Role of musclin in the pathogenesis of hypertension in rat.

Musclin is a novel skeletal muscle-derived secretory factor found in the signal sequence trap of mouse skeletal muscle cDNAs. Musclin possesses a region homologous to the natriuretic peptide family. Thus, musclin is found to bind with the natriuretic peptide clearance receptors. However, the role of...

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Autores principales:	Ying-Xiao Li, Kai-Chun Cheng, Akihiro Asakawa, Ikuo Kato, Yuki Sato, Haruka Amitani, Namiko Kawamura, Juei-Tang Cheng, Akio Inui
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b95db03979c94154a9627783b5bf3da2
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spelling	oai:doaj.org-article:b95db03979c94154a9627783b5bf3da22021-11-18T09:01:06ZRole of musclin in the pathogenesis of hypertension in rat.1932-620310.1371/journal.pone.0072004https://doaj.org/article/b95db03979c94154a9627783b5bf3da22013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23940802/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Musclin is a novel skeletal muscle-derived secretory factor found in the signal sequence trap of mouse skeletal muscle cDNAs. Musclin possesses a region homologous to the natriuretic peptide family. Thus, musclin is found to bind with the natriuretic peptide clearance receptors. However, the role of musclin in vascular regulation remains unclear. In this study, we aim to investigate the direct effect of musclin on vascular tone and to analyze its role in hypertension using the spontaneously hypertensive rats (SHR). In aortic strips isolated from SHR, musclin induced contractions in a dose-dependent manner. We found that the musclin-induced vasoconstriction was more marked in SHR than in normal rats (WKY). Moreover, this contraction was reduced by blockade of natriuretic peptide receptor C using the ab14355 antibody. Therefore, mediation of the natriuretic peptide receptor in musclin-induced vasoconstriction can be considered. In addition, similar to the natriuretic peptide receptor, expression of the musclin gene in blood vessels was higher in SHR than in WKY. Injection of musclin markedly increased the blood pressure in rats that can be inhibited by anti-musclin antibodies. Musclin-induced vasoconstriction was more pronounced in SHR than in WKY as in its expression. Taken together, these results suggest that musclin is involved in blood pressure regulation. The higher expression of musclin in hypertension indicates that musclin could be used as a new target for the treatment of hypertension in the future.Ying-Xiao LiKai-Chun ChengAkihiro AsakawaIkuo KatoYuki SatoHaruka AmitaniNamiko KawamuraJuei-Tang ChengAkio InuiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 8, p e72004 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ying-Xiao Li Kai-Chun Cheng Akihiro Asakawa Ikuo Kato Yuki Sato Haruka Amitani Namiko Kawamura Juei-Tang Cheng Akio Inui Role of musclin in the pathogenesis of hypertension in rat.
description	Musclin is a novel skeletal muscle-derived secretory factor found in the signal sequence trap of mouse skeletal muscle cDNAs. Musclin possesses a region homologous to the natriuretic peptide family. Thus, musclin is found to bind with the natriuretic peptide clearance receptors. However, the role of musclin in vascular regulation remains unclear. In this study, we aim to investigate the direct effect of musclin on vascular tone and to analyze its role in hypertension using the spontaneously hypertensive rats (SHR). In aortic strips isolated from SHR, musclin induced contractions in a dose-dependent manner. We found that the musclin-induced vasoconstriction was more marked in SHR than in normal rats (WKY). Moreover, this contraction was reduced by blockade of natriuretic peptide receptor C using the ab14355 antibody. Therefore, mediation of the natriuretic peptide receptor in musclin-induced vasoconstriction can be considered. In addition, similar to the natriuretic peptide receptor, expression of the musclin gene in blood vessels was higher in SHR than in WKY. Injection of musclin markedly increased the blood pressure in rats that can be inhibited by anti-musclin antibodies. Musclin-induced vasoconstriction was more pronounced in SHR than in WKY as in its expression. Taken together, these results suggest that musclin is involved in blood pressure regulation. The higher expression of musclin in hypertension indicates that musclin could be used as a new target for the treatment of hypertension in the future.
format	article
author	Ying-Xiao Li Kai-Chun Cheng Akihiro Asakawa Ikuo Kato Yuki Sato Haruka Amitani Namiko Kawamura Juei-Tang Cheng Akio Inui
author_facet	Ying-Xiao Li Kai-Chun Cheng Akihiro Asakawa Ikuo Kato Yuki Sato Haruka Amitani Namiko Kawamura Juei-Tang Cheng Akio Inui
author_sort	Ying-Xiao Li
title	Role of musclin in the pathogenesis of hypertension in rat.
title_short	Role of musclin in the pathogenesis of hypertension in rat.
title_full	Role of musclin in the pathogenesis of hypertension in rat.
title_fullStr	Role of musclin in the pathogenesis of hypertension in rat.
title_full_unstemmed	Role of musclin in the pathogenesis of hypertension in rat.
title_sort	role of musclin in the pathogenesis of hypertension in rat.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/b95db03979c94154a9627783b5bf3da2
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Role of musclin in the pathogenesis of hypertension in rat.

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