Remineralization potential of nano-hydroxyapatite on enamel and cementum surrounding margin of computer-aided design and computer-aided manufacturing ceramic restoration

Niwut Juntavee,1 Apa Juntavee,2 Preeyarat Plongniras3 1Department of Prosthodontics, Faculty of Dentistry, Khon Kaen University, Khon Kaen, Thailand; 2Department of Pediatric Dentistry, Faculty of Dentistry, Khon Kaen University, Khon Kaen, Thailand; 3Division of Biomaterials and Prosthodontics Res...

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Autores principales:	Juntavee N, Juntavee A, Plongniras P
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	CAD-CAM margin nano-hydroxyapatite remineralization zirconia Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/b9705461273f48798486b3ed79302a17
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spelling	oai:doaj.org-article:b9705461273f48798486b3ed79302a172021-12-02T08:55:07ZRemineralization potential of nano-hydroxyapatite on enamel and cementum surrounding margin of computer-aided design and computer-aided manufacturing ceramic restoration1178-2013https://doaj.org/article/b9705461273f48798486b3ed79302a172018-05-01T00:00:00Zhttps://www.dovepress.com/remineralization-potential-of-nano-hydroxyapatite-on-enamel-and-cement-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Niwut Juntavee,1 Apa Juntavee,2 Preeyarat Plongniras3 1Department of Prosthodontics, Faculty of Dentistry, Khon Kaen University, Khon Kaen, Thailand; 2Department of Pediatric Dentistry, Faculty of Dentistry, Khon Kaen University, Khon Kaen, Thailand; 3Division of Biomaterials and Prosthodontics Research, Faculty of Dentistry, Khon Kaen University, Khon Kaen, Thailand Objective: This study investigates the effects of nano-hydroxyapatite (NHA) gel and Clinpro (CP) on remineralization potential of enamel and cementum at the cavosurface area of computer-aided design and computer-aided manufacturing ceramic restoration. Materials and methods: Thirty extracted human mandibular third molars were sectioned at 1 mm above and below the cemento–enamel junction to remove the cemento–enamel junction portions and replaced them with zirconia ceramic disks by bonding them to the crown and root portions with resin cement. The enamel and cementum with an area of 4×4 mm2 surrounding the ceramic disk was demineralized with carbopol. The demineralized surfaces were treated with either NHA or CP, while 1 group was left with no treatment. Vickers microhardness of enamel and cementum were determined before demineralization, after demineralization, and after remineralization. Analysis of variance and Tukey multiple comparisons were used to determine statistically significant differences at 95% level of confidence. Scanning electron microscopy and X-ray diffraction were used to evaluate for surface alterations. Results: The mean ± SD of Vickers microhardness for before demineralization, after demineralization, and after remineralization for enamel and cementum were 377.37±22.99, 161.95±10.54, 161.70±5.92 and 60.37±3.81, 17.65±0.91, 17.04±1.00 for the no treatment group; 378.20±18.76, 160.72±8.38, 200.08±8.29 and 62.58±3.37, 18.38±1.33, 27.99±2.68 for the NHA groups; and 380.53±25.14, 161.94±5.66, 193.16±7.54 and 62.78±4.75, 19.07±1.30, 24.46±2.02 for the CP groups. Analysis of variance indicated significant increase in microhardness of demineralized enamel and cementum upon the application of either NHA or CP (p<0.05). Post hoc multiple comparisons indicated significantly higher remineralization capability of NHA for both enamel and cementum than CP (p<0.05), as evidenced by scanning electron microscopy, indicating NHA particle deposition in the area of remineralization, and crystallinity accumulation, as indicated by X-ray diffraction. Conclusion: NHA gel and CP were capable of remineralization of the enamel and cementum. NHA was more capable in the remineralization process than CP. NHA was extremely capable in the remineralization process for enamel and cementum surrounding the margin of the computer-aided design and computer-aided manufacturing ceramic. Keywords: biomimetics, CAD-CAM, cavosurface margin, root caries, zirconiaJuntavee NJuntavee APlongniras PDove Medical PressarticleCAD-CAMmarginnano-hydroxyapatiteremineralizationzirconiaMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 2755-2765 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	CAD-CAM margin nano-hydroxyapatite remineralization zirconia Medicine (General) R5-920
spellingShingle	CAD-CAM margin nano-hydroxyapatite remineralization zirconia Medicine (General) R5-920 Juntavee N Juntavee A Plongniras P Remineralization potential of nano-hydroxyapatite on enamel and cementum surrounding margin of computer-aided design and computer-aided manufacturing ceramic restoration
