Relationship Between Helicobacter pylori Infection and Nonalcoholic Fatty Liver Disease (NAFLD) in a Developing Country: A Cross-Sectional Study

Yousry Esam-Eldin Abo-Amer, 1 Aisha Sabal, 2 Rehab Ahmed, 2 Nabil Fathy Esmael Hasan, 3 Rasha Refaie, 4 Sahar Mohamed Mostafa, 2 Ahmed Abdelhaleem Mohamed, 2 Mahmoud Khalil, 2 Waleed Elagawy, 5 Sherief Abd-Elsalam 6 1Hepatology, Gastroenterology and Infectious Diseases Department, Mahala Hepatology...

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Autores principales:	Abo-Amer YEE, Sabal A, Ahmed R, Hasan NFE, Refaie R, Mostafa SM, Mohamed AA, Khalil M, Elagawy W, Abd-Elsalam S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	helicobacter pylori steatosis fibrosis nafld prevalence fibroscan Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/b917b7281c7c497fb27e273957067214
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spelling	oai:doaj.org-article:b917b7281c7c497fb27e2739570672142021-12-02T04:06:11ZRelationship Between Helicobacter pylori Infection and Nonalcoholic Fatty Liver Disease (NAFLD) in a Developing Country: A Cross-Sectional Study1178-7007https://doaj.org/article/b917b7281c7c497fb27e2739570672142020-03-01T00:00:00Zhttps://www.dovepress.com/relationship-between-helicobacter-pylori-infection-and-nonalcoholic-fa-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Yousry Esam-Eldin Abo-Amer, 1 Aisha Sabal, 2 Rehab Ahmed, 2 Nabil Fathy Esmael Hasan, 3 Rasha Refaie, 4 Sahar Mohamed Mostafa, 2 Ahmed Abdelhaleem Mohamed, 2 Mahmoud Khalil, 2 Waleed Elagawy, 5 Sherief Abd-Elsalam 6 1Hepatology, Gastroenterology and Infectious Diseases Department, Mahala Hepatology Teaching Hospital, Gharbia, Egypt; 2Hepatology, Tropical Medicine and Infectious Diseases Departments, National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt; 3Clinical Pathology Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt; 4Internal Medicine Department, Helwan University, Helwan, Egypt; 5Department of Tropical Medicine, Portsaid University, Portsaid, Egypt; 6Tropical Medicine Department, Tanta University, Tanta, EgyptCorrespondence: Sherief Abd-ElsalamTropical Medicine Department, Tanta University, Tanta, EgyptTel +201063319696Email sherif.abdelbaky@med.tanta.edu.egBackground: Non-alcoholic fatty liver disease (NAFLD) is a very common disease that affects 25– 30% of the population in western countries. Many studies have observed the importance of H. pylori infection in the development of insulin resistance, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, and liver fibrosis and cirrhosis. However, the evidence from different studies was controversial. The present study aimed to investigate the relationship between H. pylori infection and NAFLD in a developing country.Patients and Methods: This cross-sectional study included all the attending outpatient clinics at four Major University hospitals and two research and clinical institutes in a developing country in the period between June and October 2019. Patients were assessed for the diagnosis of H. pylori infection as detected by H. pylori antigen in stool; they were also assessed for the diagnosis of NAFLD by ultrasound, fibroscan, and CAP.Results: The study was conducted on 646 patients; H. pylori infection was found to be present in 538 patients (83.3%). NAFLD (diagnosed by both U/S and Fibroscan with CAP), ALT, AST, hepatomegaly, hypertension, fasting blood sugar were significantly higher in H. pylori +ve group than H. pylori −ve group. After performing Linear regression of independent risk factors of NAFLD to prove or to refute the role of Helicobacter; H. pylori positivity, total cholesterol, degree of fatty liver by ultrasound, fasting blood sugar and diastolic blood pressure were independent risk factors for NAFLD.Conclusion: Helicobacter pylori infection was independent risk factors for NAFLD and correlated with increased degree of steatosis.Keywords: Helicobacter pylori, steatosis, fibrosis, NAFLD, prevalence, fibroscanAbo-Amer YEESabal AAhmed RHasan NFERefaie RMostafa SMMohamed AAKhalil MElagawy WAbd-Elsalam SDove Medical Pressarticlehelicobacter pyloristeatosisfibrosisnafldprevalencefibroscanSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 619-625 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	helicobacter pylori steatosis fibrosis nafld prevalence fibroscan Specialties of internal medicine RC581-951
