Nutritional markers and proteome in patients undergoing treatment for pulmonary tuberculosis differ by geographic region.

<h4>Introduction</h4>Contemporary phase 2 TB disease treatment clinical trials have found that microbiologic treatment responses differ between African versus non-African regions, the reasons for which remain unclear. Understanding host and disease phenotypes that may vary by region is i...

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Autores principales:	Leah G Jarsberg, Komal Kedia, Jason Wendler, Aaron T Wright, Paul D Piehowski, Marina A Gritsenko, Tujin Shi, David M Lewinsohn, George B Sigal, Marc H Weiner, Richard D Smith, Joseph Keane, Jon M Jacobs, Payam Nahid
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b9145d89909b47d4854d0bccdbebc6ef
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spelling	oai:doaj.org-article:b9145d89909b47d4854d0bccdbebc6ef2021-12-02T20:05:42ZNutritional markers and proteome in patients undergoing treatment for pulmonary tuberculosis differ by geographic region.1932-620310.1371/journal.pone.0250586https://doaj.org/article/b9145d89909b47d4854d0bccdbebc6ef2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0250586https://doaj.org/toc/1932-6203<h4>Introduction</h4>Contemporary phase 2 TB disease treatment clinical trials have found that microbiologic treatment responses differ between African versus non-African regions, the reasons for which remain unclear. Understanding host and disease phenotypes that may vary by region is important for optimizing curative treatments.<h4>Methods</h4>We characterized clinical features and the serum proteome of phase 2 TB clinical trial participants undergoing treatment for smear positive, culture-confirmed TB, comparing host serum protein expression in clinical trial participants enrolled in African and Non-African regions. Serum samples were collected from 289 participants enrolled in the Centers for Disease Control and Prevention TBTC Study 29 (NCT00694629) at time of enrollment and at the end of the intensive phase (after 40 doses of TB treatment).<h4>Results</h4>After a peptide level proteome analysis utilizing a unique liquid chromatography IM-MS platform (LC-IM-MS) and subsequent statistical analysis, a total of 183 core proteins demonstrated significant differences at both baseline and at week 8 timepoints between participants enrolled from African and non-African regions. The majority of the differentially expressed proteins were upregulated in participants from the African region, and included acute phase proteins, mediators of inflammation, as well as coagulation and complement pathways. Downregulated proteins in the African population were primarily linked to nutritional status and lipid metabolism pathways.<h4>Conclusions</h4>We have identified differentially expressed nutrition and lipid pathway proteins by geographic region in TB patients undergoing treatment for pulmonary tuberculosis, which appear to be associated with differential treatment responses. Future TB clinical trials should collect expanded measures of nutritional status and further evaluate the relationship between nutrition and microbiologic treatment response.Leah G JarsbergKomal KediaJason WendlerAaron T WrightPaul D PiehowskiMarina A GritsenkoTujin ShiDavid M LewinsohnGeorge B SigalMarc H WeinerRichard D SmithJoseph KeaneJon M JacobsPayam NahidPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 5, p e0250586 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Leah G Jarsberg Komal Kedia Jason Wendler Aaron T Wright Paul D Piehowski Marina A Gritsenko Tujin Shi David M Lewinsohn George B Sigal Marc H Weiner Richard D Smith Joseph Keane Jon M Jacobs Payam Nahid Nutritional markers and proteome in patients undergoing treatment for pulmonary tuberculosis differ by geographic region.
description	<h4>Introduction</h4>Contemporary phase 2 TB disease treatment clinical trials have found that microbiologic treatment responses differ between African versus non-African regions, the reasons for which remain unclear. Understanding host and disease phenotypes that may vary by region is important for optimizing curative treatments.<h4>Methods</h4>We characterized clinical features and the serum proteome of phase 2 TB clinical trial participants undergoing treatment for smear positive, culture-confirmed TB, comparing host serum protein expression in clinical trial participants enrolled in African and Non-African regions. Serum samples were collected from 289 participants enrolled in the Centers for Disease Control and Prevention TBTC Study 29 (NCT00694629) at time of enrollment and at the end of the intensive phase (after 40 doses of TB treatment).<h4>Results</h4>After a peptide level proteome analysis utilizing a unique liquid chromatography IM-MS platform (LC-IM-MS) and subsequent statistical analysis, a total of 183 core proteins demonstrated significant differences at both baseline and at week 8 timepoints between participants enrolled from African and non-African regions. The majority of the differentially expressed proteins were upregulated in participants from the African region, and included acute phase proteins, mediators of inflammation, as well as coagulation and complement pathways. Downregulated proteins in the African population were primarily linked to nutritional status and lipid metabolism pathways.<h4>Conclusions</h4>We have identified differentially expressed nutrition and lipid pathway proteins by geographic region in TB patients undergoing treatment for pulmonary tuberculosis, which appear to be associated with differential treatment responses. Future TB clinical trials should collect expanded measures of nutritional status and further evaluate the relationship between nutrition and microbiologic treatment response.
format	article
author	Leah G Jarsberg Komal Kedia Jason Wendler Aaron T Wright Paul D Piehowski Marina A Gritsenko Tujin Shi David M Lewinsohn George B Sigal Marc H Weiner Richard D Smith Joseph Keane Jon M Jacobs Payam Nahid
author_facet	Leah G Jarsberg Komal Kedia Jason Wendler Aaron T Wright Paul D Piehowski Marina A Gritsenko Tujin Shi David M Lewinsohn George B Sigal Marc H Weiner Richard D Smith Joseph Keane Jon M Jacobs Payam Nahid
author_sort	Leah G Jarsberg
title	Nutritional markers and proteome in patients undergoing treatment for pulmonary tuberculosis differ by geographic region.
title_short	Nutritional markers and proteome in patients undergoing treatment for pulmonary tuberculosis differ by geographic region.
title_full	Nutritional markers and proteome in patients undergoing treatment for pulmonary tuberculosis differ by geographic region.
title_fullStr	Nutritional markers and proteome in patients undergoing treatment for pulmonary tuberculosis differ by geographic region.
title_full_unstemmed	Nutritional markers and proteome in patients undergoing treatment for pulmonary tuberculosis differ by geographic region.
title_sort	nutritional markers and proteome in patients undergoing treatment for pulmonary tuberculosis differ by geographic region.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/b9145d89909b47d4854d0bccdbebc6ef
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Nutritional markers and proteome in patients undergoing treatment for pulmonary tuberculosis differ by geographic region.

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