ATR is a multifunctional regulator of male mouse meiosis

ATR kinase is required for meiosis in non-mammalian model organisms. Here the authors demonstrate, using a tissue-specific knockout approach, that ATR is also essential for male meiosis in mouse, regulating meiotic recombination and synapsis.

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Autores principales:	Alexander Widger, Shantha K. Mahadevaiah, Julian Lange, Elias ElInati, Jasmin Zohren, Takayuki Hirota, Sarai Pacheco, Andros Maldonado-Linares, Marcello Stanzione, Obah Ojarikre, Valdone Maciulyte, Dirk G. de Rooij, Attila Tóth, Ignasi Roig, Scott Keeney, James M.A. Turner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b92089ad88aa43c8bc4181f628f431ba
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spelling	oai:doaj.org-article:b92089ad88aa43c8bc4181f628f431ba2021-12-02T14:40:06ZATR is a multifunctional regulator of male mouse meiosis10.1038/s41467-018-04850-02041-1723https://doaj.org/article/b92089ad88aa43c8bc4181f628f431ba2018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04850-0https://doaj.org/toc/2041-1723ATR kinase is required for meiosis in non-mammalian model organisms. Here the authors demonstrate, using a tissue-specific knockout approach, that ATR is also essential for male meiosis in mouse, regulating meiotic recombination and synapsis.Alexander WidgerShantha K. MahadevaiahJulian LangeElias ElInatiJasmin ZohrenTakayuki HirotaSarai PachecoAndros Maldonado-LinaresMarcello StanzioneObah OjarikreValdone MaciulyteDirk G. de RooijAttila TóthIgnasi RoigScott KeeneyJames M.A. TurnerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alexander Widger Shantha K. Mahadevaiah Julian Lange Elias ElInati Jasmin Zohren Takayuki Hirota Sarai Pacheco Andros Maldonado-Linares Marcello Stanzione Obah Ojarikre Valdone Maciulyte Dirk G. de Rooij Attila Tóth Ignasi Roig Scott Keeney James M.A. Turner ATR is a multifunctional regulator of male mouse meiosis
description	ATR kinase is required for meiosis in non-mammalian model organisms. Here the authors demonstrate, using a tissue-specific knockout approach, that ATR is also essential for male meiosis in mouse, regulating meiotic recombination and synapsis.
format	article
author	Alexander Widger Shantha K. Mahadevaiah Julian Lange Elias ElInati Jasmin Zohren Takayuki Hirota Sarai Pacheco Andros Maldonado-Linares Marcello Stanzione Obah Ojarikre Valdone Maciulyte Dirk G. de Rooij Attila Tóth Ignasi Roig Scott Keeney James M.A. Turner
author_facet	Alexander Widger Shantha K. Mahadevaiah Julian Lange Elias ElInati Jasmin Zohren Takayuki Hirota Sarai Pacheco Andros Maldonado-Linares Marcello Stanzione Obah Ojarikre Valdone Maciulyte Dirk G. de Rooij Attila Tóth Ignasi Roig Scott Keeney James M.A. Turner
author_sort	Alexander Widger
title	ATR is a multifunctional regulator of male mouse meiosis
title_short	ATR is a multifunctional regulator of male mouse meiosis
title_full	ATR is a multifunctional regulator of male mouse meiosis
title_fullStr	ATR is a multifunctional regulator of male mouse meiosis
title_full_unstemmed	ATR is a multifunctional regulator of male mouse meiosis
title_sort	atr is a multifunctional regulator of male mouse meiosis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/b92089ad88aa43c8bc4181f628f431ba
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ATR is a multifunctional regulator of male mouse meiosis

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