2D exfoliated black phosphorus influences healthy and cancer prostate cell behaviors

Abstract Nowadays, prostate cancer is the most widespread tumour in worldwide male population. Actually, brachytherapy is the most advanced radiotherapy strategy for the local treatment of prostate cancer. It consists in the placing of radioactive sources closed to the tumour side thus killing cance...

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Autores principales:	Ines Fasolino, Alessandra Soriente, Maria Caporali, Manuel Serrano-Ruiz, Maurizio Peruzzini, Luigi Ambrosio, Maria Grazia Raucci
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b947b0f8490a407699e060bf87ad2360
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spelling	oai:doaj.org-article:b947b0f8490a407699e060bf87ad23602021-12-02T13:16:19Z2D exfoliated black phosphorus influences healthy and cancer prostate cell behaviors10.1038/s41598-021-85310-62045-2322https://doaj.org/article/b947b0f8490a407699e060bf87ad23602021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85310-6https://doaj.org/toc/2045-2322Abstract Nowadays, prostate cancer is the most widespread tumour in worldwide male population. Actually, brachytherapy is the most advanced radiotherapy strategy for the local treatment of prostate cancer. It consists in the placing of radioactive sources closed to the tumour side thus killing cancer cells. However, brachytherapy causes the same adverse effects of external-beam radiotherapy. Therefore, alternative treatment approaches are required for enhancing radiotherapy effectiveness and reducing toxic symptoms. Nanostructured exfoliated black phosphorus (2D BP) may represent a strategic tool for local cancer therapy because of its capability to induce singlet oxygen production and act as photosensitizer. Hence, we investigated 2D BP in vitro effect on healthy and cancer prostate cell behavior. 2D BP was obtained through liquid exfoliation. 2D BP effect on healthy and cancer prostate cell behaviors was analyzed by investigating cell viability, oxidative stress and inflammatory marker expression. 2D BP inhibited prostate cancer cell survival, meanwhile promoted healthy prostate cell survival in vitro by modulating oxidative stress and immune response with and without near-infrared light (NIR)-irradiation. Nanostructured 2D BP is able to inhibit in vitro prostate cancer cells survival and preserve healthy prostate cell vitality through the control of oxidative stress and immune response, respectively.Ines FasolinoAlessandra SorienteMaria CaporaliManuel Serrano-RuizMaurizio PeruzziniLuigi AmbrosioMaria Grazia RaucciNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ines Fasolino Alessandra Soriente Maria Caporali Manuel Serrano-Ruiz Maurizio Peruzzini Luigi Ambrosio Maria Grazia Raucci 2D exfoliated black phosphorus influences healthy and cancer prostate cell behaviors
description	Abstract Nowadays, prostate cancer is the most widespread tumour in worldwide male population. Actually, brachytherapy is the most advanced radiotherapy strategy for the local treatment of prostate cancer. It consists in the placing of radioactive sources closed to the tumour side thus killing cancer cells. However, brachytherapy causes the same adverse effects of external-beam radiotherapy. Therefore, alternative treatment approaches are required for enhancing radiotherapy effectiveness and reducing toxic symptoms. Nanostructured exfoliated black phosphorus (2D BP) may represent a strategic tool for local cancer therapy because of its capability to induce singlet oxygen production and act as photosensitizer. Hence, we investigated 2D BP in vitro effect on healthy and cancer prostate cell behavior. 2D BP was obtained through liquid exfoliation. 2D BP effect on healthy and cancer prostate cell behaviors was analyzed by investigating cell viability, oxidative stress and inflammatory marker expression. 2D BP inhibited prostate cancer cell survival, meanwhile promoted healthy prostate cell survival in vitro by modulating oxidative stress and immune response with and without near-infrared light (NIR)-irradiation. Nanostructured 2D BP is able to inhibit in vitro prostate cancer cells survival and preserve healthy prostate cell vitality through the control of oxidative stress and immune response, respectively.
format	article
author	Ines Fasolino Alessandra Soriente Maria Caporali Manuel Serrano-Ruiz Maurizio Peruzzini Luigi Ambrosio Maria Grazia Raucci
author_facet	Ines Fasolino Alessandra Soriente Maria Caporali Manuel Serrano-Ruiz Maurizio Peruzzini Luigi Ambrosio Maria Grazia Raucci
author_sort	Ines Fasolino
title	2D exfoliated black phosphorus influences healthy and cancer prostate cell behaviors
title_short	2D exfoliated black phosphorus influences healthy and cancer prostate cell behaviors
title_full	2D exfoliated black phosphorus influences healthy and cancer prostate cell behaviors
title_fullStr	2D exfoliated black phosphorus influences healthy and cancer prostate cell behaviors
title_full_unstemmed	2D exfoliated black phosphorus influences healthy and cancer prostate cell behaviors
title_sort	2d exfoliated black phosphorus influences healthy and cancer prostate cell behaviors
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b947b0f8490a407699e060bf87ad2360
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2D exfoliated black phosphorus influences healthy and cancer prostate cell behaviors

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