Central retinal vein occlusion and pseudoexfoliation syndrome

Dimitrios Karagiannis,1 Georgios A Kontadakis,1,2 Nektarios E Klados,2 Ioannis Tsoumpris,1 Artemios S Kandarakis,1 Efstratios A Parikakis,1 Ilias Georgalas,3 Miltiadis K Tsilimbaris21Ophthalmiatreio Eye Hospital of Athens, Athens, Greece; 2Department of Ophthalmology, University Hospital of Heraklio...

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Autores principales: Karagiannis D, Kontadakis GA, Klados N, Tsoumpris I, Kandarakis AS, Parikakis EA, Georgalas I, Tsilimbaris MK
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Publicado: Dove Medical Press 2015
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spelling oai:doaj.org-article:b94d0a0fe5af45a097cbee2b8ad60d072021-12-02T04:43:56ZCentral retinal vein occlusion and pseudoexfoliation syndrome1178-1998https://doaj.org/article/b94d0a0fe5af45a097cbee2b8ad60d072015-05-01T00:00:00Zhttps://www.dovepress.com/central-retinal-vein-occlusion-and-pseudoexfoliation-syndrome-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Dimitrios Karagiannis,1 Georgios A Kontadakis,1,2 Nektarios E Klados,2 Ioannis Tsoumpris,1 Artemios S Kandarakis,1 Efstratios A Parikakis,1 Ilias Georgalas,3 Miltiadis K Tsilimbaris21Ophthalmiatreio Eye Hospital of Athens, Athens, Greece; 2Department of Ophthalmology, University Hospital of Heraklion, University of Crete, Heraklion, Greece; 3Department of Ophthalmology, General Hospital of Athens, Athens, Greece Purpose: The purpose of this study was to investigate the existence of pseudoexfoliation syndrome (PXF) as a risk factor for the development of central retinal vein occlusion (CRVO).Methods: This was a retrospective, comparative study of the prevalence of pseudoexfoliation in three groups of patients: 48 patients with CRVO, 164 patients with branch retinal vein occlusion (BRVO), and 70 control patients (70 eyes). All patients were phakic and had no previous diagnosis of glaucoma. Patients were matched in terms of age and systemic hypertension. All patients had normal intraocular pressure (IOP) at presentation (defined as less than or equal to 21 mmHg).Results: In the CRVO group, 14 out of 48 patients were diagnosed as having PXF (29.17%). In the BRVO group, 14 out of 164 patients had PXF (8.5%), and in the control group, six out of 70 patients had PXF (8.6%). Differences of percentage between groups were statistically significant (P<0.001, χ2 test). When comparing patient subgroup with ischemic CRVO with subgroup with non-ischemic CRVO, we found that in the ischemic CRVO group, 13 out of 27 patients were diagnosed as having PXF (48.15%), and in the non-ischemic CRVO group, one out of 21 patients was diagnosed as having PXF (4.7%; P<0.001, χ2 test). The relative odds of having CRVO in patients with PXF versus patients without PXF were 4.406 (confidence interval [CI], 2.03–9.54).Conclusion: PXF and CRVO, especially ischemic, are strongly associated in our study. Our results indicate that PXF might be an independent factor for CRVO, as it is related with CRVO independently from glaucoma.Keywords: pseudoexfoliation, ischemic and non-ischemic central retinal vein occlusion, branch retinal vein occlusion, glaucomaKaragiannis DKontadakis GAKlados NTsoumpris IKandarakis ASParikakis EAGeorgalas ITsilimbaris MKDove Medical PressarticlePseudoexfoliationischemic and non ischemic central retinal vein occlusionbranch retinal vein occlusionglaucomaGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 10, Pp 879-883 (2015)
institution DOAJ
collection DOAJ
language EN
topic Pseudoexfoliation
ischemic and non ischemic central retinal vein occlusion
branch retinal vein occlusion
glaucoma
Geriatrics
RC952-954.6
spellingShingle Pseudoexfoliation
ischemic and non ischemic central retinal vein occlusion
branch retinal vein occlusion
glaucoma
Geriatrics
RC952-954.6
Karagiannis D
Kontadakis GA
Klados N
Tsoumpris I
Kandarakis AS
Parikakis EA
Georgalas I
Tsilimbaris MK
Central retinal vein occlusion and pseudoexfoliation syndrome
description Dimitrios Karagiannis,1 Georgios A Kontadakis,1,2 Nektarios E Klados,2 Ioannis Tsoumpris,1 Artemios S Kandarakis,1 Efstratios A Parikakis,1 Ilias Georgalas,3 Miltiadis K Tsilimbaris21Ophthalmiatreio Eye Hospital of Athens, Athens, Greece; 2Department of Ophthalmology, University Hospital of Heraklion, University of Crete, Heraklion, Greece; 3Department of Ophthalmology, General Hospital of Athens, Athens, Greece Purpose: The purpose of this study was to investigate the existence of pseudoexfoliation syndrome (PXF) as a risk factor for the development of central retinal vein occlusion (CRVO).Methods: This was a retrospective, comparative study of the prevalence of pseudoexfoliation in three groups of patients: 48 patients with CRVO, 164 patients with branch retinal vein occlusion (BRVO), and 70 control patients (70 eyes). All patients were phakic and had no previous diagnosis of glaucoma. Patients were matched in terms of age and systemic hypertension. All patients had normal intraocular pressure (IOP) at presentation (defined as less than or equal to 21 mmHg).Results: In the CRVO group, 14 out of 48 patients were diagnosed as having PXF (29.17%). In the BRVO group, 14 out of 164 patients had PXF (8.5%), and in the control group, six out of 70 patients had PXF (8.6%). Differences of percentage between groups were statistically significant (P<0.001, χ2 test). When comparing patient subgroup with ischemic CRVO with subgroup with non-ischemic CRVO, we found that in the ischemic CRVO group, 13 out of 27 patients were diagnosed as having PXF (48.15%), and in the non-ischemic CRVO group, one out of 21 patients was diagnosed as having PXF (4.7%; P<0.001, χ2 test). The relative odds of having CRVO in patients with PXF versus patients without PXF were 4.406 (confidence interval [CI], 2.03–9.54).Conclusion: PXF and CRVO, especially ischemic, are strongly associated in our study. Our results indicate that PXF might be an independent factor for CRVO, as it is related with CRVO independently from glaucoma.Keywords: pseudoexfoliation, ischemic and non-ischemic central retinal vein occlusion, branch retinal vein occlusion, glaucoma
format article
author Karagiannis D
Kontadakis GA
Klados N
Tsoumpris I
Kandarakis AS
Parikakis EA
Georgalas I
Tsilimbaris MK
author_facet Karagiannis D
Kontadakis GA
Klados N
Tsoumpris I
Kandarakis AS
Parikakis EA
Georgalas I
Tsilimbaris MK
author_sort Karagiannis D
title Central retinal vein occlusion and pseudoexfoliation syndrome
title_short Central retinal vein occlusion and pseudoexfoliation syndrome
title_full Central retinal vein occlusion and pseudoexfoliation syndrome
title_fullStr Central retinal vein occlusion and pseudoexfoliation syndrome
title_full_unstemmed Central retinal vein occlusion and pseudoexfoliation syndrome
title_sort central retinal vein occlusion and pseudoexfoliation syndrome
publisher Dove Medical Press
publishDate 2015
url https://doaj.org/article/b94d0a0fe5af45a097cbee2b8ad60d07
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