Effects of Aerobic Exercise Training on MyomiRs Expression in Cachectic and Non-Cachectic Cancer Mice

We investigated the effects of AET on myomiRs expression in the skeletal muscle and serum of colon cachectic (CT26) and breast non-cachectic (MMTV-PyMT) cancer mice models. Colon cancer decreased microRNA-486 expression, increasing PTEN in tibialis anterior muscle (TA), decreasing the PI3K/mTOR prot...

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Autores principales:	João Lucas Penteado Gomes, Gabriel Cardial Tobias, Tiago Fernandes, André Casanova Silveira, Carlos Eduardo Negrão, Roger Chammas, Patrícia Chakur Brum, Edilamar Menezes Oliveira
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	myomiRs colon cancer breast cancer muscle wasting cancer cachexia CT26 cancer model Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/b91bd9c0df4348d69e2eac248cf24363
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id	oai:doaj.org-article:b91bd9c0df4348d69e2eac248cf24363
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spelling	oai:doaj.org-article:b91bd9c0df4348d69e2eac248cf243632021-11-25T17:03:20ZEffects of Aerobic Exercise Training on MyomiRs Expression in Cachectic and Non-Cachectic Cancer Mice10.3390/cancers132257282072-6694https://doaj.org/article/b91bd9c0df4348d69e2eac248cf243632021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/22/5728https://doaj.org/toc/2072-6694We investigated the effects of AET on myomiRs expression in the skeletal muscle and serum of colon cachectic (CT26) and breast non-cachectic (MMTV-PyMT) cancer mice models. Colon cancer decreased microRNA-486 expression, increasing PTEN in tibialis anterior muscle (TA), decreasing the PI3K/mTOR protein pathway, body and muscle wasting, fibers’ cross-sectional area and muscle dysfunction, that were not preserved by AET. In contrast, breast cancer decreased those muscle functions, but were preserved by AET. In circulation, the downregulation of microRNA-486 and -206 in colon cancer, and the downregulation of microRNA-486 and upregulation of microRNA-206 expression in breast cancer might be good cancer serum biomarkers. Since the microRNA-206 is skeletal muscle specific, their expression was increased in the TA, serum and tumor in MMTV, suggesting a communication among these three compartments. The AET prevents these effects on microRNA-206, but not on microRNA-486 in MMTV. In conclusion, cancer induced a downregulation of microRNA-486 expression in TA and serum of CT26 and MMTV mice and these effects were not prevented by AET; however, to MMTV, the trained muscle function was preserved, probably sustained by the downregulation of microRNA-206 expression. Serum microRNA-206 is a potential biomarker for colon (decreased) and breast (increased) cancer to monitor the disease evolution and the effects promoted by the AET.João Lucas Penteado GomesGabriel Cardial TobiasTiago FernandesAndré Casanova SilveiraCarlos Eduardo NegrãoRoger ChammasPatrícia Chakur BrumEdilamar Menezes OliveiraMDPI AGarticlemyomiRscolon cancerbreast cancermuscle wastingcancer cachexiaCT26 cancer modelNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5728, p 5728 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	myomiRs colon cancer breast cancer muscle wasting cancer cachexia CT26 cancer model Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	myomiRs colon cancer breast cancer muscle wasting cancer cachexia CT26 cancer model Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 João Lucas Penteado Gomes Gabriel Cardial Tobias Tiago Fernandes André Casanova Silveira Carlos Eduardo Negrão Roger Chammas Patrícia Chakur Brum Edilamar Menezes Oliveira Effects of Aerobic Exercise Training on MyomiRs Expression in Cachectic and Non-Cachectic Cancer Mice
description	We investigated the effects of AET on myomiRs expression in the skeletal muscle and serum of colon cachectic (CT26) and breast non-cachectic (MMTV-PyMT) cancer mice models. Colon cancer decreased microRNA-486 expression, increasing PTEN in tibialis anterior muscle (TA), decreasing the PI3K/mTOR protein pathway, body and muscle wasting, fibers’ cross-sectional area and muscle dysfunction, that were not preserved by AET. In contrast, breast cancer decreased those muscle functions, but were preserved by AET. In circulation, the downregulation of microRNA-486 and -206 in colon cancer, and the downregulation of microRNA-486 and upregulation of microRNA-206 expression in breast cancer might be good cancer serum biomarkers. Since the microRNA-206 is skeletal muscle specific, their expression was increased in the TA, serum and tumor in MMTV, suggesting a communication among these three compartments. The AET prevents these effects on microRNA-206, but not on microRNA-486 in MMTV. In conclusion, cancer induced a downregulation of microRNA-486 expression in TA and serum of CT26 and MMTV mice and these effects were not prevented by AET; however, to MMTV, the trained muscle function was preserved, probably sustained by the downregulation of microRNA-206 expression. Serum microRNA-206 is a potential biomarker for colon (decreased) and breast (increased) cancer to monitor the disease evolution and the effects promoted by the AET.
format	article
author	João Lucas Penteado Gomes Gabriel Cardial Tobias Tiago Fernandes André Casanova Silveira Carlos Eduardo Negrão Roger Chammas Patrícia Chakur Brum Edilamar Menezes Oliveira
author_facet	João Lucas Penteado Gomes Gabriel Cardial Tobias Tiago Fernandes André Casanova Silveira Carlos Eduardo Negrão Roger Chammas Patrícia Chakur Brum Edilamar Menezes Oliveira
author_sort	João Lucas Penteado Gomes
title	Effects of Aerobic Exercise Training on MyomiRs Expression in Cachectic and Non-Cachectic Cancer Mice
title_short	Effects of Aerobic Exercise Training on MyomiRs Expression in Cachectic and Non-Cachectic Cancer Mice
title_full	Effects of Aerobic Exercise Training on MyomiRs Expression in Cachectic and Non-Cachectic Cancer Mice
title_fullStr	Effects of Aerobic Exercise Training on MyomiRs Expression in Cachectic and Non-Cachectic Cancer Mice
title_full_unstemmed	Effects of Aerobic Exercise Training on MyomiRs Expression in Cachectic and Non-Cachectic Cancer Mice
title_sort	effects of aerobic exercise training on myomirs expression in cachectic and non-cachectic cancer mice
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b91bd9c0df4348d69e2eac248cf24363
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Effects of Aerobic Exercise Training on MyomiRs Expression in Cachectic and Non-Cachectic Cancer Mice

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