Hepatitis B virus cccDNA is formed through distinct repair processes of each strand
HBV covalently closed circular DNA (cccDNA) enables and persists in chronic infection, but the molecular mechanism of its formation is unclear. Here, Wei and Ploss elucidate the detailed kinetics and biochemical steps by which the relaxed circular DNA is converted into cccDNA.
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Nature Portfolio
2021
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oai:doaj.org-article:b96aff000413433990fa3837998d3a432021-12-02T15:53:25ZHepatitis B virus cccDNA is formed through distinct repair processes of each strand10.1038/s41467-021-21850-92041-1723https://doaj.org/article/b96aff000413433990fa3837998d3a432021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21850-9https://doaj.org/toc/2041-1723HBV covalently closed circular DNA (cccDNA) enables and persists in chronic infection, but the molecular mechanism of its formation is unclear. Here, Wei and Ploss elucidate the detailed kinetics and biochemical steps by which the relaxed circular DNA is converted into cccDNA.Lei WeiAlexander PlossNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021) |
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DOAJ |
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DOAJ |
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EN |
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Science Q |
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Science Q Lei Wei Alexander Ploss Hepatitis B virus cccDNA is formed through distinct repair processes of each strand |
| description |
HBV covalently closed circular DNA (cccDNA) enables and persists in chronic infection, but the molecular mechanism of its formation is unclear. Here, Wei and Ploss elucidate the detailed kinetics and biochemical steps by which the relaxed circular DNA is converted into cccDNA. |
| format |
article |
| author |
Lei Wei Alexander Ploss |
| author_facet |
Lei Wei Alexander Ploss |
| author_sort |
Lei Wei |
| title |
Hepatitis B virus cccDNA is formed through distinct repair processes of each strand |
| title_short |
Hepatitis B virus cccDNA is formed through distinct repair processes of each strand |
| title_full |
Hepatitis B virus cccDNA is formed through distinct repair processes of each strand |
| title_fullStr |
Hepatitis B virus cccDNA is formed through distinct repair processes of each strand |
| title_full_unstemmed |
Hepatitis B virus cccDNA is formed through distinct repair processes of each strand |
| title_sort |
hepatitis b virus cccdna is formed through distinct repair processes of each strand |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/b96aff000413433990fa3837998d3a43 |
| work_keys_str_mv |
AT leiwei hepatitisbviruscccdnaisformedthroughdistinctrepairprocessesofeachstrand AT alexanderploss hepatitisbviruscccdnaisformedthroughdistinctrepairprocessesofeachstrand |
| _version_ |
1718385532487073792 |