Hepatitis B virus cccDNA is formed through distinct repair processes of each strand

HBV covalently closed circular DNA (cccDNA) enables and persists in chronic infection, but the molecular mechanism of its formation is unclear. Here, Wei and Ploss elucidate the detailed kinetics and biochemical steps by which the relaxed circular DNA is converted into cccDNA.

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Autores principales: Lei Wei, Alexander Ploss
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/b96aff000413433990fa3837998d3a43
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