Anti-infection mechanism of a novel dental implant made of titanium-copper (TiCu) alloy and its mechanism associated with oral microbiology
This work was focused on study of anti-infection ability and its underlying mechanism of a novel dental implant made of titanium-copper (TiCu) alloy. In general, most studies on antibacterial implants have used a single pathogen to test their anti-infection ability using infectious animal models. Ho...
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KeAi Communications Co., Ltd.
2022
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oai:doaj.org-article:b962b7762f7d4c3aa9bf395a51f158292021-11-04T04:34:41ZAnti-infection mechanism of a novel dental implant made of titanium-copper (TiCu) alloy and its mechanism associated with oral microbiology2452-199X10.1016/j.bioactmat.2021.05.053https://doaj.org/article/b962b7762f7d4c3aa9bf395a51f158292022-02-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2452199X21002747https://doaj.org/toc/2452-199XThis work was focused on study of anti-infection ability and its underlying mechanism of a novel dental implant made of titanium-copper (TiCu) alloy. In general, most studies on antibacterial implants have used a single pathogen to test their anti-infection ability using infectious animal models. However, dental implant-associated infections are polymicrobial diseases. We innovatively combine the classic ligature model in dogs with sucrose-rich diets to induce oral infections via the canine native oral bacteria. The anti-infection ability, biocompatibility and underlying mechanism of TiCu implant were systematically investigated in comparison with pure Ti implant via general inspection, hematology, imageology (micro-CT), microbiology (16S rDNA and metagenome), histology, and Cu ion detections. Compared with Ti implant, TiCu implant demonstrated remarkable anti-infection potentials with excellent biocompatibility. Additionally, the underlying anti-infection mechanism of TiCu implant was considered to involve maintaining the oral microbiota homeostasis. It was found that the carbohydrates in the plaques formed on the surface of TiCu implant were metabolized through the tricarboxylic acid cycle (TCA) cycles, which prevented the formation of an acidic microenvironment and inhibited the accumulation of acidogens and pathogens, thereby maintaining the microflora balance between aerobic and anaerobic bacteria.Hui LiuYulong TangShuyuan ZhangHuan LiuZijian WangYue LiXinluan WangLing RenKe YangLing QinKeAi Communications Co., Ltd.articleTitanium-copper alloy implantsAnti-infectionOral microbiologyBiosafetyMaterials of engineering and construction. Mechanics of materialsTA401-492Biology (General)QH301-705.5ENBioactive Materials, Vol 8, Iss , Pp 381-395 (2022) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Titanium-copper alloy implants Anti-infection Oral microbiology Biosafety Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5 |
| spellingShingle |
Titanium-copper alloy implants Anti-infection Oral microbiology Biosafety Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5 Hui Liu Yulong Tang Shuyuan Zhang Huan Liu Zijian Wang Yue Li Xinluan Wang Ling Ren Ke Yang Ling Qin Anti-infection mechanism of a novel dental implant made of titanium-copper (TiCu) alloy and its mechanism associated with oral microbiology |
| description |
This work was focused on study of anti-infection ability and its underlying mechanism of a novel dental implant made of titanium-copper (TiCu) alloy. In general, most studies on antibacterial implants have used a single pathogen to test their anti-infection ability using infectious animal models. However, dental implant-associated infections are polymicrobial diseases. We innovatively combine the classic ligature model in dogs with sucrose-rich diets to induce oral infections via the canine native oral bacteria. The anti-infection ability, biocompatibility and underlying mechanism of TiCu implant were systematically investigated in comparison with pure Ti implant via general inspection, hematology, imageology (micro-CT), microbiology (16S rDNA and metagenome), histology, and Cu ion detections. Compared with Ti implant, TiCu implant demonstrated remarkable anti-infection potentials with excellent biocompatibility. Additionally, the underlying anti-infection mechanism of TiCu implant was considered to involve maintaining the oral microbiota homeostasis. It was found that the carbohydrates in the plaques formed on the surface of TiCu implant were metabolized through the tricarboxylic acid cycle (TCA) cycles, which prevented the formation of an acidic microenvironment and inhibited the accumulation of acidogens and pathogens, thereby maintaining the microflora balance between aerobic and anaerobic bacteria. |
| format |
article |
| author |
Hui Liu Yulong Tang Shuyuan Zhang Huan Liu Zijian Wang Yue Li Xinluan Wang Ling Ren Ke Yang Ling Qin |
| author_facet |
Hui Liu Yulong Tang Shuyuan Zhang Huan Liu Zijian Wang Yue Li Xinluan Wang Ling Ren Ke Yang Ling Qin |
| author_sort |
Hui Liu |
| title |
Anti-infection mechanism of a novel dental implant made of titanium-copper (TiCu) alloy and its mechanism associated with oral microbiology |
| title_short |
Anti-infection mechanism of a novel dental implant made of titanium-copper (TiCu) alloy and its mechanism associated with oral microbiology |
| title_full |
Anti-infection mechanism of a novel dental implant made of titanium-copper (TiCu) alloy and its mechanism associated with oral microbiology |
| title_fullStr |
Anti-infection mechanism of a novel dental implant made of titanium-copper (TiCu) alloy and its mechanism associated with oral microbiology |
| title_full_unstemmed |
Anti-infection mechanism of a novel dental implant made of titanium-copper (TiCu) alloy and its mechanism associated with oral microbiology |
| title_sort |
anti-infection mechanism of a novel dental implant made of titanium-copper (ticu) alloy and its mechanism associated with oral microbiology |
| publisher |
KeAi Communications Co., Ltd. |
| publishDate |
2022 |
| url |
https://doaj.org/article/b962b7762f7d4c3aa9bf395a51f15829 |
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