Host mobility drives pathogen competition in spatially structured populations.

Interactions among multiple infectious agents are increasingly recognized as a fundamental issue in the understanding of key questions in public health regarding pathogen emergence, maintenance, and evolution. The full description of host-multipathogen systems is, however, challenged by the multipli...

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Autores principales:	Chiara Poletto, Sandro Meloni, Vittoria Colizza, Yamir Moreno, Alessandro Vespignani
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/b93e79341a1748b4b7e4ab6075ee0257
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spelling	oai:doaj.org-article:b93e79341a1748b4b7e4ab6075ee02572021-11-18T05:53:40ZHost mobility drives pathogen competition in spatially structured populations.1553-734X1553-735810.1371/journal.pcbi.1003169https://doaj.org/article/b93e79341a1748b4b7e4ab6075ee02572013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23966843/?tool=EBIhttps://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358Interactions among multiple infectious agents are increasingly recognized as a fundamental issue in the understanding of key questions in public health regarding pathogen emergence, maintenance, and evolution. The full description of host-multipathogen systems is, however, challenged by the multiplicity of factors affecting the interaction dynamics and the resulting competition that may occur at different scales, from the within-host scale to the spatial structure and mobility of the host population. Here we study the dynamics of two competing pathogens in a structured host population and assess the impact of the mobility pattern of hosts on the pathogen competition. We model the spatial structure of the host population in terms of a metapopulation network and focus on two strains imported locally in the system and having the same transmission potential but different infectious periods. We find different scenarios leading to competitive success of either one of the strain or to the codominance of both strains in the system. The dominance of the strain characterized by the shorter or longer infectious period depends exclusively on the structure of the population and on the the mobility of hosts across patches. The proposed modeling framework allows the integration of other relevant epidemiological, environmental and demographic factors, opening the path to further mathematical and computational studies of the dynamics of multipathogen systems.Chiara PolettoSandro MeloniVittoria ColizzaYamir MorenoAlessandro VespignaniPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 9, Iss 8, p e1003169 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Chiara Poletto Sandro Meloni Vittoria Colizza Yamir Moreno Alessandro Vespignani Host mobility drives pathogen competition in spatially structured populations.
description	Interactions among multiple infectious agents are increasingly recognized as a fundamental issue in the understanding of key questions in public health regarding pathogen emergence, maintenance, and evolution. The full description of host-multipathogen systems is, however, challenged by the multiplicity of factors affecting the interaction dynamics and the resulting competition that may occur at different scales, from the within-host scale to the spatial structure and mobility of the host population. Here we study the dynamics of two competing pathogens in a structured host population and assess the impact of the mobility pattern of hosts on the pathogen competition. We model the spatial structure of the host population in terms of a metapopulation network and focus on two strains imported locally in the system and having the same transmission potential but different infectious periods. We find different scenarios leading to competitive success of either one of the strain or to the codominance of both strains in the system. The dominance of the strain characterized by the shorter or longer infectious period depends exclusively on the structure of the population and on the the mobility of hosts across patches. The proposed modeling framework allows the integration of other relevant epidemiological, environmental and demographic factors, opening the path to further mathematical and computational studies of the dynamics of multipathogen systems.
format	article
author	Chiara Poletto Sandro Meloni Vittoria Colizza Yamir Moreno Alessandro Vespignani
author_facet	Chiara Poletto Sandro Meloni Vittoria Colizza Yamir Moreno Alessandro Vespignani
author_sort	Chiara Poletto
title	Host mobility drives pathogen competition in spatially structured populations.
title_short	Host mobility drives pathogen competition in spatially structured populations.
title_full	Host mobility drives pathogen competition in spatially structured populations.
title_fullStr	Host mobility drives pathogen competition in spatially structured populations.
title_full_unstemmed	Host mobility drives pathogen competition in spatially structured populations.
title_sort	host mobility drives pathogen competition in spatially structured populations.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/b93e79341a1748b4b7e4ab6075ee0257
work_keys_str_mv	AT chiarapoletto hostmobilitydrivespathogencompetitioninspatiallystructuredpopulations AT sandromeloni hostmobilitydrivespathogencompetitioninspatiallystructuredpopulations AT vittoriacolizza hostmobilitydrivespathogencompetitioninspatiallystructuredpopulations AT yamirmoreno hostmobilitydrivespathogencompetitioninspatiallystructuredpopulations AT alessandrovespignani hostmobilitydrivespathogencompetitioninspatiallystructuredpopulations
_version_	1718424689379901440

Host mobility drives pathogen competition in spatially structured populations.

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