Human-Specific Bacterial Pore-Forming Toxins Induce Programmed Necrosis in Erythrocytes

Human-Specific Bacterial Pore-Forming Toxins Induce Programmed Necrosis in Erythrocytes

ABSTRACT A subgroup of the cholesterol-dependent cytolysin (CDC) family of pore-forming toxins (PFTs) has an unusually narrow host range due to a requirement for binding to human CD59 (hCD59), a glycosylphosphatidylinositol (GPI)-linked complement regulatory molecule. hCD59-specific CDCs are produce...

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Autores principales: Timothy J. LaRocca, Elizabeth A. Stivison, Eldad A. Hod, Steven L. Spitalnik, Peter J. Cowan, Tara M. Randis, Adam J. Ratner
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2014
Materias:
Microbiology
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Acceso en línea:https://doaj.org/article/b94d52502cd64185b0f9e850e20d7be5
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