IL-15 and PIM kinases direct the metabolic programming of intestinal intraepithelial lymphocytes

Intraepithelial lymphocytes (IEL) respond to IL-15 complexed with IL-15Ra but how this intrinsically affects IEL is unclear. Here the authors use proteomics analyses of the main mouse IEL subsets and identify PIM kinases as essential for IEL proliferation, metabolism and effector function downstream...

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Autores principales:	Olivia J. James, Maud Vandereyken, Julia M. Marchingo, Francois Singh, Susan E. Bray, Jamie Wilson, Andrew G. Love, Mahima Swamy
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b9423e9bfcec4d6384f2670f756fa2ca
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spelling	oai:doaj.org-article:b9423e9bfcec4d6384f2670f756fa2ca2021-12-02T17:01:21ZIL-15 and PIM kinases direct the metabolic programming of intestinal intraepithelial lymphocytes10.1038/s41467-021-24473-22041-1723https://doaj.org/article/b9423e9bfcec4d6384f2670f756fa2ca2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24473-2https://doaj.org/toc/2041-1723Intraepithelial lymphocytes (IEL) respond to IL-15 complexed with IL-15Ra but how this intrinsically affects IEL is unclear. Here the authors use proteomics analyses of the main mouse IEL subsets and identify PIM kinases as essential for IEL proliferation, metabolism and effector function downstream of IL-15.Olivia J. JamesMaud VandereykenJulia M. MarchingoFrancois SinghSusan E. BrayJamie WilsonAndrew G. LoveMahima SwamyNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Olivia J. James Maud Vandereyken Julia M. Marchingo Francois Singh Susan E. Bray Jamie Wilson Andrew G. Love Mahima Swamy IL-15 and PIM kinases direct the metabolic programming of intestinal intraepithelial lymphocytes
description	Intraepithelial lymphocytes (IEL) respond to IL-15 complexed with IL-15Ra but how this intrinsically affects IEL is unclear. Here the authors use proteomics analyses of the main mouse IEL subsets and identify PIM kinases as essential for IEL proliferation, metabolism and effector function downstream of IL-15.
format	article
author	Olivia J. James Maud Vandereyken Julia M. Marchingo Francois Singh Susan E. Bray Jamie Wilson Andrew G. Love Mahima Swamy
author_facet	Olivia J. James Maud Vandereyken Julia M. Marchingo Francois Singh Susan E. Bray Jamie Wilson Andrew G. Love Mahima Swamy
author_sort	Olivia J. James
title	IL-15 and PIM kinases direct the metabolic programming of intestinal intraepithelial lymphocytes
title_short	IL-15 and PIM kinases direct the metabolic programming of intestinal intraepithelial lymphocytes
title_full	IL-15 and PIM kinases direct the metabolic programming of intestinal intraepithelial lymphocytes
title_fullStr	IL-15 and PIM kinases direct the metabolic programming of intestinal intraepithelial lymphocytes
title_full_unstemmed	IL-15 and PIM kinases direct the metabolic programming of intestinal intraepithelial lymphocytes
title_sort	il-15 and pim kinases direct the metabolic programming of intestinal intraepithelial lymphocytes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b9423e9bfcec4d6384f2670f756fa2ca
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IL-15 and PIM kinases direct the metabolic programming of intestinal intraepithelial lymphocytes

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