Selective activation of central thalamic fiber pathway facilitates behavioral performance in healthy non-human primates

Abstract Central thalamic deep brain stimulation (CT-DBS) is an investigational therapy to treat enduring cognitive dysfunctions in structurally brain injured (SBI) patients. However, the mechanisms of CT-DBS that promote restoration of cognitive functions are unknown, and the heterogeneous etiology...

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Autores principales:	A. P. Janson, J. L. Baker, I. Sani, K. P. Purpura, N. D. Schiff, C. R. Butson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b916d82157814091bacb1440da840fd0
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spelling	oai:doaj.org-article:b916d82157814091bacb1440da840fd02021-12-05T12:16:02ZSelective activation of central thalamic fiber pathway facilitates behavioral performance in healthy non-human primates10.1038/s41598-021-02270-72045-2322https://doaj.org/article/b916d82157814091bacb1440da840fd02021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02270-7https://doaj.org/toc/2045-2322Abstract Central thalamic deep brain stimulation (CT-DBS) is an investigational therapy to treat enduring cognitive dysfunctions in structurally brain injured (SBI) patients. However, the mechanisms of CT-DBS that promote restoration of cognitive functions are unknown, and the heterogeneous etiology and recovery profiles of SBI patients contribute to variable outcomes when using conventional DBS strategies,which may result in off-target effects due to activation of multiple pathways. To disambiguate the effects of stimulation of two adjacent thalamic pathways, we modeled and experimentally compared conventional and novel ‘field-shaping’ methods of CT-DBS within the central thalamus of healthy non-human primates (NHP) as they performed visuomotor tasks. We show that selective activation of the medial dorsal thalamic tegmental tract (DTTm), but not of the adjacent centromedian-parafascicularis (CM-Pf) pathway, results in robust behavioral facilitation. Our predictive modeling approach in healthy NHPs directly informs ongoing and future clinical investigations of conventional and novel methods of CT-DBS for treating cognitive dysfunctions in SBI patients, for whom no therapy currently exists.A. P. JansonJ. L. BakerI. SaniK. P. PurpuraN. D. SchiffC. R. ButsonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q A. P. Janson J. L. Baker I. Sani K. P. Purpura N. D. Schiff C. R. Butson Selective activation of central thalamic fiber pathway facilitates behavioral performance in healthy non-human primates
description	Abstract Central thalamic deep brain stimulation (CT-DBS) is an investigational therapy to treat enduring cognitive dysfunctions in structurally brain injured (SBI) patients. However, the mechanisms of CT-DBS that promote restoration of cognitive functions are unknown, and the heterogeneous etiology and recovery profiles of SBI patients contribute to variable outcomes when using conventional DBS strategies,which may result in off-target effects due to activation of multiple pathways. To disambiguate the effects of stimulation of two adjacent thalamic pathways, we modeled and experimentally compared conventional and novel ‘field-shaping’ methods of CT-DBS within the central thalamus of healthy non-human primates (NHP) as they performed visuomotor tasks. We show that selective activation of the medial dorsal thalamic tegmental tract (DTTm), but not of the adjacent centromedian-parafascicularis (CM-Pf) pathway, results in robust behavioral facilitation. Our predictive modeling approach in healthy NHPs directly informs ongoing and future clinical investigations of conventional and novel methods of CT-DBS for treating cognitive dysfunctions in SBI patients, for whom no therapy currently exists.
format	article
author	A. P. Janson J. L. Baker I. Sani K. P. Purpura N. D. Schiff C. R. Butson
author_facet	A. P. Janson J. L. Baker I. Sani K. P. Purpura N. D. Schiff C. R. Butson
author_sort	A. P. Janson
title	Selective activation of central thalamic fiber pathway facilitates behavioral performance in healthy non-human primates
title_short	Selective activation of central thalamic fiber pathway facilitates behavioral performance in healthy non-human primates
title_full	Selective activation of central thalamic fiber pathway facilitates behavioral performance in healthy non-human primates
title_fullStr	Selective activation of central thalamic fiber pathway facilitates behavioral performance in healthy non-human primates
title_full_unstemmed	Selective activation of central thalamic fiber pathway facilitates behavioral performance in healthy non-human primates
title_sort	selective activation of central thalamic fiber pathway facilitates behavioral performance in healthy non-human primates
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b916d82157814091bacb1440da840fd0
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Selective activation of central thalamic fiber pathway facilitates behavioral performance in healthy non-human primates

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