Differential associations of ankle and brachial blood pressures with diabetes and cardiovascular diseases: cross-sectional study

Abstract Increased brachial systolic blood-pressure (BP) predicts diabetes (T2DM) but is not fully effective. Value of absolute ankle systolic BP for T2DM compared to brachial systolic BP is not known. Our objectives were to assess independent relationships of ankle-systolic BP with T2DM and cardiov...

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Autores principales:	Hema Viswambharan, Chew Weng Cheng, Kirti Kain
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b916de26048b4635948226f275bfa4ae
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spelling	oai:doaj.org-article:b916de26048b4635948226f275bfa4ae2021-12-02T17:39:32ZDifferential associations of ankle and brachial blood pressures with diabetes and cardiovascular diseases: cross-sectional study10.1038/s41598-021-88973-32045-2322https://doaj.org/article/b916de26048b4635948226f275bfa4ae2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88973-3https://doaj.org/toc/2045-2322Abstract Increased brachial systolic blood-pressure (BP) predicts diabetes (T2DM) but is not fully effective. Value of absolute ankle systolic BP for T2DM compared to brachial systolic BP is not known. Our objectives were to assess independent relationships of ankle-systolic BP with T2DM and cardiovascular disease in Europeans and south Asians. Cross-sectional studies of anonymised data from registered adults (n = 1087) at inner city deprived primary care practices. Study includes 63.85% ethnic minority. Systolic BP of the left and right-brachial, posterior-tibial and dorsalis-pedis-arteries measured using a Doppler probe. Regression models’ factors were age, sex, ethnicity, body mass index (BMI) and waist height ratio (WHtR). Both brachial and ankle systolic-BP increase with diabetes in Europeans and south Asians. We demonstrated that there was a significant positive independent association of ankle BP with diabetes, regardless of age and sex compared to Brachial. There was stronger negative association of ankle blood pressure with cardiovascular disease, after adjustment for BMI, WHtR and ethnicity. Additionally, we found that ankle BP were significantly associated with cardiovascular disease in south Asians more than the Europeans; right posterior tibial. Ankle systolic BPs are superior to brachial BPs to identify risks of Type 2DM and cardiovascular diseases for enhanced patient care.Hema ViswambharanChew Weng ChengKirti KainNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hema Viswambharan Chew Weng Cheng Kirti Kain Differential associations of ankle and brachial blood pressures with diabetes and cardiovascular diseases: cross-sectional study
description	Abstract Increased brachial systolic blood-pressure (BP) predicts diabetes (T2DM) but is not fully effective. Value of absolute ankle systolic BP for T2DM compared to brachial systolic BP is not known. Our objectives were to assess independent relationships of ankle-systolic BP with T2DM and cardiovascular disease in Europeans and south Asians. Cross-sectional studies of anonymised data from registered adults (n = 1087) at inner city deprived primary care practices. Study includes 63.85% ethnic minority. Systolic BP of the left and right-brachial, posterior-tibial and dorsalis-pedis-arteries measured using a Doppler probe. Regression models’ factors were age, sex, ethnicity, body mass index (BMI) and waist height ratio (WHtR). Both brachial and ankle systolic-BP increase with diabetes in Europeans and south Asians. We demonstrated that there was a significant positive independent association of ankle BP with diabetes, regardless of age and sex compared to Brachial. There was stronger negative association of ankle blood pressure with cardiovascular disease, after adjustment for BMI, WHtR and ethnicity. Additionally, we found that ankle BP were significantly associated with cardiovascular disease in south Asians more than the Europeans; right posterior tibial. Ankle systolic BPs are superior to brachial BPs to identify risks of Type 2DM and cardiovascular diseases for enhanced patient care.
format	article
author	Hema Viswambharan Chew Weng Cheng Kirti Kain
author_facet	Hema Viswambharan Chew Weng Cheng Kirti Kain
author_sort	Hema Viswambharan
title	Differential associations of ankle and brachial blood pressures with diabetes and cardiovascular diseases: cross-sectional study
title_short	Differential associations of ankle and brachial blood pressures with diabetes and cardiovascular diseases: cross-sectional study
title_full	Differential associations of ankle and brachial blood pressures with diabetes and cardiovascular diseases: cross-sectional study
title_fullStr	Differential associations of ankle and brachial blood pressures with diabetes and cardiovascular diseases: cross-sectional study
title_full_unstemmed	Differential associations of ankle and brachial blood pressures with diabetes and cardiovascular diseases: cross-sectional study
title_sort	differential associations of ankle and brachial blood pressures with diabetes and cardiovascular diseases: cross-sectional study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b916de26048b4635948226f275bfa4ae
work_keys_str_mv	AT hemaviswambharan differentialassociationsofankleandbrachialbloodpressureswithdiabetesandcardiovasculardiseasescrosssectionalstudy AT chewwengcheng differentialassociationsofankleandbrachialbloodpressureswithdiabetesandcardiovasculardiseasescrosssectionalstudy AT kirtikain differentialassociationsofankleandbrachialbloodpressureswithdiabetesandcardiovasculardiseasescrosssectionalstudy
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Differential associations of ankle and brachial blood pressures with diabetes and cardiovascular diseases: cross-sectional study

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