Thermal Control of Microbial Development and Virulence: Molecular Mechanisms of Microbial Temperature Sensing

ABSTRACT Temperature is a critical and ubiquitous environmental signal that governs the development and virulence of diverse microbial species, including viruses, archaea, bacteria, fungi, and parasites. Microbial survival is contingent upon initiating appropriate responses to the cellular stress in...

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Autores principales:	Rebecca S. Shapiro, Leah E. Cowen
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2012
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/b92d589cffc844638d8db396da4b7ae2
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spelling	oai:doaj.org-article:b92d589cffc844638d8db396da4b7ae22021-11-15T15:39:13ZThermal Control of Microbial Development and Virulence: Molecular Mechanisms of Microbial Temperature Sensing10.1128/mBio.00238-122150-7511https://doaj.org/article/b92d589cffc844638d8db396da4b7ae22012-11-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00238-12https://doaj.org/toc/2150-7511ABSTRACT Temperature is a critical and ubiquitous environmental signal that governs the development and virulence of diverse microbial species, including viruses, archaea, bacteria, fungi, and parasites. Microbial survival is contingent upon initiating appropriate responses to the cellular stress induced by severe environmental temperature change. In the case of microbial pathogens, development and virulence are often coupled to sensing host physiological temperatures. As such, microbes have developed diverse molecular strategies to sense fluctuations in temperature, and nearly all cellular molecules, including proteins, lipids, RNA, and DNA, can act as thermosensors that detect changes in environmental temperature and initiate relevant cellular responses. The myriad of molecular mechanisms by which microbes sense and respond to temperature reveals an elegant repertoire of strategies to orchestrate cellular signaling, developmental programs, and virulence with spatial and temporal environmental cues.Rebecca S. ShapiroLeah E. CowenAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 3, Iss 5 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Rebecca S. Shapiro Leah E. Cowen Thermal Control of Microbial Development and Virulence: Molecular Mechanisms of Microbial Temperature Sensing
description	ABSTRACT Temperature is a critical and ubiquitous environmental signal that governs the development and virulence of diverse microbial species, including viruses, archaea, bacteria, fungi, and parasites. Microbial survival is contingent upon initiating appropriate responses to the cellular stress induced by severe environmental temperature change. In the case of microbial pathogens, development and virulence are often coupled to sensing host physiological temperatures. As such, microbes have developed diverse molecular strategies to sense fluctuations in temperature, and nearly all cellular molecules, including proteins, lipids, RNA, and DNA, can act as thermosensors that detect changes in environmental temperature and initiate relevant cellular responses. The myriad of molecular mechanisms by which microbes sense and respond to temperature reveals an elegant repertoire of strategies to orchestrate cellular signaling, developmental programs, and virulence with spatial and temporal environmental cues.
format	article
author	Rebecca S. Shapiro Leah E. Cowen
author_facet	Rebecca S. Shapiro Leah E. Cowen
author_sort	Rebecca S. Shapiro
title	Thermal Control of Microbial Development and Virulence: Molecular Mechanisms of Microbial Temperature Sensing
title_short	Thermal Control of Microbial Development and Virulence: Molecular Mechanisms of Microbial Temperature Sensing
title_full	Thermal Control of Microbial Development and Virulence: Molecular Mechanisms of Microbial Temperature Sensing
title_fullStr	Thermal Control of Microbial Development and Virulence: Molecular Mechanisms of Microbial Temperature Sensing
title_full_unstemmed	Thermal Control of Microbial Development and Virulence: Molecular Mechanisms of Microbial Temperature Sensing
title_sort	thermal control of microbial development and virulence: molecular mechanisms of microbial temperature sensing
publisher	American Society for Microbiology
publishDate	2012
url	https://doaj.org/article/b92d589cffc844638d8db396da4b7ae2
work_keys_str_mv	AT rebeccasshapiro thermalcontrolofmicrobialdevelopmentandvirulencemolecularmechanismsofmicrobialtemperaturesensing AT leahecowen thermalcontrolofmicrobialdevelopmentandvirulencemolecularmechanismsofmicrobialtemperaturesensing
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Thermal Control of Microbial Development and Virulence: Molecular Mechanisms of Microbial Temperature Sensing

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