Framework engineering to produce dominant T cell receptors with enhanced antigen-specific function

Framework engineering to produce dominant T cell receptors with enhanced antigen-specific function

Increasing TCR cell surface expression can potentiate T cell responses to low-concentrations of antigen. Here the authors identify aminoacids in human TCR variable domains that impact its surface expression, and demonstrate how editing these residues can improve T cell activation and effector functi...

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Detalles Bibliográficos
Autores principales: Sharyn Thomas, Fiyaz Mohammed, Rogier M. Reijmers, Annemarie Woolston, Theresa Stauss, Alan Kennedy, David Stirling, Angelika Holler, Louisa Green, David Jones, Katherine K. Matthews, David A. Price, Benjamin M. Chain, Mirjam H. M. Heemskerk, Emma C. Morris, Benjamin E. Willcox, Hans J. Stauss
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/b91ffe9fd06f4dd8ae5b0aa7c12c5d8e
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Sumario:Increasing TCR cell surface expression can potentiate T cell responses to low-concentrations of antigen. Here the authors identify aminoacids in human TCR variable domains that impact its surface expression, and demonstrate how editing these residues can improve T cell activation and effector function without altering antigen specificity.

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