Comprehensive reference ranges for hematology and clinical chemistry laboratory parameters derived from normal Nigerian adults.

<h4>Background</h4>Interpretation of laboratory test results with appropriate diagnostic accuracy requires reference or cutoff values. This study is a comprehensive determination of reference values for hematology and clinical chemistry in apparently healthy voluntary non-remunerated blo...

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Autores principales:	Timzing Miri-Dashe, Sophia Osawe, Monday Tokdung, Nenbammun Daniel, Rahila Pam Choji, Ille Mamman, Kurt Deme, Dapus Damulak, Alash'le Abimiku
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b973a7bec75a458a8d2676b8990401f6
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spelling	oai:doaj.org-article:b973a7bec75a458a8d2676b8990401f62021-11-18T08:19:02ZComprehensive reference ranges for hematology and clinical chemistry laboratory parameters derived from normal Nigerian adults.1932-620310.1371/journal.pone.0093919https://doaj.org/article/b973a7bec75a458a8d2676b8990401f62014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24832127/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Interpretation of laboratory test results with appropriate diagnostic accuracy requires reference or cutoff values. This study is a comprehensive determination of reference values for hematology and clinical chemistry in apparently healthy voluntary non-remunerated blood donors and pregnant women.<h4>Methods and findings</h4>Consented clients were clinically screened and counseled before testing for HIV, Hepatitis B, Hepatitis C and Syphilis. Standard national blood donors' questionnaire was administered to consented blood donors. Blood from qualified volunteers was used for measurement of complete hematology and chemistry parameters. Blood samples were analyzed from a total of 383 participants, 124 (32.4%) males, 125 (32.6%) non-pregnant females and 134 pregnant females (35.2%) with a mean age of 31 years. Our results showed that the red blood cells count (RBC), Hemoglobin (HB) and Hematocrit (HCT) had significant gender difference (p = 0.000) but not for total white blood count (p>0.05) which was only significantly higher in pregnant verses non-pregnant women (p = 0.000). Hemoglobin and Hematocrit values were lower in pregnancy (P = 0.000). Platelets were significantly higher in females than men (p = 0.001) but lower in pregnant women (p = .001) with marked difference in gestational period. For clinical chemistry parameters, there was no significant difference for sodium, potassium and chloride (p>0.05) but gender difference exists for Bicarbonate (HCO3), Urea nitrogen, Creatinine as well as the lipids (p<0.05). Total bilirubin was significantly higher in males than females (p = 0.000). Significant differences exist for all chemistry parameters between pregnant and non-pregnant women in this study (p<0.05), except Amylase and total cholesterol (p>0.05).<h4>Conclusions</h4>Hematological and Clinical Chemistry reference ranges established in this study showed significant gender differences. Pregnant women also differed from non-pregnant females and during pregnancy. This is the first of such comprehensive study to establish reference values among adult Nigerians and difference observed underscore the need to establish reference values for different populations.Timzing Miri-DasheSophia OsaweMonday TokdungNenbammun DanielRahila Pam ChojiIlle MammanKurt DemeDapus DamulakAlash'le AbimikuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 5, p e93919 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Timzing Miri-Dashe Sophia Osawe Monday Tokdung Nenbammun Daniel Rahila Pam Choji Ille Mamman Kurt Deme Dapus Damulak Alash'le Abimiku Comprehensive reference ranges for hematology and clinical chemistry laboratory parameters derived from normal Nigerian adults.
description	<h4>Background</h4>Interpretation of laboratory test results with appropriate diagnostic accuracy requires reference or cutoff values. This study is a comprehensive determination of reference values for hematology and clinical chemistry in apparently healthy voluntary non-remunerated blood donors and pregnant women.<h4>Methods and findings</h4>Consented clients were clinically screened and counseled before testing for HIV, Hepatitis B, Hepatitis C and Syphilis. Standard national blood donors' questionnaire was administered to consented blood donors. Blood from qualified volunteers was used for measurement of complete hematology and chemistry parameters. Blood samples were analyzed from a total of 383 participants, 124 (32.4%) males, 125 (32.6%) non-pregnant females and 134 pregnant females (35.2%) with a mean age of 31 years. Our results showed that the red blood cells count (RBC), Hemoglobin (HB) and Hematocrit (HCT) had significant gender difference (p = 0.000) but not for total white blood count (p>0.05) which was only significantly higher in pregnant verses non-pregnant women (p = 0.000). Hemoglobin and Hematocrit values were lower in pregnancy (P = 0.000). Platelets were significantly higher in females than men (p = 0.001) but lower in pregnant women (p = .001) with marked difference in gestational period. For clinical chemistry parameters, there was no significant difference for sodium, potassium and chloride (p>0.05) but gender difference exists for Bicarbonate (HCO3), Urea nitrogen, Creatinine as well as the lipids (p<0.05). Total bilirubin was significantly higher in males than females (p = 0.000). Significant differences exist for all chemistry parameters between pregnant and non-pregnant women in this study (p<0.05), except Amylase and total cholesterol (p>0.05).<h4>Conclusions</h4>Hematological and Clinical Chemistry reference ranges established in this study showed significant gender differences. Pregnant women also differed from non-pregnant females and during pregnancy. This is the first of such comprehensive study to establish reference values among adult Nigerians and difference observed underscore the need to establish reference values for different populations.
format	article
author	Timzing Miri-Dashe Sophia Osawe Monday Tokdung Nenbammun Daniel Rahila Pam Choji Ille Mamman Kurt Deme Dapus Damulak Alash'le Abimiku
author_facet	Timzing Miri-Dashe Sophia Osawe Monday Tokdung Nenbammun Daniel Rahila Pam Choji Ille Mamman Kurt Deme Dapus Damulak Alash'le Abimiku
author_sort	Timzing Miri-Dashe
title	Comprehensive reference ranges for hematology and clinical chemistry laboratory parameters derived from normal Nigerian adults.
title_short	Comprehensive reference ranges for hematology and clinical chemistry laboratory parameters derived from normal Nigerian adults.
title_full	Comprehensive reference ranges for hematology and clinical chemistry laboratory parameters derived from normal Nigerian adults.
title_fullStr	Comprehensive reference ranges for hematology and clinical chemistry laboratory parameters derived from normal Nigerian adults.
title_full_unstemmed	Comprehensive reference ranges for hematology and clinical chemistry laboratory parameters derived from normal Nigerian adults.
title_sort	comprehensive reference ranges for hematology and clinical chemistry laboratory parameters derived from normal nigerian adults.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/b973a7bec75a458a8d2676b8990401f6
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Comprehensive reference ranges for hematology and clinical chemistry laboratory parameters derived from normal Nigerian adults.

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