Approach to Neurological Channelopathies and Neurometabolic Disorders in Newborns

Ion channel disorders (channelopathies) can affect any organ system in newborns before 2 months of life, including the skeletal muscle and central nervous system. Channelopathies in newborns can manifest as seizure disorders, which is a critical issue as early onset seizures can mimic the presentati...

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Autor principal:	Inn-Chi Lee
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	channelopathies neurometabolic newborns seizures Science Q
Acceso en línea:	https://doaj.org/article/b960547630964c54a94b9265a8d8b094
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spelling	oai:doaj.org-article:b960547630964c54a94b9265a8d8b0942021-11-25T18:11:30ZApproach to Neurological Channelopathies and Neurometabolic Disorders in Newborns10.3390/life111112442075-1729https://doaj.org/article/b960547630964c54a94b9265a8d8b0942021-11-01T00:00:00Zhttps://www.mdpi.com/2075-1729/11/11/1244https://doaj.org/toc/2075-1729Ion channel disorders (channelopathies) can affect any organ system in newborns before 2 months of life, including the skeletal muscle and central nervous system. Channelopathies in newborns can manifest as seizure disorders, which is a critical issue as early onset seizures can mimic the presentation of neurometabolic disorders. Seizures in channelopathies can either be focal or generalized, and range in severity from benign to epileptic encephalopathies that may lead to developmental regression and eventually premature death. The presenting symptoms of channelopathies are challenging for clinicians to decipher, such that an extensive diagnostic survey through a precise step-by-step process is vital. Early diagnosis of a newborn’s disease, either as a channelopathy or neurometabolic disorder, is important for the long-term neurodevelopment of the child.Inn-Chi LeeMDPI AGarticlechannelopathiesneurometabolicnewbornsseizuresScienceQENLife, Vol 11, Iss 1244, p 1244 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	channelopathies neurometabolic newborns seizures Science Q
spellingShingle	channelopathies neurometabolic newborns seizures Science Q Inn-Chi Lee Approach to Neurological Channelopathies and Neurometabolic Disorders in Newborns
description	Ion channel disorders (channelopathies) can affect any organ system in newborns before 2 months of life, including the skeletal muscle and central nervous system. Channelopathies in newborns can manifest as seizure disorders, which is a critical issue as early onset seizures can mimic the presentation of neurometabolic disorders. Seizures in channelopathies can either be focal or generalized, and range in severity from benign to epileptic encephalopathies that may lead to developmental regression and eventually premature death. The presenting symptoms of channelopathies are challenging for clinicians to decipher, such that an extensive diagnostic survey through a precise step-by-step process is vital. Early diagnosis of a newborn’s disease, either as a channelopathy or neurometabolic disorder, is important for the long-term neurodevelopment of the child.
format	article
author	Inn-Chi Lee
author_facet	Inn-Chi Lee
author_sort	Inn-Chi Lee
title	Approach to Neurological Channelopathies and Neurometabolic Disorders in Newborns
title_short	Approach to Neurological Channelopathies and Neurometabolic Disorders in Newborns
title_full	Approach to Neurological Channelopathies and Neurometabolic Disorders in Newborns
title_fullStr	Approach to Neurological Channelopathies and Neurometabolic Disorders in Newborns
title_full_unstemmed	Approach to Neurological Channelopathies and Neurometabolic Disorders in Newborns
title_sort	approach to neurological channelopathies and neurometabolic disorders in newborns
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b960547630964c54a94b9265a8d8b094
work_keys_str_mv	AT innchilee approachtoneurologicalchannelopathiesandneurometabolicdisordersinnewborns
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Approach to Neurological Channelopathies and Neurometabolic Disorders in Newborns

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