Calcium input frequency, duration and amplitude differentially modulate the relative activation of calcineurin and CaMKII.

NMDA receptor dependent long-term potentiation (LTP) and long-term depression (LTD) are two prominent forms of synaptic plasticity, both of which are triggered by post-synaptic calcium elevation. To understand how calcium selectively stimulates two opposing processes, we developed a detailed computa...

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Autores principales: Lu Li, Melanie I Stefan, Nicolas Le Novère
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
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Acceso en línea:https://doaj.org/article/b94ee3fd9f65432d89bc6892ce023c70
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