Retinopathy of Prematurity and Assisted Reproductive Technology: Is There an Association?

Retinopathy of Prematurity and Assisted Reproductive Technology: Is There an Association?

Alaa Alsammahi, Ahmed Basheikh Department of Ophthalmology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi ArabiaCorrespondence: Alaa AlsammahiDepartment of Ophthalmology, Faculty of Medicine, King Abdulaziz University, P.O. Box 31135, Jeddah 21497, Saudi ArabiaTel +966 590-205-901Ema...

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Autores principales: Alsammahi A, Basheikh A
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2021
Materias:
rop
assisted conception
art
premature
multiple births
gestational age
Ophthalmology
RE1-994
Acceso en línea:https://doaj.org/article/b91af32acbb941f9b518a46eb54d4874
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spelling oai:doaj.org-article:b91af32acbb941f9b518a46eb54d48742021-12-02T15:24:15ZRetinopathy of Prematurity and Assisted Reproductive Technology: Is There an Association?1177-5483https://doaj.org/article/b91af32acbb941f9b518a46eb54d48742021-01-01T00:00:00Zhttps://www.dovepress.com/retinopathy-of-prematurity-and-assisted-reproductive-technology-is-the-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Alaa Alsammahi, Ahmed Basheikh Department of Ophthalmology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi ArabiaCorrespondence: Alaa AlsammahiDepartment of Ophthalmology, Faculty of Medicine, King Abdulaziz University, P.O. Box 31135, Jeddah 21497, Saudi ArabiaTel +966 590-205-901Email samahi779@gmail.comPurpose: This study aimed to determine the incidence of retinopathy of prematurity (ROP) and to assess whether assisted reproductive technology (ART) is a risk factor for ROP independent of the generation of multiple births by determining the occurrence and severity of ROP and the need for treatment. We will also evaluate other risk factors associated with the development of ROP among preterm infants.Patients and Methods: We conducted a retrospective chart review for all premature infants who were screened for ROP according to the screening guidelines of the American Academy of Ophthalmology and born at King Abdulaziz University Hospital from 2015 to 2019. In addition to ophthalmological results, data on gestational age (GA), birth weight (BW), type of pregnancy (singleton or multiple), type of conception (natural or ART), infantile factors, and maternal factors were recorded.Results: A total of 229 preterm babies met our criteria. The mean GA at birth was 29.35 weeks. Notably, 175 neonates were conceived naturally and 54 were conceived by ART. Furthermore, 33 infants in the natural conception group were products of multiple pregnancies, as were 49 infants in the ART group. ROP was noted in 96 of 229 infants (41.92%). No significant difference was found in the occurrence of ROP between multiple neonates in the natural and ART groups. However, ART birth babies in general were significantly associated with the development of ROP (P=0.045). On multiple regression analysis, early GA, low BW, and extended oxygen therapy were the variables most significantly associated with ROP (P≤ 0.001).Conclusion: In our sample, ART in multiple birth babies per se did not seem to be a risk factor for ROP. However, ART babies were more prone to develop ROP than natural conception birth babies, which seemed to be more severe.Keywords: ROP, assisted conception, ART, premature, multiple births, gestational ageAlsammahi ABasheikh ADove Medical Pressarticleropassisted conceptionartprematuremultiple birthsgestational ageOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 15, Pp 227-233 (2021)
institution DOAJ
collection DOAJ
language EN
topic rop
assisted conception
art
premature
multiple births
gestational age
Ophthalmology
RE1-994
spellingShingle rop
assisted conception
art
premature
multiple births
gestational age
Ophthalmology
RE1-994
Alsammahi A
Basheikh A
Retinopathy of Prematurity and Assisted Reproductive Technology: Is There an Association?
description Alaa Alsammahi, Ahmed Basheikh Department of Ophthalmology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi ArabiaCorrespondence: Alaa AlsammahiDepartment of Ophthalmology, Faculty of Medicine, King Abdulaziz University, P.O. Box 31135, Jeddah 21497, Saudi ArabiaTel +966 590-205-901Email samahi779@gmail.comPurpose: This study aimed to determine the incidence of retinopathy of prematurity (ROP) and to assess whether assisted reproductive technology (ART) is a risk factor for ROP independent of the generation of multiple births by determining the occurrence and severity of ROP and the need for treatment. We will also evaluate other risk factors associated with the development of ROP among preterm infants.Patients and Methods: We conducted a retrospective chart review for all premature infants who were screened for ROP according to the screening guidelines of the American Academy of Ophthalmology and born at King Abdulaziz University Hospital from 2015 to 2019. In addition to ophthalmological results, data on gestational age (GA), birth weight (BW), type of pregnancy (singleton or multiple), type of conception (natural or ART), infantile factors, and maternal factors were recorded.Results: A total of 229 preterm babies met our criteria. The mean GA at birth was 29.35 weeks. Notably, 175 neonates were conceived naturally and 54 were conceived by ART. Furthermore, 33 infants in the natural conception group were products of multiple pregnancies, as were 49 infants in the ART group. ROP was noted in 96 of 229 infants (41.92%). No significant difference was found in the occurrence of ROP between multiple neonates in the natural and ART groups. However, ART birth babies in general were significantly associated with the development of ROP (P=0.045). On multiple regression analysis, early GA, low BW, and extended oxygen therapy were the variables most significantly associated with ROP (P≤ 0.001).Conclusion: In our sample, ART in multiple birth babies per se did not seem to be a risk factor for ROP. However, ART babies were more prone to develop ROP than natural conception birth babies, which seemed to be more severe.Keywords: ROP, assisted conception, ART, premature, multiple births, gestational age
format article
author Alsammahi A
Basheikh A
author_facet Alsammahi A
Basheikh A
author_sort Alsammahi A
title Retinopathy of Prematurity and Assisted Reproductive Technology: Is There an Association?
title_short Retinopathy of Prematurity and Assisted Reproductive Technology: Is There an Association?
title_full Retinopathy of Prematurity and Assisted Reproductive Technology: Is There an Association?
title_fullStr Retinopathy of Prematurity and Assisted Reproductive Technology: Is There an Association?
title_full_unstemmed Retinopathy of Prematurity and Assisted Reproductive Technology: Is There an Association?
title_sort retinopathy of prematurity and assisted reproductive technology: is there an association?
publisher Dove Medical Press
publishDate 2021
url https://doaj.org/article/b91af32acbb941f9b518a46eb54d4874
work_keys_str_mv AT alsammahia retinopathyofprematurityandassistedreproductivetechnologyisthereanassociation
AT basheikha retinopathyofprematurityandassistedreproductivetechnologyisthereanassociation
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