Visual impairment increases the risk of dementia, especially in young males in a 12-year longitudinal follow-up study of a national cohort

Abstract We investigated the effect of visual impairment (VI) on dementia development in a national cohort. In this 12-year nationwide population-based retrospective cohort study, national data were collected from National Health Insurance Cooperation of South Korea from 2002 to 2017, comprising 799...

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Autores principales:	Ga-In Lee, Sang Ah Chi, Kyunga Kim, Sang Won Seo, Hee Jin Kim, Tae-Young Chung, Dong Hui Lim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b918258187e44294ac724d81d6002daa
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spelling	oai:doaj.org-article:b918258187e44294ac724d81d6002daa2021-12-02T15:03:14ZVisual impairment increases the risk of dementia, especially in young males in a 12-year longitudinal follow-up study of a national cohort10.1038/s41598-021-91026-42045-2322https://doaj.org/article/b918258187e44294ac724d81d6002daa2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91026-4https://doaj.org/toc/2045-2322Abstract We investigated the effect of visual impairment (VI) on dementia development in a national cohort. In this 12-year nationwide population-based retrospective cohort study, national data were collected from National Health Insurance Cooperation of South Korea from 2002 to 2017, comprising 799,074 subjects selected from the dementia-free cohort representative of the Korean population. Crude hazard ratios (HRs) as well as age- and sex-adjusted HRs and confidence intervals (CIs) for the development of dementia were estimated using multivariable Cox regression models. VI significantly increased the risk of dementia with a HR of 2.726 (95% CI 2.251–3.300, p < 0.0001) after adjusting for age, sex, and interaction between age, sex, and VI. HR of interaction between VI and age for dementia was 0.539 (95% CI 0.436–0.667, p < 0.0001). In the sensitivity analysis after adjustment for age, sex, household income level, BMI and other comorbidities, VI showed higher risk for all the type of dementia (p < 0.0001). In subgroup analysis of VI, young males showed the highest risk for development of dementia with a HR of 2.687 (95% CI 2.219–3.254, p < 0.0001). VI significantly increased the risk of dementia in the study cohort, and young males with VI appeared to be the most susceptible to the development of dementia.Ga-In LeeSang Ah ChiKyunga KimSang Won SeoHee Jin KimTae-Young ChungDong Hui LimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ga-In Lee Sang Ah Chi Kyunga Kim Sang Won Seo Hee Jin Kim Tae-Young Chung Dong Hui Lim Visual impairment increases the risk of dementia, especially in young males in a 12-year longitudinal follow-up study of a national cohort
description	Abstract We investigated the effect of visual impairment (VI) on dementia development in a national cohort. In this 12-year nationwide population-based retrospective cohort study, national data were collected from National Health Insurance Cooperation of South Korea from 2002 to 2017, comprising 799,074 subjects selected from the dementia-free cohort representative of the Korean population. Crude hazard ratios (HRs) as well as age- and sex-adjusted HRs and confidence intervals (CIs) for the development of dementia were estimated using multivariable Cox regression models. VI significantly increased the risk of dementia with a HR of 2.726 (95% CI 2.251–3.300, p < 0.0001) after adjusting for age, sex, and interaction between age, sex, and VI. HR of interaction between VI and age for dementia was 0.539 (95% CI 0.436–0.667, p < 0.0001). In the sensitivity analysis after adjustment for age, sex, household income level, BMI and other comorbidities, VI showed higher risk for all the type of dementia (p < 0.0001). In subgroup analysis of VI, young males showed the highest risk for development of dementia with a HR of 2.687 (95% CI 2.219–3.254, p < 0.0001). VI significantly increased the risk of dementia in the study cohort, and young males with VI appeared to be the most susceptible to the development of dementia.
format	article
author	Ga-In Lee Sang Ah Chi Kyunga Kim Sang Won Seo Hee Jin Kim Tae-Young Chung Dong Hui Lim
author_facet	Ga-In Lee Sang Ah Chi Kyunga Kim Sang Won Seo Hee Jin Kim Tae-Young Chung Dong Hui Lim
author_sort	Ga-In Lee
title	Visual impairment increases the risk of dementia, especially in young males in a 12-year longitudinal follow-up study of a national cohort
title_short	Visual impairment increases the risk of dementia, especially in young males in a 12-year longitudinal follow-up study of a national cohort
title_full	Visual impairment increases the risk of dementia, especially in young males in a 12-year longitudinal follow-up study of a national cohort
title_fullStr	Visual impairment increases the risk of dementia, especially in young males in a 12-year longitudinal follow-up study of a national cohort
title_full_unstemmed	Visual impairment increases the risk of dementia, especially in young males in a 12-year longitudinal follow-up study of a national cohort
title_sort	visual impairment increases the risk of dementia, especially in young males in a 12-year longitudinal follow-up study of a national cohort
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b918258187e44294ac724d81d6002daa
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Visual impairment increases the risk of dementia, especially in young males in a 12-year longitudinal follow-up study of a national cohort

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