Features of glycemic variations in drug naïve type 2 diabetic patients with different HbA1c values

Abstract To define the features of glycemic variations in drug naïve type 2 diabetic (T2D) patients with different HbA1c values using continuous glucose monitoring (CGM), a total of 195 drug naïve T2D patients were admitted. The subjects were divided into the following groups: lower HbA1c values (≤8...

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Autores principales:	Feng-fei Li, Bing-li Liu, Reng-na Yan, Hong-hong Zhu, Pei-hua Zhou, Hui-qin Li, Xiao-fei Su, Jin-dan Wu, Dan-feng Zhang, Lei Ye, Jian-hua Ma
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b96179670feb4674a1e955376173cb4a
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spelling	oai:doaj.org-article:b96179670feb4674a1e955376173cb4a2021-12-02T12:31:49ZFeatures of glycemic variations in drug naïve type 2 diabetic patients with different HbA1c values10.1038/s41598-017-01719-y2045-2322https://doaj.org/article/b96179670feb4674a1e955376173cb4a2017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01719-yhttps://doaj.org/toc/2045-2322Abstract To define the features of glycemic variations in drug naïve type 2 diabetic (T2D) patients with different HbA1c values using continuous glucose monitoring (CGM), a total of 195 drug naïve T2D patients were admitted. The subjects were divided into the following groups: lower HbA1c values (≤8%), moderate HbA1c values (>8% and ≤10%), and higher HbA1c values (>10%). The patients underwent oral glucose tolerance tests and were then subjected to 3-day CGM. The primary endpoint was the differences in the 24-hr mean amplitude of glycemic excursions (MAGE) in patients with different HbA1c values. Patients with higher HbA1c values had larger MAGEs than those in the moderate and lower groups (7.44 ± 3.00 vs. 6.30 ± 2.38, P < 0.05, 7.44 ± 3.00 vs. 5.20 ± 2.35, P < 0.01, respectively). The 24-hr mean glucose concentrations increased incrementally in the patients with lower, moderate and higher HbA1c values. Moreover, the patients with higher HbA1c values exhibited higher peak glucose concentrations and prolongation in the time to peak glucose. Patients with higher HbA1c values had larger MAGE compared with those with lower and moderate HbA1c values. Our data indicated patients with higher HbA1c values should receive special therapy aimed at reducing the larger glycemic variations.Feng-fei LiBing-li LiuReng-na YanHong-hong ZhuPei-hua ZhouHui-qin LiXiao-fei SuJin-dan WuDan-feng ZhangLei YeJian-hua MaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Feng-fei Li Bing-li Liu Reng-na Yan Hong-hong Zhu Pei-hua Zhou Hui-qin Li Xiao-fei Su Jin-dan Wu Dan-feng Zhang Lei Ye Jian-hua Ma Features of glycemic variations in drug naïve type 2 diabetic patients with different HbA1c values
description	Abstract To define the features of glycemic variations in drug naïve type 2 diabetic (T2D) patients with different HbA1c values using continuous glucose monitoring (CGM), a total of 195 drug naïve T2D patients were admitted. The subjects were divided into the following groups: lower HbA1c values (≤8%), moderate HbA1c values (>8% and ≤10%), and higher HbA1c values (>10%). The patients underwent oral glucose tolerance tests and were then subjected to 3-day CGM. The primary endpoint was the differences in the 24-hr mean amplitude of glycemic excursions (MAGE) in patients with different HbA1c values. Patients with higher HbA1c values had larger MAGEs than those in the moderate and lower groups (7.44 ± 3.00 vs. 6.30 ± 2.38, P < 0.05, 7.44 ± 3.00 vs. 5.20 ± 2.35, P < 0.01, respectively). The 24-hr mean glucose concentrations increased incrementally in the patients with lower, moderate and higher HbA1c values. Moreover, the patients with higher HbA1c values exhibited higher peak glucose concentrations and prolongation in the time to peak glucose. Patients with higher HbA1c values had larger MAGE compared with those with lower and moderate HbA1c values. Our data indicated patients with higher HbA1c values should receive special therapy aimed at reducing the larger glycemic variations.
format	article
author	Feng-fei Li Bing-li Liu Reng-na Yan Hong-hong Zhu Pei-hua Zhou Hui-qin Li Xiao-fei Su Jin-dan Wu Dan-feng Zhang Lei Ye Jian-hua Ma
author_facet	Feng-fei Li Bing-li Liu Reng-na Yan Hong-hong Zhu Pei-hua Zhou Hui-qin Li Xiao-fei Su Jin-dan Wu Dan-feng Zhang Lei Ye Jian-hua Ma
author_sort	Feng-fei Li
title	Features of glycemic variations in drug naïve type 2 diabetic patients with different HbA1c values
title_short	Features of glycemic variations in drug naïve type 2 diabetic patients with different HbA1c values
title_full	Features of glycemic variations in drug naïve type 2 diabetic patients with different HbA1c values
title_fullStr	Features of glycemic variations in drug naïve type 2 diabetic patients with different HbA1c values
title_full_unstemmed	Features of glycemic variations in drug naïve type 2 diabetic patients with different HbA1c values
title_sort	features of glycemic variations in drug naïve type 2 diabetic patients with different hba1c values
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b96179670feb4674a1e955376173cb4a
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Features of glycemic variations in drug naïve type 2 diabetic patients with different HbA1c values

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