Large field of view, fast and low dose multimodal phase-contrast imaging at high x-ray energy

Abstract X-ray phase contrast imaging (XPCI) is an innovative imaging technique which extends the contrast capabilities of ‘conventional’ absorption based x-ray systems. However, so far all XPCI implementations have suffered from one or more of the following limitations: low x-ray energies, small fi...

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Autores principales:	Alberto Astolfo, Marco Endrizzi, Fabio A. Vittoria, Paul C. Diemoz, Benjamin Price, Ian Haig, Alessandro Olivo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b9526e3608f24416b4fc0e054678139d
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spelling	oai:doaj.org-article:b9526e3608f24416b4fc0e054678139d2021-12-02T12:31:58ZLarge field of view, fast and low dose multimodal phase-contrast imaging at high x-ray energy10.1038/s41598-017-02412-w2045-2322https://doaj.org/article/b9526e3608f24416b4fc0e054678139d2017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02412-whttps://doaj.org/toc/2045-2322Abstract X-ray phase contrast imaging (XPCI) is an innovative imaging technique which extends the contrast capabilities of ‘conventional’ absorption based x-ray systems. However, so far all XPCI implementations have suffered from one or more of the following limitations: low x-ray energies, small field of view (FOV) and long acquisition times. Those limitations relegated XPCI to a ‘research-only’ technique with an uncertain future in terms of large scale, high impact applications. We recently succeeded in designing, realizing and testing an XPCI system, which achieves significant steps toward simultaneously overcoming these limitations. Our system combines, for the first time, large FOV, high energy and fast scanning. Importantly, it is capable of providing high image quality at low x-ray doses, compatible with or even below those currently used in medical imaging. This extends the use of XPCI to areas which were unpractical or even inaccessible to previous XPCI solutions. We expect this will enable a long overdue translation into application fields such as security screening, industrial inspections and large FOV medical radiography – all with the inherent advantages of the XPCI multimodality.Alberto AstolfoMarco EndrizziFabio A. VittoriaPaul C. DiemozBenjamin PriceIan HaigAlessandro OlivoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alberto Astolfo Marco Endrizzi Fabio A. Vittoria Paul C. Diemoz Benjamin Price Ian Haig Alessandro Olivo Large field of view, fast and low dose multimodal phase-contrast imaging at high x-ray energy
description	Abstract X-ray phase contrast imaging (XPCI) is an innovative imaging technique which extends the contrast capabilities of ‘conventional’ absorption based x-ray systems. However, so far all XPCI implementations have suffered from one or more of the following limitations: low x-ray energies, small field of view (FOV) and long acquisition times. Those limitations relegated XPCI to a ‘research-only’ technique with an uncertain future in terms of large scale, high impact applications. We recently succeeded in designing, realizing and testing an XPCI system, which achieves significant steps toward simultaneously overcoming these limitations. Our system combines, for the first time, large FOV, high energy and fast scanning. Importantly, it is capable of providing high image quality at low x-ray doses, compatible with or even below those currently used in medical imaging. This extends the use of XPCI to areas which were unpractical or even inaccessible to previous XPCI solutions. We expect this will enable a long overdue translation into application fields such as security screening, industrial inspections and large FOV medical radiography – all with the inherent advantages of the XPCI multimodality.
format	article
author	Alberto Astolfo Marco Endrizzi Fabio A. Vittoria Paul C. Diemoz Benjamin Price Ian Haig Alessandro Olivo
author_facet	Alberto Astolfo Marco Endrizzi Fabio A. Vittoria Paul C. Diemoz Benjamin Price Ian Haig Alessandro Olivo
author_sort	Alberto Astolfo
title	Large field of view, fast and low dose multimodal phase-contrast imaging at high x-ray energy
title_short	Large field of view, fast and low dose multimodal phase-contrast imaging at high x-ray energy
title_full	Large field of view, fast and low dose multimodal phase-contrast imaging at high x-ray energy
title_fullStr	Large field of view, fast and low dose multimodal phase-contrast imaging at high x-ray energy
title_full_unstemmed	Large field of view, fast and low dose multimodal phase-contrast imaging at high x-ray energy
title_sort	large field of view, fast and low dose multimodal phase-contrast imaging at high x-ray energy
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b9526e3608f24416b4fc0e054678139d
work_keys_str_mv	AT albertoastolfo largefieldofviewfastandlowdosemultimodalphasecontrastimagingathighxrayenergy AT marcoendrizzi largefieldofviewfastandlowdosemultimodalphasecontrastimagingathighxrayenergy AT fabioavittoria largefieldofviewfastandlowdosemultimodalphasecontrastimagingathighxrayenergy AT paulcdiemoz largefieldofviewfastandlowdosemultimodalphasecontrastimagingathighxrayenergy AT benjaminprice largefieldofviewfastandlowdosemultimodalphasecontrastimagingathighxrayenergy AT ianhaig largefieldofviewfastandlowdosemultimodalphasecontrastimagingathighxrayenergy AT alessandroolivo largefieldofviewfastandlowdosemultimodalphasecontrastimagingathighxrayenergy
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Large field of view, fast and low dose multimodal phase-contrast imaging at high x-ray energy

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