Serum soluble (pro)renin receptor level as a prognostic factor in patients undergoing maintenance hemodialysis

Abstract The (pro)renin receptor [(P)RR)] is a multifunctional protein that is cleaved to generate the soluble (P)RR [s(P)RR], reflecting the status of the tissue renin-angiotensin system and/or activity of the (P)RR. The serum s(P)RR level is associated with arteriosclerosis, independent of other r...

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Autores principales:	Yoshifumi Amari, Satoshi Morimoto, Chikahito Suda, Takeshi Iida, Hidenobu Okuda, Takatomi Yurugi, Yasuo Oyama, Naoki Aoyama, Fumitaka Nakajima, Atsuhiro Ichihara
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b93720b3eebc4b56977aa7d6cd58fae0
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spelling	oai:doaj.org-article:b93720b3eebc4b56977aa7d6cd58fae02021-12-02T16:38:49ZSerum soluble (pro)renin receptor level as a prognostic factor in patients undergoing maintenance hemodialysis10.1038/s41598-021-96892-62045-2322https://doaj.org/article/b93720b3eebc4b56977aa7d6cd58fae02021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96892-6https://doaj.org/toc/2045-2322Abstract The (pro)renin receptor [(P)RR)] is a multifunctional protein that is cleaved to generate the soluble (P)RR [s(P)RR], reflecting the status of the tissue renin-angiotensin system and/or activity of the (P)RR. The serum s(P)RR level is associated with arteriosclerosis, independent of other risk factors, in patients undergoing hemodialysis (HD). This study was conducted to investigate whether the s(P)RR level was associated with new-onset cardiovascular events or malignant diseases and poor prognosis in patients undergoing HD. Overall, 258 patients [70 (61–76) years, 146 males] undergoing maintenance HD were prospectively followed up for 60 months. We investigated the relationships between s(P)RR levels and new-onset cardiovascular events/ malignant diseases and mortality during the follow-up period using Cox proportional hazard analyses. The cumulative incidence of new-onset cardiovascular events (P = 0.009) and deaths (P < 0.001), but not of malignant diseases, was significantly greater in patients with higher serum s(P)RR level (≥ 29.8 ng/ml) than in those with lower s(P)RR level (< 29.8 ng/ml). A high serum s(P)RR level was independently correlated with cardiovascular mortality (95% CI 1.001–1.083, P = 0.046). The serum s(P)RR level was associated with cardiovascular events and mortality, thus qualifying as a biomarker for identifying patients requiring intensive care.Yoshifumi AmariSatoshi MorimotoChikahito SudaTakeshi IidaHidenobu OkudaTakatomi YurugiYasuo OyamaNaoki AoyamaFumitaka NakajimaAtsuhiro IchiharaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yoshifumi Amari Satoshi Morimoto Chikahito Suda Takeshi Iida Hidenobu Okuda Takatomi Yurugi Yasuo Oyama Naoki Aoyama Fumitaka Nakajima Atsuhiro Ichihara Serum soluble (pro)renin receptor level as a prognostic factor in patients undergoing maintenance hemodialysis
description	Abstract The (pro)renin receptor [(P)RR)] is a multifunctional protein that is cleaved to generate the soluble (P)RR [s(P)RR], reflecting the status of the tissue renin-angiotensin system and/or activity of the (P)RR. The serum s(P)RR level is associated with arteriosclerosis, independent of other risk factors, in patients undergoing hemodialysis (HD). This study was conducted to investigate whether the s(P)RR level was associated with new-onset cardiovascular events or malignant diseases and poor prognosis in patients undergoing HD. Overall, 258 patients [70 (61–76) years, 146 males] undergoing maintenance HD were prospectively followed up for 60 months. We investigated the relationships between s(P)RR levels and new-onset cardiovascular events/ malignant diseases and mortality during the follow-up period using Cox proportional hazard analyses. The cumulative incidence of new-onset cardiovascular events (P = 0.009) and deaths (P < 0.001), but not of malignant diseases, was significantly greater in patients with higher serum s(P)RR level (≥ 29.8 ng/ml) than in those with lower s(P)RR level (< 29.8 ng/ml). A high serum s(P)RR level was independently correlated with cardiovascular mortality (95% CI 1.001–1.083, P = 0.046). The serum s(P)RR level was associated with cardiovascular events and mortality, thus qualifying as a biomarker for identifying patients requiring intensive care.
format	article
author	Yoshifumi Amari Satoshi Morimoto Chikahito Suda Takeshi Iida Hidenobu Okuda Takatomi Yurugi Yasuo Oyama Naoki Aoyama Fumitaka Nakajima Atsuhiro Ichihara
author_facet	Yoshifumi Amari Satoshi Morimoto Chikahito Suda Takeshi Iida Hidenobu Okuda Takatomi Yurugi Yasuo Oyama Naoki Aoyama Fumitaka Nakajima Atsuhiro Ichihara
author_sort	Yoshifumi Amari
title	Serum soluble (pro)renin receptor level as a prognostic factor in patients undergoing maintenance hemodialysis
title_short	Serum soluble (pro)renin receptor level as a prognostic factor in patients undergoing maintenance hemodialysis
title_full	Serum soluble (pro)renin receptor level as a prognostic factor in patients undergoing maintenance hemodialysis
title_fullStr	Serum soluble (pro)renin receptor level as a prognostic factor in patients undergoing maintenance hemodialysis
title_full_unstemmed	Serum soluble (pro)renin receptor level as a prognostic factor in patients undergoing maintenance hemodialysis
title_sort	serum soluble (pro)renin receptor level as a prognostic factor in patients undergoing maintenance hemodialysis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b93720b3eebc4b56977aa7d6cd58fae0
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Serum soluble (pro)renin receptor level as a prognostic factor in patients undergoing maintenance hemodialysis

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