Structure–function analysis of oncogenic EGFR Kinase Domain Duplication reveals insights into activation and a potential approach for therapeutic targeting
An EGFR mutant with kinase domain duplication (EGFR-KDD) was previously identified in an index patient, but the functional and therapeutic implications remain unclear. Here, the authors show that KDD occurs in other ErbB receptors in multiple cancers, and characterize the mechanism and inhibition of...
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Nature Portfolio
2021
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oai:doaj.org-article:b948db7f0a2649d5908bbadfe529545e2021-12-02T13:14:53ZStructure–function analysis of oncogenic EGFR Kinase Domain Duplication reveals insights into activation and a potential approach for therapeutic targeting10.1038/s41467-021-21613-62041-1723https://doaj.org/article/b948db7f0a2649d5908bbadfe529545e2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21613-6https://doaj.org/toc/2041-1723An EGFR mutant with kinase domain duplication (EGFR-KDD) was previously identified in an index patient, but the functional and therapeutic implications remain unclear. Here, the authors show that KDD occurs in other ErbB receptors in multiple cancers, and characterize the mechanism and inhibition of EGFR-KDD.Zhenfang DuBenjamin P. BrownSoyeon KimDonna FergusonDean C. PavlickGowtham JayakumaranRyma BenayedJean-Nicolas GallantYun-Kai ZhangYingjun YanMonica Red-BrewerSiraj M. AliAlexa B. SchrockAhmet ZehirMarc LadanyiAdam W. SmithJens MeilerChristine M. LovlyNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Zhenfang Du Benjamin P. Brown Soyeon Kim Donna Ferguson Dean C. Pavlick Gowtham Jayakumaran Ryma Benayed Jean-Nicolas Gallant Yun-Kai Zhang Yingjun Yan Monica Red-Brewer Siraj M. Ali Alexa B. Schrock Ahmet Zehir Marc Ladanyi Adam W. Smith Jens Meiler Christine M. Lovly Structure–function analysis of oncogenic EGFR Kinase Domain Duplication reveals insights into activation and a potential approach for therapeutic targeting |
| description |
An EGFR mutant with kinase domain duplication (EGFR-KDD) was previously identified in an index patient, but the functional and therapeutic implications remain unclear. Here, the authors show that KDD occurs in other ErbB receptors in multiple cancers, and characterize the mechanism and inhibition of EGFR-KDD. |
| format |
article |
| author |
Zhenfang Du Benjamin P. Brown Soyeon Kim Donna Ferguson Dean C. Pavlick Gowtham Jayakumaran Ryma Benayed Jean-Nicolas Gallant Yun-Kai Zhang Yingjun Yan Monica Red-Brewer Siraj M. Ali Alexa B. Schrock Ahmet Zehir Marc Ladanyi Adam W. Smith Jens Meiler Christine M. Lovly |
| author_facet |
Zhenfang Du Benjamin P. Brown Soyeon Kim Donna Ferguson Dean C. Pavlick Gowtham Jayakumaran Ryma Benayed Jean-Nicolas Gallant Yun-Kai Zhang Yingjun Yan Monica Red-Brewer Siraj M. Ali Alexa B. Schrock Ahmet Zehir Marc Ladanyi Adam W. Smith Jens Meiler Christine M. Lovly |
| author_sort |
Zhenfang Du |
| title |
Structure–function analysis of oncogenic EGFR Kinase Domain Duplication reveals insights into activation and a potential approach for therapeutic targeting |
| title_short |
Structure–function analysis of oncogenic EGFR Kinase Domain Duplication reveals insights into activation and a potential approach for therapeutic targeting |
| title_full |
Structure–function analysis of oncogenic EGFR Kinase Domain Duplication reveals insights into activation and a potential approach for therapeutic targeting |
| title_fullStr |
Structure–function analysis of oncogenic EGFR Kinase Domain Duplication reveals insights into activation and a potential approach for therapeutic targeting |
| title_full_unstemmed |
Structure–function analysis of oncogenic EGFR Kinase Domain Duplication reveals insights into activation and a potential approach for therapeutic targeting |
| title_sort |
structure–function analysis of oncogenic egfr kinase domain duplication reveals insights into activation and a potential approach for therapeutic targeting |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/b948db7f0a2649d5908bbadfe529545e |
| work_keys_str_mv |
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