Bone corticalization requires local SOCS3 activity and is promoted by androgen action via interleukin-6

The strength of long bones is determined by coalescence of trabeculae during corticalization. Here the authors show that this process is regulated by SOCS3 via a mechanism dependent on IL-6 and expression of sex hormones.

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Autores principales:	Dae-Chul Cho, Holly J. Brennan, Rachelle W. Johnson, Ingrid J. Poulton, Jonathan H. Gooi, Brett A. Tonkin, Narelle E. McGregor, Emma C. Walker, David J. Handelsman, T. J. Martin, Natalie A. Sims
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b957b83bc219453cadc23acf2a9623c9
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spelling	oai:doaj.org-article:b957b83bc219453cadc23acf2a9623c92021-12-02T15:38:47ZBone corticalization requires local SOCS3 activity and is promoted by androgen action via interleukin-610.1038/s41467-017-00920-x2041-1723https://doaj.org/article/b957b83bc219453cadc23acf2a9623c92017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00920-xhttps://doaj.org/toc/2041-1723The strength of long bones is determined by coalescence of trabeculae during corticalization. Here the authors show that this process is regulated by SOCS3 via a mechanism dependent on IL-6 and expression of sex hormones.Dae-Chul ChoHolly J. BrennanRachelle W. JohnsonIngrid J. PoultonJonathan H. GooiBrett A. TonkinNarelle E. McGregorEmma C. WalkerDavid J. HandelsmanT. J. MartinNatalie A. SimsNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dae-Chul Cho Holly J. Brennan Rachelle W. Johnson Ingrid J. Poulton Jonathan H. Gooi Brett A. Tonkin Narelle E. McGregor Emma C. Walker David J. Handelsman T. J. Martin Natalie A. Sims Bone corticalization requires local SOCS3 activity and is promoted by androgen action via interleukin-6
description	The strength of long bones is determined by coalescence of trabeculae during corticalization. Here the authors show that this process is regulated by SOCS3 via a mechanism dependent on IL-6 and expression of sex hormones.
format	article
author	Dae-Chul Cho Holly J. Brennan Rachelle W. Johnson Ingrid J. Poulton Jonathan H. Gooi Brett A. Tonkin Narelle E. McGregor Emma C. Walker David J. Handelsman T. J. Martin Natalie A. Sims
author_facet	Dae-Chul Cho Holly J. Brennan Rachelle W. Johnson Ingrid J. Poulton Jonathan H. Gooi Brett A. Tonkin Narelle E. McGregor Emma C. Walker David J. Handelsman T. J. Martin Natalie A. Sims
author_sort	Dae-Chul Cho
title	Bone corticalization requires local SOCS3 activity and is promoted by androgen action via interleukin-6
title_short	Bone corticalization requires local SOCS3 activity and is promoted by androgen action via interleukin-6
title_full	Bone corticalization requires local SOCS3 activity and is promoted by androgen action via interleukin-6
title_fullStr	Bone corticalization requires local SOCS3 activity and is promoted by androgen action via interleukin-6
title_full_unstemmed	Bone corticalization requires local SOCS3 activity and is promoted by androgen action via interleukin-6
title_sort	bone corticalization requires local socs3 activity and is promoted by androgen action via interleukin-6
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b957b83bc219453cadc23acf2a9623c9
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Bone corticalization requires local SOCS3 activity and is promoted by androgen action via interleukin-6

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