Correlation between early features and prognosis of symptomatic COVID-19 discharged patients in Hunan, China

Abstract To determine the correlation between the clinical, laboratory, and radiological findings and the hospitalization days in Coronavirus Infectious Disease-19 (COVID-19) discharged patients. We retrospectively identified 172 discharged patients with COVID-19 pneumonia from January 10, 2020, to...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yeyu Cai, Jiayi Liu, Haitao Yang, Taili Chen, Qizhi Yu, Juan Chen, Deng Huang, Zhu Chen, Quan-Liang Shang, Cong Ma, Xiangyu Chen, Enhua Xiao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b96d24f95c03486ba3cd13bc8e5e3246
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b96d24f95c03486ba3cd13bc8e5e3246
record_format	dspace
spelling	oai:doaj.org-article:b96d24f95c03486ba3cd13bc8e5e32462021-12-02T14:28:21ZCorrelation between early features and prognosis of symptomatic COVID-19 discharged patients in Hunan, China10.1038/s41598-021-83654-72045-2322https://doaj.org/article/b96d24f95c03486ba3cd13bc8e5e32462021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83654-7https://doaj.org/toc/2045-2322Abstract To determine the correlation between the clinical, laboratory, and radiological findings and the hospitalization days in Coronavirus Infectious Disease-19 (COVID-19) discharged patients. We retrospectively identified 172 discharged patients with COVID-19 pneumonia from January 10, 2020, to February 28, 2020, in Hunan province. The patients were categorized into group 1 (≤ 19 days) and group 2 (> 19 days) based on the time from symptom onset to discharge. Cough during admission occurred more commonly in group 2 (68.4%) than in group 1 (53.1%, p = 0.042). White blood cell (p = 0.045), neutrophil counts (p = 0.023), Alanine aminotransferase (p = 0.029), Aspartate aminotransferase (p = 0.027) and Lactate dehydrogenase (p = 0.021) that were above normal were more common in group 2. Patients with single lesions were observed more in group 1(17.7%, p = 0.018) and multiple lesions observed more in group 2(86.8%, p = 0.012). The number of lobes involved (p = 0.008) in the CT score (p = 0.001) for each patient was all differences between the two groups with a statistically significant difference. Mixed ground-glass opacity (GGO) and consolidation appearances were observed in most patients. GGO components > consolidation appearance was more common in group 1 (25.0%) than in group 2 (8.0%) with a significant difference (0.015), GGO < consolidation was more common in group 2(71.1%, p = 0.012). From the logistic regression analysis, the CT score (OR, 1.223; 95% CI, 1.004 to 1.491, p = 0.046) and the appearance of GGO > consolidation (OR, 0.150; 95% CI, 0.034 to 0.660, p = 0.012) were independently associated with the hospitalization days. Thus, special attention should be paid to the role of radiological features in monitoring the disease prognosis.Yeyu CaiJiayi LiuHaitao YangTaili ChenQizhi YuJuan ChenDeng HuangZhu ChenQuan-Liang ShangCong MaXiangyu ChenEnhua XiaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yeyu Cai Jiayi Liu Haitao Yang Taili Chen Qizhi Yu Juan Chen Deng Huang Zhu Chen Quan-Liang Shang Cong Ma Xiangyu Chen Enhua Xiao Correlation between early features and prognosis of symptomatic COVID-19 discharged patients in Hunan, China