description	Niwut Juntavee,1 Apa Juntavee,2 Preeyarat Plongniras3 1Department of Prosthodontics, Faculty of Dentistry, Khon Kaen University, Khon Kaen, Thailand; 2Department of Pediatric Dentistry, Faculty of Dentistry, Khon Kaen University, Khon Kaen, Thailand; 3Division of Biomaterials and Prosthodontics Research, Faculty of Dentistry, Khon Kaen University, Khon Kaen, Thailand Objective: This study investigates the effects of nano-hydroxyapatite (NHA) gel and Clinpro (CP) on remineralization potential of enamel and cementum at the cavosurface area of computer-aided design and computer-aided manufacturing ceramic restoration. Materials and methods: Thirty extracted human mandibular third molars were sectioned at 1 mm above and below the cemento–enamel junction to remove the cemento–enamel junction portions and replaced them with zirconia ceramic disks by bonding them to the crown and root portions with resin cement. The enamel and cementum with an area of 4×4 mm2 surrounding the ceramic disk was demineralized with carbopol. The demineralized surfaces were treated with either NHA or CP, while 1 group was left with no treatment. Vickers microhardness of enamel and cementum were determined before demineralization, after demineralization, and after remineralization. Analysis of variance and Tukey multiple comparisons were used to determine statistically significant differences at 95% level of confidence. Scanning electron microscopy and X-ray diffraction were used to evaluate for surface alterations. Results: The mean ± SD of Vickers microhardness for before demineralization, after demineralization, and after remineralization for enamel and cementum were 377.37±22.99, 161.95±10.54, 161.70±5.92 and 60.37±3.81, 17.65±0.91, 17.04±1.00 for the no treatment group; 378.20±18.76, 160.72±8.38, 200.08±8.29 and 62.58±3.37, 18.38±1.33, 27.99±2.68 for the NHA groups; and 380.53±25.14, 161.94±5.66, 193.16±7.54 and 62.78±4.75, 19.07±1.30, 24.46±2.02 for the CP groups. Analysis of variance indicated significant increase in microhardness of demineralized enamel and cementum upon the application of either NHA or CP (p<0.05). Post hoc multiple comparisons indicated significantly higher remineralization capability of NHA for both enamel and cementum than CP (p<0.05), as evidenced by scanning electron microscopy, indicating NHA particle deposition in the area of remineralization, and crystallinity accumulation, as indicated by X-ray diffraction. Conclusion: NHA gel and CP were capable of remineralization of the enamel and cementum. NHA was more capable in the remineralization process than CP. NHA was extremely capable in the remineralization process for enamel and cementum surrounding the margin of the computer-aided design and computer-aided manufacturing ceramic. Keywords: biomimetics, CAD-CAM, cavosurface margin, root caries, zirconia
format	article
author	Juntavee N Juntavee A Plongniras P
author_facet	Juntavee N Juntavee A Plongniras P
author_sort	Juntavee N
title	Remineralization potential of nano-hydroxyapatite on enamel and cementum surrounding margin of computer-aided design and computer-aided manufacturing ceramic restoration
title_short	Remineralization potential of nano-hydroxyapatite on enamel and cementum surrounding margin of computer-aided design and computer-aided manufacturing ceramic restoration
title_full	Remineralization potential of nano-hydroxyapatite on enamel and cementum surrounding margin of computer-aided design and computer-aided manufacturing ceramic restoration
title_fullStr	Remineralization potential of nano-hydroxyapatite on enamel and cementum surrounding margin of computer-aided design and computer-aided manufacturing ceramic restoration
title_full_unstemmed	Remineralization potential of nano-hydroxyapatite on enamel and cementum surrounding margin of computer-aided design and computer-aided manufacturing ceramic restoration
title_sort	remineralization potential of nano-hydroxyapatite on enamel and cementum surrounding margin of computer-aided design and computer-aided manufacturing ceramic restoration
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/b9705461273f48798486b3ed79302a17
work_keys_str_mv	AT juntaveen remineralizationpotentialofnanohydroxyapatiteonenamelandcementumsurroundingmarginofcomputeraideddesignandcomputeraidedmanufacturingceramicrestoration AT juntaveea remineralizationpotentialofnanohydroxyapatiteonenamelandcementumsurroundingmarginofcomputeraideddesignandcomputeraidedmanufacturingceramicrestoration AT plongnirasp remineralizationpotentialofnanohydroxyapatiteonenamelandcementumsurroundingmarginofcomputeraideddesignandcomputeraidedmanufacturingceramicrestoration
_version_	1718398327097131008

Remineralization potential of nano-hydroxyapatite on enamel and cementum surrounding margin of computer-aided design and computer-aided manufacturing ceramic restoration

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