Framework engineering to produce dominant T cell receptors with enhanced antigen-specific function

Increasing TCR cell surface expression can potentiate T cell responses to low-concentrations of antigen. Here the authors identify aminoacids in human TCR variable domains that impact its surface expression, and demonstrate how editing these residues can improve T cell activation and effector functi...

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Autores principales:	Sharyn Thomas, Fiyaz Mohammed, Rogier M. Reijmers, Annemarie Woolston, Theresa Stauss, Alan Kennedy, David Stirling, Angelika Holler, Louisa Green, David Jones, Katherine K. Matthews, David A. Price, Benjamin M. Chain, Mirjam H. M. Heemskerk, Emma C. Morris, Benjamin E. Willcox, Hans J. Stauss
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b91ffe9fd06f4dd8ae5b0aa7c12c5d8e
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spelling	oai:doaj.org-article:b91ffe9fd06f4dd8ae5b0aa7c12c5d8e2021-12-02T14:38:39ZFramework engineering to produce dominant T cell receptors with enhanced antigen-specific function10.1038/s41467-019-12441-w2041-1723https://doaj.org/article/b91ffe9fd06f4dd8ae5b0aa7c12c5d8e2019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12441-whttps://doaj.org/toc/2041-1723Increasing TCR cell surface expression can potentiate T cell responses to low-concentrations of antigen. Here the authors identify aminoacids in human TCR variable domains that impact its surface expression, and demonstrate how editing these residues can improve T cell activation and effector function without altering antigen specificity.Sharyn ThomasFiyaz MohammedRogier M. ReijmersAnnemarie WoolstonTheresa StaussAlan KennedyDavid StirlingAngelika HollerLouisa GreenDavid JonesKatherine K. MatthewsDavid A. PriceBenjamin M. ChainMirjam H. M. HeemskerkEmma C. MorrisBenjamin E. WillcoxHans J. StaussNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sharyn Thomas Fiyaz Mohammed Rogier M. Reijmers Annemarie Woolston Theresa Stauss Alan Kennedy David Stirling Angelika Holler Louisa Green David Jones Katherine K. Matthews David A. Price Benjamin M. Chain Mirjam H. M. Heemskerk Emma C. Morris Benjamin E. Willcox Hans J. Stauss Framework engineering to produce dominant T cell receptors with enhanced antigen-specific function
description	Increasing TCR cell surface expression can potentiate T cell responses to low-concentrations of antigen. Here the authors identify aminoacids in human TCR variable domains that impact its surface expression, and demonstrate how editing these residues can improve T cell activation and effector function without altering antigen specificity.
format	article
author	Sharyn Thomas Fiyaz Mohammed Rogier M. Reijmers Annemarie Woolston Theresa Stauss Alan Kennedy David Stirling Angelika Holler Louisa Green David Jones Katherine K. Matthews David A. Price Benjamin M. Chain Mirjam H. M. Heemskerk Emma C. Morris Benjamin E. Willcox Hans J. Stauss
author_facet	Sharyn Thomas Fiyaz Mohammed Rogier M. Reijmers Annemarie Woolston Theresa Stauss Alan Kennedy David Stirling Angelika Holler Louisa Green David Jones Katherine K. Matthews David A. Price Benjamin M. Chain Mirjam H. M. Heemskerk Emma C. Morris Benjamin E. Willcox Hans J. Stauss
author_sort	Sharyn Thomas
title	Framework engineering to produce dominant T cell receptors with enhanced antigen-specific function
title_short	Framework engineering to produce dominant T cell receptors with enhanced antigen-specific function
title_full	Framework engineering to produce dominant T cell receptors with enhanced antigen-specific function
title_fullStr	Framework engineering to produce dominant T cell receptors with enhanced antigen-specific function
title_full_unstemmed	Framework engineering to produce dominant T cell receptors with enhanced antigen-specific function
title_sort	framework engineering to produce dominant t cell receptors with enhanced antigen-specific function
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/b91ffe9fd06f4dd8ae5b0aa7c12c5d8e
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Framework engineering to produce dominant T cell receptors with enhanced antigen-specific function

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