spellingShingle	helicobacter pylori steatosis fibrosis nafld prevalence fibroscan Specialties of internal medicine RC581-951 Abo-Amer YEE Sabal A Ahmed R Hasan NFE Refaie R Mostafa SM Mohamed AA Khalil M Elagawy W Abd-Elsalam S Relationship Between Helicobacter pylori Infection and Nonalcoholic Fatty Liver Disease (NAFLD) in a Developing Country: A Cross-Sectional Study
description	Yousry Esam-Eldin Abo-Amer, 1 Aisha Sabal, 2 Rehab Ahmed, 2 Nabil Fathy Esmael Hasan, 3 Rasha Refaie, 4 Sahar Mohamed Mostafa, 2 Ahmed Abdelhaleem Mohamed, 2 Mahmoud Khalil, 2 Waleed Elagawy, 5 Sherief Abd-Elsalam 6 1Hepatology, Gastroenterology and Infectious Diseases Department, Mahala Hepatology Teaching Hospital, Gharbia, Egypt; 2Hepatology, Tropical Medicine and Infectious Diseases Departments, National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt; 3Clinical Pathology Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt; 4Internal Medicine Department, Helwan University, Helwan, Egypt; 5Department of Tropical Medicine, Portsaid University, Portsaid, Egypt; 6Tropical Medicine Department, Tanta University, Tanta, EgyptCorrespondence: Sherief Abd-ElsalamTropical Medicine Department, Tanta University, Tanta, EgyptTel +201063319696Email sherif.abdelbaky@med.tanta.edu.egBackground: Non-alcoholic fatty liver disease (NAFLD) is a very common disease that affects 25– 30% of the population in western countries. Many studies have observed the importance of H. pylori infection in the development of insulin resistance, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, and liver fibrosis and cirrhosis. However, the evidence from different studies was controversial. The present study aimed to investigate the relationship between H. pylori infection and NAFLD in a developing country.Patients and Methods: This cross-sectional study included all the attending outpatient clinics at four Major University hospitals and two research and clinical institutes in a developing country in the period between June and October 2019. Patients were assessed for the diagnosis of H. pylori infection as detected by H. pylori antigen in stool; they were also assessed for the diagnosis of NAFLD by ultrasound, fibroscan, and CAP.Results: The study was conducted on 646 patients; H. pylori infection was found to be present in 538 patients (83.3%). NAFLD (diagnosed by both U/S and Fibroscan with CAP), ALT, AST, hepatomegaly, hypertension, fasting blood sugar were significantly higher in H. pylori +ve group than H. pylori −ve group. After performing Linear regression of independent risk factors of NAFLD to prove or to refute the role of Helicobacter; H. pylori positivity, total cholesterol, degree of fatty liver by ultrasound, fasting blood sugar and diastolic blood pressure were independent risk factors for NAFLD.Conclusion: Helicobacter pylori infection was independent risk factors for NAFLD and correlated with increased degree of steatosis.Keywords: Helicobacter pylori, steatosis, fibrosis, NAFLD, prevalence, fibroscan
format	article
author	Abo-Amer YEE Sabal A Ahmed R Hasan NFE Refaie R Mostafa SM Mohamed AA Khalil M Elagawy W Abd-Elsalam S
author_facet	Abo-Amer YEE Sabal A Ahmed R Hasan NFE Refaie R Mostafa SM Mohamed AA Khalil M Elagawy W Abd-Elsalam S
author_sort	Abo-Amer YEE
title	Relationship Between Helicobacter pylori Infection and Nonalcoholic Fatty Liver Disease (NAFLD) in a Developing Country: A Cross-Sectional Study
title_short	Relationship Between Helicobacter pylori Infection and Nonalcoholic Fatty Liver Disease (NAFLD) in a Developing Country: A Cross-Sectional Study
title_full	Relationship Between Helicobacter pylori Infection and Nonalcoholic Fatty Liver Disease (NAFLD) in a Developing Country: A Cross-Sectional Study
title_fullStr	Relationship Between Helicobacter pylori Infection and Nonalcoholic Fatty Liver Disease (NAFLD) in a Developing Country: A Cross-Sectional Study
title_full_unstemmed	Relationship Between Helicobacter pylori Infection and Nonalcoholic Fatty Liver Disease (NAFLD) in a Developing Country: A Cross-Sectional Study
title_sort	relationship between helicobacter pylori infection and nonalcoholic fatty liver disease (nafld) in a developing country: a cross-sectional study
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/b917b7281c7c497fb27e273957067214
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Relationship Between Helicobacter pylori Infection and Nonalcoholic Fatty Liver Disease (NAFLD) in a Developing Country: A Cross-Sectional Study

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