description	Abstract To determine the correlation between the clinical, laboratory, and radiological findings and the hospitalization days in Coronavirus Infectious Disease-19 (COVID-19) discharged patients. We retrospectively identified 172 discharged patients with COVID-19 pneumonia from January 10, 2020, to February 28, 2020, in Hunan province. The patients were categorized into group 1 (≤ 19 days) and group 2 (> 19 days) based on the time from symptom onset to discharge. Cough during admission occurred more commonly in group 2 (68.4%) than in group 1 (53.1%, p = 0.042). White blood cell (p = 0.045), neutrophil counts (p = 0.023), Alanine aminotransferase (p = 0.029), Aspartate aminotransferase (p = 0.027) and Lactate dehydrogenase (p = 0.021) that were above normal were more common in group 2. Patients with single lesions were observed more in group 1(17.7%, p = 0.018) and multiple lesions observed more in group 2(86.8%, p = 0.012). The number of lobes involved (p = 0.008) in the CT score (p = 0.001) for each patient was all differences between the two groups with a statistically significant difference. Mixed ground-glass opacity (GGO) and consolidation appearances were observed in most patients. GGO components > consolidation appearance was more common in group 1 (25.0%) than in group 2 (8.0%) with a significant difference (0.015), GGO < consolidation was more common in group 2(71.1%, p = 0.012). From the logistic regression analysis, the CT score (OR, 1.223; 95% CI, 1.004 to 1.491, p = 0.046) and the appearance of GGO > consolidation (OR, 0.150; 95% CI, 0.034 to 0.660, p = 0.012) were independently associated with the hospitalization days. Thus, special attention should be paid to the role of radiological features in monitoring the disease prognosis.
format	article
author	Yeyu Cai Jiayi Liu Haitao Yang Taili Chen Qizhi Yu Juan Chen Deng Huang Zhu Chen Quan-Liang Shang Cong Ma Xiangyu Chen Enhua Xiao
author_facet	Yeyu Cai Jiayi Liu Haitao Yang Taili Chen Qizhi Yu Juan Chen Deng Huang Zhu Chen Quan-Liang Shang Cong Ma Xiangyu Chen Enhua Xiao
author_sort	Yeyu Cai
title	Correlation between early features and prognosis of symptomatic COVID-19 discharged patients in Hunan, China
title_short	Correlation between early features and prognosis of symptomatic COVID-19 discharged patients in Hunan, China
title_full	Correlation between early features and prognosis of symptomatic COVID-19 discharged patients in Hunan, China
title_fullStr	Correlation between early features and prognosis of symptomatic COVID-19 discharged patients in Hunan, China
title_full_unstemmed	Correlation between early features and prognosis of symptomatic COVID-19 discharged patients in Hunan, China
title_sort	correlation between early features and prognosis of symptomatic covid-19 discharged patients in hunan, china
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b96d24f95c03486ba3cd13bc8e5e3246
work_keys_str_mv	AT yeyucai correlationbetweenearlyfeaturesandprognosisofsymptomaticcovid19dischargedpatientsinhunanchina AT jiayiliu correlationbetweenearlyfeaturesandprognosisofsymptomaticcovid19dischargedpatientsinhunanchina AT haitaoyang correlationbetweenearlyfeaturesandprognosisofsymptomaticcovid19dischargedpatientsinhunanchina AT tailichen correlationbetweenearlyfeaturesandprognosisofsymptomaticcovid19dischargedpatientsinhunanchina AT qizhiyu correlationbetweenearlyfeaturesandprognosisofsymptomaticcovid19dischargedpatientsinhunanchina AT juanchen correlationbetweenearlyfeaturesandprognosisofsymptomaticcovid19dischargedpatientsinhunanchina AT denghuang correlationbetweenearlyfeaturesandprognosisofsymptomaticcovid19dischargedpatientsinhunanchina AT zhuchen correlationbetweenearlyfeaturesandprognosisofsymptomaticcovid19dischargedpatientsinhunanchina AT quanliangshang correlationbetweenearlyfeaturesandprognosisofsymptomaticcovid19dischargedpatientsinhunanchina AT congma correlationbetweenearlyfeaturesandprognosisofsymptomaticcovid19dischargedpatientsinhunanchina AT xiangyuchen correlationbetweenearlyfeaturesandprognosisofsymptomaticcovid19dischargedpatientsinhunanchina AT enhuaxiao correlationbetweenearlyfeaturesandprognosisofsymptomaticcovid19dischargedpatientsinhunanchina
_version_	1718391275575574528

Correlation between early features and prognosis of symptomatic COVID-19 discharged patients in Hunan, China

Ejemplares similares