Frequencies of the T-455C and C-482T apoCIII gene polymorphisms in different South African population groups and their relationship to fasting serum triglyceride levels

Studies have demonstrated that serum triglyceride levels are higher in Indian and White than Black South African subjects. Polymorphisms in the apoCIII gene have been associated with raised triglyceride levels. This study investigated the prevalence of apoCIII polymorphisms and their effect on trigl...

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Autores principales:	N.H. Naran, F.J. Raal, N.J. Crowther
Formato:	article
Lenguaje:	EN
Publicado:	South African Heart Association 2017
Materias:	apolipoprotein ciii (apociii) south africa serum triglyceride levels Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/b96213cab5724babbd1b0b285692165d
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spelling	oai:doaj.org-article:b96213cab5724babbd1b0b285692165d2021-11-22T08:33:00ZFrequencies of the T-455C and C-482T apoCIII gene polymorphisms in different South African population groups and their relationship to fasting serum triglyceride levels10.24170/6-3-19851996-67412071-4602https://doaj.org/article/b96213cab5724babbd1b0b285692165d2017-04-01T00:00:00Zhttps://www.journals.ac.za/index.php/SAHJ/article/view/1985https://doaj.org/toc/1996-6741https://doaj.org/toc/2071-4602Studies have demonstrated that serum triglyceride levels are higher in Indian and White than Black South African subjects. Polymorphisms in the apoCIII gene have been associated with raised triglyceride levels. This study investigated the prevalence of apoCIII polymorphisms and their effect on triglyceride levels in three South African population groups and in subjects with fasting hypertriglyceridaemia (HT). Two apoCIII polymorphic sites (T-455C and C-482T) were studied in 78 European, 24 Indian and 25 African subjects. Each ethnic group included HT and non-HT (control) patients. Although triglyceride levels were much higher in the HT subjects, no significant differences were noted between the groups for allele or genotype frequencies at either apoCIII locus. Furthermore, at neither locus was there an association between the genotype and serum triglyceride levels. The HT and control subjects were therefore combined and ethnic differences in allele frequencies were investigated. The African subjects had a higher frequency (0.79) of the unfavourable C allele at position 455 than both Indian (0.56; p‹0.05) and European (0.41; p‹0.0005) subjects. Furthermore, African subjects had a higher frequency (0.77) of the unfavourable T allele at locus 482 than Indian (0.44, p‹0.005) and European (0.36, p‹0.0005) subjects despite triglyceride levels being lower in the African (0.60 [1.60] mmol/l) than European (0.90 [0.40] mmol/l; p‹0.05) control subjects. These results suggest that the apoCIII polymorphisms studied do not contribute to the raised triglyceride levels in HT subjects and do not explain the ethnic differences observed in fasting serum triglyceride levels.N.H. NaranF.J. RaalN.J. CrowtherSouth African Heart Associationarticleapolipoprotein ciii (apociii)south africaserum triglyceride levelsDiseases of the circulatory (Cardiovascular) systemRC666-701ENSA Heart Journal, Vol 6, Iss 3, Pp 162-167 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	apolipoprotein ciii (apociii) south africa serum triglyceride levels Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	apolipoprotein ciii (apociii) south africa serum triglyceride levels Diseases of the circulatory (Cardiovascular) system RC666-701 N.H. Naran F.J. Raal N.J. Crowther Frequencies of the T-455C and C-482T apoCIII gene polymorphisms in different South African population groups and their relationship to fasting serum triglyceride levels
description	Studies have demonstrated that serum triglyceride levels are higher in Indian and White than Black South African subjects. Polymorphisms in the apoCIII gene have been associated with raised triglyceride levels. This study investigated the prevalence of apoCIII polymorphisms and their effect on triglyceride levels in three South African population groups and in subjects with fasting hypertriglyceridaemia (HT). Two apoCIII polymorphic sites (T-455C and C-482T) were studied in 78 European, 24 Indian and 25 African subjects. Each ethnic group included HT and non-HT (control) patients. Although triglyceride levels were much higher in the HT subjects, no significant differences were noted between the groups for allele or genotype frequencies at either apoCIII locus. Furthermore, at neither locus was there an association between the genotype and serum triglyceride levels. The HT and control subjects were therefore combined and ethnic differences in allele frequencies were investigated. The African subjects had a higher frequency (0.79) of the unfavourable C allele at position 455 than both Indian (0.56; p‹0.05) and European (0.41; p‹0.0005) subjects. Furthermore, African subjects had a higher frequency (0.77) of the unfavourable T allele at locus 482 than Indian (0.44, p‹0.005) and European (0.36, p‹0.0005) subjects despite triglyceride levels being lower in the African (0.60 [1.60] mmol/l) than European (0.90 [0.40] mmol/l; p‹0.05) control subjects. These results suggest that the apoCIII polymorphisms studied do not contribute to the raised triglyceride levels in HT subjects and do not explain the ethnic differences observed in fasting serum triglyceride levels.
format	article
author	N.H. Naran F.J. Raal N.J. Crowther
author_facet	N.H. Naran F.J. Raal N.J. Crowther
author_sort	N.H. Naran
title	Frequencies of the T-455C and C-482T apoCIII gene polymorphisms in different South African population groups and their relationship to fasting serum triglyceride levels
title_short	Frequencies of the T-455C and C-482T apoCIII gene polymorphisms in different South African population groups and their relationship to fasting serum triglyceride levels
title_full	Frequencies of the T-455C and C-482T apoCIII gene polymorphisms in different South African population groups and their relationship to fasting serum triglyceride levels
title_fullStr	Frequencies of the T-455C and C-482T apoCIII gene polymorphisms in different South African population groups and their relationship to fasting serum triglyceride levels
title_full_unstemmed	Frequencies of the T-455C and C-482T apoCIII gene polymorphisms in different South African population groups and their relationship to fasting serum triglyceride levels
title_sort	frequencies of the t-455c and c-482t apociii gene polymorphisms in different south african population groups and their relationship to fasting serum triglyceride levels
publisher	South African Heart Association
publishDate	2017
url	https://doaj.org/article/b96213cab5724babbd1b0b285692165d
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Frequencies of the T-455C and C-482T apoCIII gene polymorphisms in different South African population groups and their relationship to fasting serum triglyceride levels

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