutamine aggregates by inhibiting Vps36, a component of the ESCRT-II complex.

Small molecules with antioxidative properties have been implicated in amyloid disorders. Curcumin is the active ingredient present in turmeric and known for several biological and medicinal effects. Adequate evidence substantiates the importance of curcumin in Alzheimer's disease and recent evi...

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Autores principales:	Meenakshi Verma, Abhishek Sharma, Swarna Naidu, Ankan Kumar Bhadra, Ritushree Kukreti, Vibha Taneja
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b90d63209fc649be9ea259f4be9de01b
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spelling	oai:doaj.org-article:b90d63209fc649be9ea259f4be9de01b2021-11-18T07:09:24ZCurcumin prevents formation of polyglutamine aggregates by inhibiting Vps36, a component of the ESCRT-II complex.1932-620310.1371/journal.pone.0042923https://doaj.org/article/b90d63209fc649be9ea259f4be9de01b2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22880132/?tool=EBIhttps://doaj.org/toc/1932-6203Small molecules with antioxidative properties have been implicated in amyloid disorders. Curcumin is the active ingredient present in turmeric and known for several biological and medicinal effects. Adequate evidence substantiates the importance of curcumin in Alzheimer's disease and recent evidence suggests its role in Prion and Parkinson's disease. However, contradictory effects have been suggested for Huntington's disease. This difference provided a compelling reason to investigate the effect of curcumin on glutamine-rich (Q-rich) and non-glutamine-rich (non Q-rich) amyloid aggregates in the well established yeast model system. Curcumin significantly inhibited the formation of htt72Q-GFP (a Q-rich) and Het-s-GFP (a non Q-rich) aggregates in yeast. We show that curcumin prevents htt72Q-GFP aggregation by down regulating Vps36, a component of the ESCRT-II (Endosomal sorting complex required for transport). Moreover, curcumin disrupted the htt72Q-GFP aggregates that were pre-formed in yeast and cured the yeast prion, [PSI(+)].Meenakshi VermaAbhishek SharmaSwarna NaiduAnkan Kumar BhadraAnkan Kumar BhadraRitushree KukretiVibha TanejaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 8, p e42923 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Meenakshi Verma Abhishek Sharma Swarna Naidu Ankan Kumar Bhadra Ankan Kumar Bhadra Ritushree Kukreti Vibha Taneja Curcumin prevents formation of polyglutamine aggregates by inhibiting Vps36, a component of the ESCRT-II complex.
description	Small molecules with antioxidative properties have been implicated in amyloid disorders. Curcumin is the active ingredient present in turmeric and known for several biological and medicinal effects. Adequate evidence substantiates the importance of curcumin in Alzheimer's disease and recent evidence suggests its role in Prion and Parkinson's disease. However, contradictory effects have been suggested for Huntington's disease. This difference provided a compelling reason to investigate the effect of curcumin on glutamine-rich (Q-rich) and non-glutamine-rich (non Q-rich) amyloid aggregates in the well established yeast model system. Curcumin significantly inhibited the formation of htt72Q-GFP (a Q-rich) and Het-s-GFP (a non Q-rich) aggregates in yeast. We show that curcumin prevents htt72Q-GFP aggregation by down regulating Vps36, a component of the ESCRT-II (Endosomal sorting complex required for transport). Moreover, curcumin disrupted the htt72Q-GFP aggregates that were pre-formed in yeast and cured the yeast prion, [PSI(+)].
format	article
author	Meenakshi Verma Abhishek Sharma Swarna Naidu Ankan Kumar Bhadra Ankan Kumar Bhadra Ritushree Kukreti Vibha Taneja
author_facet	Meenakshi Verma Abhishek Sharma Swarna Naidu Ankan Kumar Bhadra Ankan Kumar Bhadra Ritushree Kukreti Vibha Taneja
author_sort	Meenakshi Verma
title	Curcumin prevents formation of polyglutamine aggregates by inhibiting Vps36, a component of the ESCRT-II complex.
title_short	Curcumin prevents formation of polyglutamine aggregates by inhibiting Vps36, a component of the ESCRT-II complex.
title_full	Curcumin prevents formation of polyglutamine aggregates by inhibiting Vps36, a component of the ESCRT-II complex.
title_fullStr	Curcumin prevents formation of polyglutamine aggregates by inhibiting Vps36, a component of the ESCRT-II complex.
title_full_unstemmed	Curcumin prevents formation of polyglutamine aggregates by inhibiting Vps36, a component of the ESCRT-II complex.
title_sort	curcumin prevents formation of polyglutamine aggregates by inhibiting vps36, a component of the escrt-ii complex.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/b90d63209fc649be9ea259f4be9de01b
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Curcumin prevents formation of polyglutamine aggregates by inhibiting Vps36, a component of the ESCRT-II complex.

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