Impact of hypoxia on the double-strand break repair after photon and carbon ion irradiation of radioresistant HNSCC cells

Impact of hypoxia on the double-strand break repair after photon and carbon ion irradiation of radioresistant HNSCC cells

Abstract DNA double-strand breaks (DSBs) induced by photon irradiation are the most deleterious damage for cancer cells and their efficient repair may contribute to radioresistance, particularly in hypoxic conditions. Carbon ions (C-ions) act independently of the oxygen concentration and trigger com...

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Autores principales: Anne-Sophie Wozny, Gersende Alphonse, Audrey Cassard, Céline Malésys, Safa Louati, Michael Beuve, Philippe Lalle, Dominique Ardail, Tetsuo Nakajima, Claire Rodriguez-Lafrasse
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/b9246a0bfb4742b4a947afac465121a4
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