Fine mapping of a region of chromosome 11q23.3 reveals independent locus associated with risk of glioma.

<h4>Background</h4>A single nucleotide polymorphism (SNP) at locus 11q23.3 (rs498872) in the near 5'-UTR of the PHLDB1 gene was recently implicated as a risk factor for gliomas in a genome-wide association study, and this involvement was confirmed in three additional studies.<h4&...

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Autores principales:	Hongyan Chen, Bing Sun, Yingjie Zhao, Xiao Song, Weiwei Fan, Keke Zhou, Liangfu Zhou, Ying Mao, Daru Lu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b94cf20a35f04a0ab25f7b6bee45f4e5
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spelling	oai:doaj.org-article:b94cf20a35f04a0ab25f7b6bee45f4e52021-11-18T08:03:06ZFine mapping of a region of chromosome 11q23.3 reveals independent locus associated with risk of glioma.1932-620310.1371/journal.pone.0052864https://doaj.org/article/b94cf20a35f04a0ab25f7b6bee45f4e52012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23300798/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>A single nucleotide polymorphism (SNP) at locus 11q23.3 (rs498872) in the near 5'-UTR of the PHLDB1 gene was recently implicated as a risk factor for gliomas in a genome-wide association study, and this involvement was confirmed in three additional studies.<h4>Methodology/principal findings</h4>To identify possible causal variants in the region, the authors genotyped 15 tagging SNPs in the 200 kb genomic region at 11q23.3 locus in a Chinese Han population-based case-control study with 983 cases and 1024 controls. We found evidence for an association between two independent loci (both the PHLDB1 and the ACRN1 genes) and a predisposition for gliomas. Among the multiple significant SNPs in the PHLDB1 gene region, the rs17749 SNP was the most significant [P = 1.31×10⁻⁶ in a recessive genetic model]. Additionally, two novel SNPs (rs2236661 and rs494560) that were independent of rs17749 were significantly associated with glioma risk in a recessive genetic model [P = 1.31×10⁻⁵ and P = 3.32×10⁻⁵, respectively]. The second novel locus was within the ARCN1 gene, and it was associated with a significantly reduced risk for glioma.<h4>Conclusions/significance</h4>Our data strongly support PHLDB1 as a susceptibility gene for glioma, also shedding light on a new potentially candidate gene, ARCN1.Hongyan ChenBing SunYingjie ZhaoXiao SongWeiwei FanKeke ZhouLiangfu ZhouYing MaoDaru LuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 12, p e52864 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hongyan Chen Bing Sun Yingjie Zhao Xiao Song Weiwei Fan Keke Zhou Liangfu Zhou Ying Mao Daru Lu Fine mapping of a region of chromosome 11q23.3 reveals independent locus associated with risk of glioma.
description	<h4>Background</h4>A single nucleotide polymorphism (SNP) at locus 11q23.3 (rs498872) in the near 5'-UTR of the PHLDB1 gene was recently implicated as a risk factor for gliomas in a genome-wide association study, and this involvement was confirmed in three additional studies.<h4>Methodology/principal findings</h4>To identify possible causal variants in the region, the authors genotyped 15 tagging SNPs in the 200 kb genomic region at 11q23.3 locus in a Chinese Han population-based case-control study with 983 cases and 1024 controls. We found evidence for an association between two independent loci (both the PHLDB1 and the ACRN1 genes) and a predisposition for gliomas. Among the multiple significant SNPs in the PHLDB1 gene region, the rs17749 SNP was the most significant [P = 1.31×10⁻⁶ in a recessive genetic model]. Additionally, two novel SNPs (rs2236661 and rs494560) that were independent of rs17749 were significantly associated with glioma risk in a recessive genetic model [P = 1.31×10⁻⁵ and P = 3.32×10⁻⁵, respectively]. The second novel locus was within the ARCN1 gene, and it was associated with a significantly reduced risk for glioma.<h4>Conclusions/significance</h4>Our data strongly support PHLDB1 as a susceptibility gene for glioma, also shedding light on a new potentially candidate gene, ARCN1.
format	article
author	Hongyan Chen Bing Sun Yingjie Zhao Xiao Song Weiwei Fan Keke Zhou Liangfu Zhou Ying Mao Daru Lu
author_facet	Hongyan Chen Bing Sun Yingjie Zhao Xiao Song Weiwei Fan Keke Zhou Liangfu Zhou Ying Mao Daru Lu
author_sort	Hongyan Chen
title	Fine mapping of a region of chromosome 11q23.3 reveals independent locus associated with risk of glioma.
title_short	Fine mapping of a region of chromosome 11q23.3 reveals independent locus associated with risk of glioma.
title_full	Fine mapping of a region of chromosome 11q23.3 reveals independent locus associated with risk of glioma.
title_fullStr	Fine mapping of a region of chromosome 11q23.3 reveals independent locus associated with risk of glioma.
title_full_unstemmed	Fine mapping of a region of chromosome 11q23.3 reveals independent locus associated with risk of glioma.
title_sort	fine mapping of a region of chromosome 11q23.3 reveals independent locus associated with risk of glioma.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/b94cf20a35f04a0ab25f7b6bee45f4e5
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Fine mapping of a region of chromosome 11q23.3 reveals independent locus associated with risk of glioma.

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