Cardiovascular health and risk of hospitalization with COVID-19: A Mendelian Randomization study

Background Susceptibility to and severity of COVID-19 is associated with risk factors for and presence of cardiovascular disease. Methods We performed a 2-sample Mendelian randomization to determine whether blood pressure (BP), body mass index (BMI), presence of type 2 diabetes (T2DM) and coronary a...

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Autores principales:	Marina Cecelja, Cathryn M. Lewis, Ajay M. Shah, Phil Chowienczyk
Formato:	article
Lenguaje:	EN
Publicado:	SAGE Publishing 2021
Materias:	Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/b95f28ba089b496eb86b0c27d3ac0322
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spelling	oai:doaj.org-article:b95f28ba089b496eb86b0c27d3ac03222021-11-19T23:03:23ZCardiovascular health and risk of hospitalization with COVID-19: A Mendelian Randomization study2048-004010.1177/20480040211059374https://doaj.org/article/b95f28ba089b496eb86b0c27d3ac03222021-11-01T00:00:00Zhttps://doi.org/10.1177/20480040211059374https://doaj.org/toc/2048-0040Background Susceptibility to and severity of COVID-19 is associated with risk factors for and presence of cardiovascular disease. Methods We performed a 2-sample Mendelian randomization to determine whether blood pressure (BP), body mass index (BMI), presence of type 2 diabetes (T2DM) and coronary artery disease (CAD) are causally related to presentation with severe COVID-19. Variant-exposure instrumental variable associations were determined from most recently published genome-wide association and meta-analysis studies (GWAS) with publicly available summary-level GWAS data. Variant-outcome associations were obtained from a recent GWAS meta-analysis of laboratory confirmed diagnosis of COVID-19 with severity determined according to need for hospitalization/death. We also examined reverse causality using exposure as diagnosis of severe COVID-19 causing cardiovascular disease. Results We found no evidence for a causal association of cardiovascular risk factors/disease with severe COVID-19 (compared to population controls), nor evidence of reverse causality. Causal odds ratios (OR, by inverse variance weighted regression) for BP (OR for COVID-19 diagnosis 1.00 [95% confidence interval (CI): 0.99–1.01, P = 0.604] per genetically predicted increase in BP) and T2DM (OR for COVID-19 diagnosis to that of genetically predicted T2DM 1.02 [95% CI: 0.9–1.05, P = 0.927], in particular, were close to unity with relatively narrow confidence intervals. Conclusion The association between cardiovascular risk factors/disease with that of hospitalization with COVID-19 reported in observational studies could be due to residual confounding by socioeconomic factors and /or those that influence the indication for hospital admission.Marina CeceljaCathryn M. Lewis Ajay M. ShahPhil ChowienczykSAGE PublishingarticleDiseases of the circulatory (Cardiovascular) systemRC666-701ENJRSM Cardiovascular Disease, Vol 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	Diseases of the circulatory (Cardiovascular) system RC666-701 Marina Cecelja Cathryn M. Lewis Ajay M. Shah Phil Chowienczyk Cardiovascular health and risk of hospitalization with COVID-19: A Mendelian Randomization study
description	Background Susceptibility to and severity of COVID-19 is associated with risk factors for and presence of cardiovascular disease. Methods We performed a 2-sample Mendelian randomization to determine whether blood pressure (BP), body mass index (BMI), presence of type 2 diabetes (T2DM) and coronary artery disease (CAD) are causally related to presentation with severe COVID-19. Variant-exposure instrumental variable associations were determined from most recently published genome-wide association and meta-analysis studies (GWAS) with publicly available summary-level GWAS data. Variant-outcome associations were obtained from a recent GWAS meta-analysis of laboratory confirmed diagnosis of COVID-19 with severity determined according to need for hospitalization/death. We also examined reverse causality using exposure as diagnosis of severe COVID-19 causing cardiovascular disease. Results We found no evidence for a causal association of cardiovascular risk factors/disease with severe COVID-19 (compared to population controls), nor evidence of reverse causality. Causal odds ratios (OR, by inverse variance weighted regression) for BP (OR for COVID-19 diagnosis 1.00 [95% confidence interval (CI): 0.99–1.01, P = 0.604] per genetically predicted increase in BP) and T2DM (OR for COVID-19 diagnosis to that of genetically predicted T2DM 1.02 [95% CI: 0.9–1.05, P = 0.927], in particular, were close to unity with relatively narrow confidence intervals. Conclusion The association between cardiovascular risk factors/disease with that of hospitalization with COVID-19 reported in observational studies could be due to residual confounding by socioeconomic factors and /or those that influence the indication for hospital admission.
format	article
author	Marina Cecelja Cathryn M. Lewis Ajay M. Shah Phil Chowienczyk
author_facet	Marina Cecelja Cathryn M. Lewis Ajay M. Shah Phil Chowienczyk
author_sort	Marina Cecelja
title	Cardiovascular health and risk of hospitalization with COVID-19: A Mendelian Randomization study
title_short	Cardiovascular health and risk of hospitalization with COVID-19: A Mendelian Randomization study
title_full	Cardiovascular health and risk of hospitalization with COVID-19: A Mendelian Randomization study
title_fullStr	Cardiovascular health and risk of hospitalization with COVID-19: A Mendelian Randomization study
title_full_unstemmed	Cardiovascular health and risk of hospitalization with COVID-19: A Mendelian Randomization study
title_sort	cardiovascular health and risk of hospitalization with covid-19: a mendelian randomization study
publisher	SAGE Publishing
publishDate	2021
url	https://doaj.org/article/b95f28ba089b496eb86b0c27d3ac0322
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Cardiovascular health and risk of hospitalization with COVID-19: A Mendelian Randomization study

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