Integrating genome and transcriptome profiling for elucidating the mechanism of muscle growth and lipid deposition in Pekin ducks

Abstract Muscle growth and lipid deposition are co-ordinately regulated processes. Cherry Valley Pekin duck is a lean-type duck breed with high growth rate, whereas the native Pekin duck of China has high lipid deposition. Phenotypic analysis showed that native Pekin ducks have smaller fibre diamete...

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Autores principales:	Liyuan Wang, Xiangxiang Li, Jun Ma, Yawen Zhang, Hao Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b960dac54b4a4743bfc59b2426a0c151
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spelling	oai:doaj.org-article:b960dac54b4a4743bfc59b2426a0c1512021-12-02T15:06:21ZIntegrating genome and transcriptome profiling for elucidating the mechanism of muscle growth and lipid deposition in Pekin ducks10.1038/s41598-017-04178-72045-2322https://doaj.org/article/b960dac54b4a4743bfc59b2426a0c1512017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04178-7https://doaj.org/toc/2045-2322Abstract Muscle growth and lipid deposition are co-ordinately regulated processes. Cherry Valley Pekin duck is a lean-type duck breed with high growth rate, whereas the native Pekin duck of China has high lipid deposition. Phenotypic analysis showed that native Pekin ducks have smaller fibre diameter and larger density in the breast muscle at 3 weeks of age and higher intramuscular fat content at 6 weeks of age than those in Cherry Valley Pekin ducks. We detected 17 positively selected genes (PSGs) by comparing genes mainly involved with muscle organ development, muscle contraction, peroxisome proliferator activated receptor signalling pathway, and fatty acid metabolism. In all, 52 and 206 differentially expressed genes (DEGs) were identified in transcriptomic comparisons between the two breeds at 3 and 6 weeks of age, respectively, which could potentially affect muscle growth and lipid deposition. Based on the integration of PSGs and DEGs and their functional annotations, we found that 11 and 10 genes were correlated with muscle growth and lipid deposition, respectively. Identification of candidate genes controlling quantitative traits of duck muscle might aid in elucidating the mechanisms of muscle growth and lipid deposition and could help in improving duck breeding.Liyuan WangXiangxiang LiJun MaYawen ZhangHao ZhangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Liyuan Wang Xiangxiang Li Jun Ma Yawen Zhang Hao Zhang Integrating genome and transcriptome profiling for elucidating the mechanism of muscle growth and lipid deposition in Pekin ducks
description	Abstract Muscle growth and lipid deposition are co-ordinately regulated processes. Cherry Valley Pekin duck is a lean-type duck breed with high growth rate, whereas the native Pekin duck of China has high lipid deposition. Phenotypic analysis showed that native Pekin ducks have smaller fibre diameter and larger density in the breast muscle at 3 weeks of age and higher intramuscular fat content at 6 weeks of age than those in Cherry Valley Pekin ducks. We detected 17 positively selected genes (PSGs) by comparing genes mainly involved with muscle organ development, muscle contraction, peroxisome proliferator activated receptor signalling pathway, and fatty acid metabolism. In all, 52 and 206 differentially expressed genes (DEGs) were identified in transcriptomic comparisons between the two breeds at 3 and 6 weeks of age, respectively, which could potentially affect muscle growth and lipid deposition. Based on the integration of PSGs and DEGs and their functional annotations, we found that 11 and 10 genes were correlated with muscle growth and lipid deposition, respectively. Identification of candidate genes controlling quantitative traits of duck muscle might aid in elucidating the mechanisms of muscle growth and lipid deposition and could help in improving duck breeding.
format	article
author	Liyuan Wang Xiangxiang Li Jun Ma Yawen Zhang Hao Zhang
author_facet	Liyuan Wang Xiangxiang Li Jun Ma Yawen Zhang Hao Zhang
author_sort	Liyuan Wang
title	Integrating genome and transcriptome profiling for elucidating the mechanism of muscle growth and lipid deposition in Pekin ducks
title_short	Integrating genome and transcriptome profiling for elucidating the mechanism of muscle growth and lipid deposition in Pekin ducks
title_full	Integrating genome and transcriptome profiling for elucidating the mechanism of muscle growth and lipid deposition in Pekin ducks
title_fullStr	Integrating genome and transcriptome profiling for elucidating the mechanism of muscle growth and lipid deposition in Pekin ducks
title_full_unstemmed	Integrating genome and transcriptome profiling for elucidating the mechanism of muscle growth and lipid deposition in Pekin ducks
title_sort	integrating genome and transcriptome profiling for elucidating the mechanism of muscle growth and lipid deposition in pekin ducks
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b960dac54b4a4743bfc59b2426a0c151
work_keys_str_mv	AT liyuanwang integratinggenomeandtranscriptomeprofilingforelucidatingthemechanismofmusclegrowthandlipiddepositioninpekinducks AT xiangxiangli integratinggenomeandtranscriptomeprofilingforelucidatingthemechanismofmusclegrowthandlipiddepositioninpekinducks AT junma integratinggenomeandtranscriptomeprofilingforelucidatingthemechanismofmusclegrowthandlipiddepositioninpekinducks AT yawenzhang integratinggenomeandtranscriptomeprofilingforelucidatingthemechanismofmusclegrowthandlipiddepositioninpekinducks AT haozhang integratinggenomeandtranscriptomeprofilingforelucidatingthemechanismofmusclegrowthandlipiddepositioninpekinducks
_version_	1718388475202371584

Integrating genome and transcriptome profiling for elucidating the mechanism of muscle growth and lipid deposition in Pekin ducks

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